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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule.
基因功能參考文獻:
Increased expression of MAGE-D2 mRNA was associated with distant metastasis in Gastric Cancer. PMID: 25743330
MAGE-D2 is a dynamic protein whose shuttling properties could suggest a role in cell cycle regulation. PMID: 26705694
We found that MAGED2 mutations caused X-linked polyhydramnios with prematurity and a severe but transient form of antenatal Bartter's syndrome. PMID: 27120771
these results identify the expression of MAGE-D2 suppresses TRAIL receptor 2 and protects againstas TRAIL-induced apoptosis PMID: 22791814
Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues PMID: 11856887
Maged2 is mainly expressed in tissues of mesodermal origin PMID: 15162511
Results identified a cDNA clone, corresponding to MAGE D2 mRNA, from primary human bronchial epithelial cells which exhibits increased expression in vitro after treatment with all-trans retinoic acid. PMID: 15465002
MAGED2, a novel protein, is a p53-dissociator. PMID: 17912449
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相關疾病:
Bartter syndrome 5, antenatal, transient (BARTS5)
組織特異性:
Widely expressed. In the developing and adult kidney, expressed in the thick ascending limb of the loop of Henle and the distal convoluted tubules outside the loop.