LYL1 Antibody
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中文名稱(chēng)：LYL1兔多克隆抗體
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貨號(hào)：CSB-PA009891
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規(guī)格：￥1090
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：LYL1
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別名：bHLHa18 antibody; Class A basic helix-loop-helix protein 18 antibody; Lyl1 antibody; LYL1_HUMAN antibody; Lymphoblastic leukemia derived sequence 1 antibody; Lymphoblastic leukemia-derived sequence 1 antibody; lymphoblastomic leukemia 1 antibody; Protein lyl 1 antibody; Protein lyl-1 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human Lyl-1.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution IHC 1:100-1:300 ELISA 1:10000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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相關(guān)產(chǎn)品
靶點(diǎn)詳情
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基因功能參考文獻(xiàn)：
- Despite not being identified as an independent prognostic factor in UCEC, LYL1 gene amplification is associated with other poor prognostic factors and correlated with upregulation of cancer-related pathways. PMID: 29716549
- In t(8;21) leukemia cells, LYL1 functions as a component of the stable AML1-ETO-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis. PMID: 23812588
- LYL1 degradation is directed by a N-terminal PEST rich site in a phosphorylation-independent manner. PMID: 20844761
- LYL1 activity is required for the maturation of newly formed blood vessels in adulthood. PMID: 20418284
- Over-expression of LYL1 is highly associated with AML as well as ALL. PMID: 19176012
- Multiple mechanisms which activate LYL1 in leukemic cells, including structural genomic alterations, namely microdeletion or amplification, together with the involvement of prominent oncogenic transcription factors. PMID: 19608273
- LYL1 may play a role in early hematopoiesis and may be a potential oncogenic factor in AML PMID: 16094422
- Lyl1 interacts with CREB1 and alters expression of CREB1 target genes. PMID: 18160048
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相關(guān)疾病：A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.
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亞細(xì)胞定位：Nucleus.
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數(shù)據(jù)庫(kù)鏈接：
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