MAL Antibody, Biotin conjugated
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中文名稱：MAL兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA013372LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MAL Polyclonal antibody
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Uniprot No.：
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基因名：MAL
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別名：MAL; Myelin and lymphocyte protein; T-lymphocyte maturation-associated protein
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Myelin and lymphocyte protein (1-84AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.
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基因功能參考文獻：
- In high-grade serous ovarian carcinoma patients, MAL was overexpressed in platinum-resistant compared to platinum-sensitive patients and resulted as an independent prognostic marker of survival. PMID: 28545541
- MAL and TMEM220 were specifically methylated and were down-regulated in human gastric cancer. PMID: 27329150
- This study revealed that Merkel cell polyomavirus -negative Merkel cell carcinomas significantly expressed higher CADM1 and lower MAL than Merkel cell polyomavirus -positive Merkel cell carcinomas PMID: 26772392
- CADM1/MAL methylation increases with severity of cervical intraepithelial neoplasia PMID: 26219541
- Hypermethylation of the selected markers (MAL, PRIMA1, PTGDR and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer. PMID: 26482433
- Data suggest that expression of MAL in cells confers both ETX (Clostridium perfringens epsilon-toxin) binding and susceptibility to ETX-mediated cell death; cells expressing rat MAL are 100 times more sensitive to ETX than cells expressing human MAL. PMID: 25993478
- The use of CADM1, MAL, and MIR124-2 as biomarkers for full molecular screening in HIV infected women who are also positive for human papillomavirus. PMID: 26473640
- MAL is a critical element of the machinery for exosome secretion and may constitute a target for modulating exosome secretion by human T cells. PMID: 26109641
- MAL hypermethylation is associated with esophageal carcinoma progression. PMID: 24088706
- Cytology and bi-marker CADM1/MAL-methylation analysis perform complementary for CIN2+/CIN3+ detection when used as triage tool on cervical scrapes of HPV positive women. PMID: 25667975
- DNA methylation analysis of CADM1, MAL and miR124-2 in cervical scrapes consistently detects cervical cancer PMID: 25281766
- The MAL gene repression related with lymph node metastasis and poor prognosis in gastric cancer, suggesting that the MAL may be a new candidate node metastasis-suppressor gene for gastric cancer. PMID: 24511665
- CADM1 and MAL methylation levels increased proportional to severity of the underlying lesion PMID: 23456988
- hypomethylation of LINE-1 and hypermethylation of SLIT2, MAL and IGFBP7 were frequently detected in NSCLCs and associated with various clinical features. PMID: 23381221
- MAL protein plays an important role during oral carcinogenesis, MAL gene expression was significantly decreased in oral squamous cell carcinoma compared with normal epithelium. PMID: 23224601
- Data indicate that DNA methylation status of multiple genes CADM1, MAL and hsa-miR-124-2 was analyzed in human papillomavirus (hrHPV)-positive cervical scrape. PMID: 23176198
- the methylation marker panel CADM1-M18 and MAL-M1 may serve as an alternative molecular triage tool for hrHPV-positive women. PMID: 21190187
- Data show that a combination of CADM1 and MAL methylation could represent a promising candidate triage tool for hrHPV-positive women. PMID: 21389098
- MAL is normally expressed in laryngeal epithelial cells and its expression changes at early stages of carcinoma development. PMID: 19670627
- This study supports roles for tyrosines 86 and 106 in signaling pathways involving MAL. PMID: 20822478
- Data suggest that the epigenetic inactivation of MAL, as a candidate tumor suppressor gene, can contribute to human epithelial cell carcinoma and may be served as a biomarker in HNSCC. PMID: 21092172
- The caspase-1 cleavage site in Mal is part of a TIR-domain interaction site. PMID: 20048342
- Data show that MAL transcript levels were higher in the resistant ovarian cell lines. PMID: 19642140
- The mal gene which is switched-off in all esophageal squamous cell carcinoma samples can be considered as a tumor suppressor gene PMID: 15188492
- Caveolin-1 and MAL are located on prostasomes secreted by prostate cancer cells PMID: 15466889
- Quantitative analysis carried out using pixel intensity variance demonstrated that the MAL protein is capable of modifying the plasma membrane, thereby increasing its resistance to detergent-induced pore formation. PMID: 16785208
- Loss of MAL expression is aasociated with precancerous lesions of the esophagus PMID: 17151798
- Promoter hypermethylation of MAL, shown to be present in colorectal adenomas and carcinomas and only rarely in normal mucosa. PMID: 17408629
- promoter hypermethylation of MAL was present in the vast majority of benign and malignant colorectal tumors, and only rarely in normal mucosa PMID: 18346269
- MAL has a putative tumour-suppressor gene function in gastric cancer, and detection of promoter hypermethylation may be useful as a prognostic marker. PMID: 19002170
- Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. PMID: 19208741
- suggesting the MAL gene as a new metastasis-suppressor candidate for head and neck cancer PMID: 19445022
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亞細胞定位：Membrane; Multi-pass membrane protein.
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蛋白家族：MAL family
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數據庫鏈接：
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