MAP4K2 Antibody, FITC conjugated
產(chǎn)品詳情
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產(chǎn)品名稱：
Rabbit anti-Homo sapiens (Human) MAP4K2 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：
B lymphocyte serine/threonine protein kinase antibody; B lymphocyte serine/threonine-protein kinase antibody; BL44 antibody; GC kinase antibody; GCK antibody; Germinal center kinase antibody; germinal centre kinase (GC kinase) antibody; M4K2_HUMAN antibody; Map4k2 antibody; MAPK/ERK kinase kinase kinase 2 antibody; MEK kinase kinase 2 antibody; MEKKK 2 antibody; Mitogen activated protein kinase kinase kinase kinase 2 antibody; Mitogen-activated protein kinase kinase kinase kinase 2 antibody; Rab8 interacting protein antibody; Rab8 interacting protein, formerly antibody; Rab8-interacting protein antibody; RAB8IP antibody; RAB8IP, formerly antibody
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宿主：
Rabbit
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反應(yīng)種屬：
Human
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免疫原：
Recombinant Human Mitogen-activated protein kinase kinase kinase kinase 2 protein (386-469AA)
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免疫原種屬：
Homo sapiens (Human)
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標(biāo)記方式：
FITC
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克隆類型：
Polyclonal
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抗體亞型：
IgG
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純化方式：
>95%, Protein G purified
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濃度：
It differs from different batches. Please contact us to confirm it.
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保存緩沖液：
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
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產(chǎn)品提供形式：
Liquid
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儲(chǔ)存條件：
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
靶點(diǎn)詳情
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功能：
Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.
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基因功能參考文獻(xiàn)：
- These studies demonstrate, for the first time, that GCK is a molecular therapeutic target in DLBCL tumors and that inhibiting GCK may significantly extend DLBCL patient survival. PMID: 27151888
- Data indicate 4-substituted 1H-pyrrolo[2,3-b]pyridines as potent inhibitors against TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). PMID: 25075558
- Data suggest that the Rabin8-Rab8-Sec15 interaction may couple the activation of Rab8 to the recruitment of the Rab8 effector and is involved in the regulation of vesicular trafficking for primary cilium formation. PMID: 22433857
- CCM3 is located on the Golgi apparatus, forming a complex with proteins of the germinal center kinase III (GCKIII) family and GM130, a Golgi-resident protein. PMID: 20332113
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亞細(xì)胞定位：
Cytoplasm. Basolateral cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
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蛋白家族：
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
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組織特異性：
Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined.
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數(shù)據(jù)庫(kù)鏈接：
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