MARK3 Antibody, HRP conjugated

說明書

中文名稱：

MARK3兔多克隆抗體, HRP偶聯
貨號：

CSB-PA013498LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MARK3 Polyclonal antibody
Uniprot No.：

P27448
基因名：

MARK3
別名：

C-TAK1 antibody; Cdc25C associated protein kinase 1 antibody; Cdc25C-associated protein kinase 1 antibody; cTAK1 antibody; ELKL motif kinase 2 antibody; EMK-2 antibody; Emk2 antibody; ETK 1 antibody; KIAA4230 antibody; KP78 antibody; MAP microtubule affinity regulating kinase 3 antibody; MAP/microtubule affinity-regulating kinase 3 antibody; Mark3 antibody; MARK3_HUMAN antibody; Par 1a antibody; PAR1A antibody; Protein kinase STK10 antibody; Ser/Thr protein kinase PAR-1 antibody; Serine threonine protein kinase p78 antibody; Serine/threonine-protein kinase p78 antibody; SerThr protein kinase PAR 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human MAP/microtubule affinity-regulating kinase 3 protein (368-667AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1.
基因功能參考文獻：
1. Authors identified a regulatory switch controlled by MARK3 that couples microtubules to the actin cytoskeleton to establish epithelial cell polarity through ARHGEF2. PMID: 29089450
2. findings indicate that brain PP-1I associates with and is regulated by the associated protein kinases C-TAK1 and PFTK1 PMID: 25028520
3. We have shown that serum ALP levels modified the association of MARK3 with bone mineral density in osetoporosis for Chinese patients. PMID: 23894155
4. interaction between Mitf and C-TAK1 was demonstrated. PMID: 20214879
5. results show that LKB1 can direct the phosphorylation of the serine-threonine kinase PAR1A PMID: 12879020
6. identify sequence motifs required for stable C-TAK1 association and substrate phosphorylation PMID: 12941695
7. The C-TAK1/p78 constitutively associates with and phosphorylates KSR1 generating a 14-3-3 binding site. PMID: 15182702
8. Data show that the protein kinase Cdc25 C-associated kinase 1 (C-TAK1) is a binding partner and a substrate of Pim-1, and suggest a role for Pim-1 as a positive regulator at the G(2)/M transition of the cell cycle. PMID: 15319445
9. 14-3-3 binding to MARK3 is dependent on phosphorylation. PMID: 16968750
10. Class IIa histone deacetylases (HDACs) are subjected to signal-independent nuclear export that relies on their constitutive phosphorylation. EMK and C-TAK1, are identified as regulators of this process. PMID: 16980613
11. identify a molecular mechanism through which the hMARK3 UBA domain has evolved to bind the kinase domain PMID: 17726107
12. occurrence of an unusual TG 3' splice site in intron 3 PMID: 17672918
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亞細胞定位：

Cell membrane; Peripheral membrane protein. Cell projection, dendrite. Cytoplasm.
蛋白家族：

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 6897

OMIM: 602678

KEGG: hsa:4140

STRING: 9606.ENSP00000411397

UniGene: Hs.35828

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