MAF Antibody
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中文名稱：MAF兔多克隆抗體
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貨號：CSB-PA796747
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規格：￥2024
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圖片：
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Western blot analysis of extracts from HuvEc cells, HepG2 cells, HeLa cells and COLO205 cells, using Maf antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MAF Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from Internal of Human Maf.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.
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基因功能參考文獻：
- common variant , rs889472, of c-MAF is associated with gout susceptibility. PMID: 29080939
- we identified two heterozygous rare variants in genes that are involved in early cataract development; the novel c.809C>A; p.(Ser270Tyr) in MAF and the c.168C>G; p.(Tyr56 *) variant in CRYGD, previously reported as pathogenic PMID: 28849415
- UBE2O mediates c-Maf polyubiquitination and degradation, induces MM cell apoptosis, and suppresses myeloma tumor growth, which provides a novel insight in understanding myelomagenesis and UBE2O biology. PMID: 28673317
- The interaction between c-Maf and RORgammat, and Blimp-1. PMID: 28300844
- Polymorphisms rs9939609 (FTO gene) and rs1424233 (MAF gene) were genotyped using allelic discrimination assays in a prospective multicenter cohort study; these polymorphisms did not show associations with birth weight, BMI and Ponderal Index at discharge, and weight gain, neither testing for a dominant, additive nor for a recessive model. PMID: 23840443
- this study shows that genes associated with MAF-binding enhancers are suppressed in macrophages isolated from rheumatoid-arthritis patients, revealing a disease-associated signature of IFN-gamma-mediated repression PMID: 28813657
- Our results argued that increased expression of sIL6R from myeloid cells and subsequent c-Maf induction were adverse events for counteracting tumor-specific Th1 generation. Overall, this work provides a mechanistic rationale for sIL6R targeting to improve the efficacy of T-cell-mediated cancer immunotherapy PMID: 28235765
- These results define the role of MAF and GSK3 in the resistance of t(14;16) multiple myeloma to proteasome inhibitors. PMID: 27793878
- interplay between MATalpha1, c-Myc, and Maf proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis PMID: 26969892
- Epidermal differentiation gene regulatory networks are controlled by MAF and MAFB. PMID: 27097296
- Findings implicate the strong effects of ROS on multiple stem cell functions with a central role for c-Maf in stem cell senescence. PMID: 26496036
- Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf. PMID: 26719333
- Results suggest that MAF is a mediator of breast cancer bone metastasis. 16q23 gain or MAF protein overexpression in tumors may help to select patients at risk of bone relapse. PMID: 26376684
- Differential effect of cataract-associated mutations in MAF on transactivation of MAF target crystalline genes. PMID: 25064449
- Study added a novel insight for c-MAF ubiquitination and degradation, suggesting that c-MAF stability is strictly regulated. PMID: 25448412
- Disease-causing mutations were demonstrated to impair proper MAF phosphorylation, ubiquitination and proteasomal degradation, perturbed gene expression in primary skin fibroblasts, and induced neurodevelopmental defects in an in vivo model. PMID: 25865493
- MAF has a role in mediating crosstalk between Ras-MAPK and mTOR signaling in NF1 PMID: 24509877
- LPS promotes PDCD4 degradation via a pathway involving PI3K and mTOR, releasing Twist2, which induces IL-10 via c-Maf. PMID: 24982420
- Results imply a regulatory role for TMEM18, BDNF, MTCH2 and NEGR1 in adipocyte differentiation and biology. In addition, we show a variation of MAF expression during adipogenesis, while NPC1, PTER and SH2B1 were not regulated. PMID: 23229156
- c-Maf increases human immunodeficiency virus (HIV)-1 expression in interleukin (IL)-4-producing CD4 T cells by binding the proximal HIV-1 long terminal repeat region (LTR) and augmenting HIV-1 transcription. PMID: 22875803
- Bcl6 and Maf collaborate to orchestrate a suite of genes that define core characteristics of human Tfh cell biology. PMID: 22427637
- findings show that the transcription factor c-Maf/c-MAF is crucial for mechanosensory function; sensitivity to high-frequency vibration is reduced in humans carrying a dominant mutation in the c-MAF gene PMID: 22345400
- we studied the mechanisms underlying IL-2 regulation of C-MAF expression in human T cells PMID: 21876034
- Hepatitis C virus impairs the induction of cytoprotective Nrf2 target genes by delocalization of small Maf proteins. PMID: 21216956
- the MEK-ERK pathway regulates MAF transcription PMID: 21163924
- Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein PMID: 21362551
- Monocyte-derived macrophages with CD14 of high-antigen positivity display increased expression of c-Maf, which upregulates production of two key factors (hyaluronan and interleukin-10) that promote growth of Mycobacterium tuberculosis. PMID: 21209279
- c-Maf interacts with Ubc9 & PIAS1. c-Maf can be SUMOylated at Lys-33 in vitro. SUMOylation attenuates its transcriptional activity. PMID: 20127678
- Taken together, these studies demonstrate a new level of transcriptional regulation of MMP-13 expression by the c-maf. PMID: 20067416
- novel role for MAF as a transcriptional repressor, preventing expression of blood vessel endothelial cells-specific genes, thereby maintaining the differentiation status of lymphatic endothelial cells PMID: 20080955
- results suggest that Tc-mip plays a critical role in Th2 signaling pathway and represents the first proximal signaling protein which links TCR-mediated signal to the activation of c-maf Th2 specific factor PMID: 12939343
- The short form of the proto-oncogene c-maf is highly induced in minimal change nephrotic syndrome T cells during relapse, where it translocates to the nuclear compartment and binds to the DNA responsive element. PMID: 14688382
- High levels of c-maf mRNA is associated with multiple myeloma PMID: 14692531
- c-maf transforms plasma cells by stimulating cell cycle progression and by altering bone marrow stromal interactions PMID: 14998494
- role of c-Maf in the transcriptional regulation of IL-10 and the underlying molecular mechanism in macrophages PMID: 15749884
- results suggest that c-Maf might cause a type of T-cell lymphoma in both mice and humans and that ARK5, in addition to cyclin D2 and integrin beta(7), might be downstream target genes of c-Maf leading to malignant transformation PMID: 16424013
- Findings expand the mutation spectrum of MAF in association with congenital cataract and highlight the genetic and phenotypic heterogeneity of congenital cataract. PMID: 16470690
- Segmental allergen challenge in asthmatics leads to increased GATA-3, c-maf and T-bet expression in BAL cells but not in bronchial biopsies PMID: 16498264
- OPN is significantly upregulated in MM patients with maf translocations, particularly in the fraction lacking bone disease PMID: 17044113
- c-Maf is capable of interactions with c-Myb that lead to reduced promoter binding and decreased Bcl-2 expression, rendering CD4 T cells more prone to apoptosis. PMID: 17823980
- the differential DNA binding specificity between Maf homodimers and Nrf2-Maf heterodimers establishes the differential gene regulation by these dimer-forming transcription factors PMID: 17875642
- CD13 transcription is regulatd by MAF via an atypical response element. PMID: 17897790
- Pax-6 and c-Maf interact with G1 to activate basal expression of the glucagon gene PMID: 17901057
- MAF mutation p.Arg299Ser is the third mutation identified in association with the CCMC phenotype, and all three mutations are located in the basic region of the DNA binding domain in the MAF protein (OMIM 177075). PMID: 17982426
- Angioimmunoblastic T-cell lymphoma(AILT) shows c-Maf expression and provide new insight into the pathogenesis of AILT suggesting c-Maf to be a useful diagnostic marker. PMID: 18059226
- MafG-mediated nuclear retention may enable Nrf2 proteins to evade cytosolic proteasomal degradation and consequently stabilize Nrf2 signaling PMID: 18585411
- The exclusion of these genes as likely candidates supports the hypothesis that the ocular phenotype associated with peters' anomaly segregating in this family is a distinct, new, autosomal dominant entity in the anterior segment dysgenesis spectrum. PMID: 18616618
- In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene), near MAF (encoding the transcription factor c-MAF) and near PTER (phosphotriesterase-related gene). PMID: 19151714
- c-maf may be important in chondrocyte hypertrophy and terminal differentiation, and may be involved in the pathogenesis of osteoarthritis PMID: 19215682
- detection of c-Maf may be of particular value in the differential diagnosis of small cell lymphomas. PMID: 19687312
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相關疾病：Cataract 21, multiple types (CTRCT21); Ayme-Gripp syndrome (AYGRP)
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亞細胞定位：Nucleus.
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蛋白家族：BZIP family, Maf subfamily
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組織特異性：Expressed in endothelial cells.
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數據庫鏈接：
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