MCHR1 Antibody
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中文名稱：MCHR1兔多克隆抗體
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貨號：CSB-PA132314
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA132314(MCHR1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA132314(MCHR1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) -
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-6: Human fetal liver tissue, Human testis tissue, 293T cells, A172 cells, mouse brain tissue, human fetal brain tissue, Primary antibody: CSB-PA132314(MCHR1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：MCHR1; GPR24; SLC1; Melanin-concentrating hormone receptor 1; MCH receptor 1; MCH-R1; MCHR-1; G-protein coupled receptor 24; MCH-1R; MCH1R; MCHR; SLC-1; Somatostatin receptor-like protein
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthetic peptide of Human MCHR1
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
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基因功能參考文獻：
- Polymorphisms in the MCHR1 gene are associated with differences in body composition and interact with physiologic and energy-related lifestyle factors. PMID: 24305679
- results suggest that MCHR1 may influence schizophrenia susceptibility, in particular among men and patients responding to conventional (nonclozapine) treatment PMID: 22081064
- SLC-1 protein human mutation demonstrated important genetic susceptibility of sporadic nonsyndromic hearing loss in China. PMID: 22154049
- DNA methylation at MCHR1 is allele-specific, age-dependent, body mass index-associated and affects transcription. PMID: 21637341
- two loss-of-function mutants were identified in markedly underweight individuals, raising the possibility that a lean phenotype may be linked to deficient MCHR1 signaling PMID: 20833795
- MCHR1 expression level was 1.6 times higher in vitiligo uninvolved skin (P < 0.05) and 2.23 times lower in involved skin (P < 0.05), when compared to healthy control skin. PMID: 20888736
- data suggest that RGS2 and RGS8 differentially associate with MCHR1 and may represent two distinct modes of signaling mechanisms in vivo PMID: 20633139
- Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. PMID: 11839762
- MCH1 and MCH2 receptors were investigated and are different from those in SVK14 cells. PMID: 12127971
- MCHR1 is expressed and functional in human skin PMID: 12176038
- MCHR1 receptor expression on most cell types can trigger, in the presence of MCH, cAMP synthesis and calcium mobilization in peripheral blood mononuclear cells (PBMCs). Moreover, MCH treatment decreases the CD3-stimulated PBMC proliferation in vitro. PMID: 12220661
- study demonstrates a complex interaction between melanin concentrating hormone receptor 1 and Gs protein-coupled signaling pathways PMID: 12865333
- multiple antibody binding sites on melanin-concentrating hormone receptor 1 in vitiligo, including regions between amino acids 1 to 138 and 139 to 298. PMID: 14632194
- Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail PMID: 15590649
- a single point mutation at position 255 (T255A), which is located at the junction of intracellular loop 3 and transmembrane domain 6, reduces the MCHR1 cell surface expression level to 20% of that observed for the wild-type receptor PMID: 15928315
- Association of MCHR1 alleles/haplotype detected might be related to juvenile-onset obesity, conditional on a particular genetic and/or environmental background. PMID: 15941924
- Our results suggest that MIZIP might play an important role in mammalian cells by associating with tubulin and thus might provide a link between MCHR1 and tubulin functions. PMID: 16039987
- study suggests that severe forms of obesity with early onset may be associated with single nucleotide polymorphisms in melanin-concentrating hormone receptor 1 (MCHR1) PMID: 16186414
- Study suggest that GPR24 variants may confer susceptibility to both bipolar affective disorder and schizophrenia. PMID: 16741940
- Single nucleotide polymorphisms of MCHR1 did not have effects on metabolic variables in humans. PMID: 18198296
- These data suggest that a functional interaction between MCHR1 and caveolin-1 in lipid rafts exists and provide a basis for further biochemical studies to understand the significance on MCH-mediated signal transduction events. PMID: 18722347
- analysis of epitope specificity of MCHR1 antibodies PMID: 19320743
- The 10-amino-acid cyclic core of the hMCH neuropeptide with the Arg attached to the N-terminus of the disulfide ring is sufficient for full activation of melanin-concentrating hormone receptor 1. PMID: 11478907
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：G-protein coupled receptor 1 family
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組織特異性：Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.
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數據庫鏈接：
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