MAT1A Antibody
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中文名稱：MAT1A兔多克隆抗體
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貨號：CSB-PA561453
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規格：￥1100
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圖片：
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Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: CSB-PA561453(MAT1A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
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其他：
產品詳情
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Uniprot No.：
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基因名：MAT1A
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別名：MAT1A antibody; AMS1 antibody; MATA1S-adenosylmethionine synthase isoform type-1 antibody; AdoMet synthase 1 antibody; EC 2.5.1.6 antibody; Methionine adenosyltransferase 1 antibody; MAT 1 antibody; Methionine adenosyltransferase I/III antibody; MAT-I/III antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Fusion protein of Human MAT1A
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
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基因功能參考文獻：
- Increased MAT1A expression is associated with recurrence in hepatocellular carcinoma. PMID: 29448301
- Of the 22 single nucleotide polymorphisms studied, the rs8193 polymorphism lying in the micro-RNA binding site of 3'-UTR of CD44 was significantly (P=.0270) associated with RT-induced adverse skin reactions. Generalized multifactor dimensionality reduction analysis showed significant (P=.0107) gene-gene interactions between MAT1A and CD44. PMID: 27816361
- A compound mutation of the methionine adenosyltransferase 1A (MAT1A) gene, c.345delA and c.529C>T, was identified in the patient, and His father and mother were found to be heterozygous for the c.345delA mutation and c.529C>T mutation, respectively. PMID: 28186605
- S-adenosyl-L-methionine diminishes hepatitis C virus expression by altering MAT1A/2A signaling in hepatocytes. PMID: 27076759
- 5-Aza-CdR showed no effects on MAT2A methylation. PMID: 24377546
- The mutations in the other 10 patients showed autosomal recessive inheritance and included eight novel MAT1A mutations. PMID: 24231718
- Liver-specific isoenzyme MAT1A is genetically linked with an inborn metabolic disorder of hypermethioninemia, as well as a ubiquitously expressed isoenzyme MAT2A, whose enzymatic activity is regulated by an associated subunit MAT2B. PMID: 23425511
- Methionine adenosyltransferase I/III deficiency is caused by mutations in the MAT1A gene. (Review) PMID: 22951388
- upregulation of miR-664, miR-485-3p, and miR-495 contributes to lower MAT1A expression in HCC, and enhanced tumorigenesis may provide potential targets for HCC therapy. PMID: 23241961
- Report SNPs that are highly associated with hepatic GNMT protein expression and the coordinate regulation of MAT1A levels. PMID: 22807109
- we found for the first time a post-transcriptional regulation of MAT1A and MAT2A by AUF1 and HuR in hepatocellular carcinoma. PMID: 22318685
- Human Dead-box protein 3 (DDX3X), a RNA helicase regulating RNA splicing, export, transcription and translation was down-regulated upon MAT1A expression. PMID: 22270009
- genetic variant MAT1A 3U1510 displayed a significant interaction with dietary n-3:n-6 polyunsaturated fatty acids ratio in determining plasma homocysteine PMID: 21185701
- Coexpression of MAT2A and MAT2B in COS-1 cells resulted in significantly increased MAT enzyme activity. PMID: 21813468
- Methylation of the MAT1A coding region can inhibit gene transcription. This represents a key mechanism for decreased MAT1A expression in hepatocellular carcinoma. PMID: 21678410
- Results show a rather high frequency of hypermethioninaemia due to MAT I/III deficiency (MAT1A dominant mutation) in the Galician neonatal population. PMID: 18500573
- MAT and tripolyphosphatase (PPPase) activities of 18 MAT1A variants, six of them novel, and none of them previously assayed for activity. With the exception of G69S and Y92H, all recombinant proteins showed impairment (usually severe) of MAT activity. PMID: 20675163
- expression of the MAT1A gene is mediated by C/EBP and is indirectly upregulated by T(3) in hepatoma cell lines PMID: 20146079
- MAT1A variants were strongly associated with hypertension and stroke; improving folate and vitamin B-6 status may decrease cardiovascular disease risk of only a subset of the population, depending on genotype. PMID: 20335551
- Mutations in the MAT1A gene are the most prevalent cause of isolated hypermethioninemia in Taiwanese. PMID: 15935930
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相關疾病：Methionine adenosyltransferase deficiency (MATD)
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蛋白家族：AdoMet synthase family
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組織特異性：Expressed in liver.
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