LY96 Antibody, FITC conjugated

說明書

中文名稱：

LY96兔多克隆抗體, FITC偶聯
貨號：

CSB-PA013254LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) LY96 Polyclonal antibody
Uniprot No.：

Q9Y6Y9
基因名：

LY96
別名：

ESOP 1 antibody; ESOP-1 antibody; ESOP1 antibody; LY 96 antibody; Ly-96 antibody; LY96 antibody; LY96_HUMAN antibody; Lymphocyte antigen 96 antibody; md 2 antibody; MD 2 protein antibody; MD2 protein antibody; Myeloid differentiation protein 2 antibody; Protein MD 2 antibody; Protein MD-2 antibody; Protein MD2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Lymphocyte antigen 96 protein (19-160AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS.
基因功能參考文獻：
1. sTLR4/MD-2 complex inhibits colorectal cancer migration and invasiveness in vitro and in vivo by lncRNA H19 down-regulation. PMID: 29036538
2. MD-2 siRNA or plasmid further confirmed the efficacy of Iturin A by suppressing MD-2/TLR4 signaling pathway. The in silico docking study showed that the Iturin A interacted well with the MD-2 in MD-2/TLR4 receptor complex. Conclusively, inhibition of MD-2/TLR4 complex with Iturin A offered strategic advancement in cancer therapy. PMID: 28347875
3. data confirm that engineered human cells expressing TLR4, MD2 and CD14 can respond to CMP with NF-kappaB activation and the response can be influenced by variations in CMP-mannosylation PMID: 29281684
4. The observations suggest that MD-2 helps to regulate lipopolysaccharide-induced NLRP3 inflammasome activation and the inflammatory response in NR8383 cells, and likely does so by affecting MyD88/NF-kappaB signaling. PMID: 28654770
5. MD2 plays an important role in induction of allergic sensitization to cat dander and common pollens relevant to human allergic diseases. PMID: 26586036
6. we report that exogenous CnB is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4/MD2 complex together with the co-receptor CD14 PMID: 27090571
7. In this study, a novel naturally occurring spliceosome of human MD2, termed as MD2-T3, has been identified. PMID: 27317890
8. Results show that cigarette smoke may alter innate immune responses reducing the expression of the MD2, a molecule with an important role in TLR4 signaling. PMID: 26068048
9. Predominantly hydrophobic interactions between MD-2 and TLR4 contribute to the stabilization of the TLR4/MD-2/metal ion complex in a conformation that enables activation. PMID: 25803856
10. The intensity of the intra-amniotic inflammatory response to bacteria or perhaps to other TLR4 ligands may be facilitated through synthesis and release of sMD2 by the amniochorion. PMID: 25605324
11. Three genes (LY96, IL8 DPR) were significantly downregulated over time. This finding was confirmed in a validation cohort of stroke patients (n=8). PMID: 25124890
12. The study revealed the impact of specific residues and regions of MD-2 on the binding of lipolysaccharides and TLR4. PMID: 26320630
13. Gene polymorphisms of MD2 and GM2A were associated with the occurrence or severity of neonatal necrotizing enterocolitis. PMID: 25816011
14. In patients undergoing CABG surgery, we found genetic polymorphisms in LY96 associated with decreased risk of postoperative AF. PMID: 26385043
15. Aminoarabinose residues in lipid A contribute to Burkholderia lipid A binding to the TLR4.Myeloid Differentiation Factor 2 complex. PMID: 26160169
16. TLR4 along with its accessory protein MD-2 builds a heterodimeric complex that specifically recognizes lipopolysaccharides, which are present on the cell wall of gram-negative bacteria, activating the immune response. (Review) PMID: 25515751
17. genetic polymorphism is associated with asthma exacerbations in children PMID: 24902762
18. In monocytes of sepsis, MD-2 expression was found to be regulated by STAT1. PMID: 24858600
19. Substitution of hMD-2 residue V82 with an amino acid residue with a bulkier hydrophobic side chain enables activation of TLR4/MD-2. PMID: 25203747
20. This study suggests that genetic variants of LY96 may modulate the effect of smoking on carotid plaque burden. PMID: 24954085
21. overexpression of MD-2s led to marked reduction in markers of tissue injury and inflammation in models of lung inflammation PMID: 25576596
22. Purified monomeric ligand.MD-2 complexes reveal molecular and structural requirements for activation and antagonism of TLR4 by Gram-negative bacterial endotoxins. PMID: 24895101
23. Studies suggest that myeloid differentiation 2 (MD-2) as a therapeutic target for sepsis. PMID: 24896325
24. Mechanistically, engagement of MD-2 by PTX3-opsonized Aspergillus conidia activated the TLR4/Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent signaling pathway converging on IL-10. PMID: 25049357
25. Collectively, these data showed for the first time that, HIV-1 Tat interacts physically with high affinity with TLR4-MD2 to promote proinflammatory cytokines (TNF-alpha) and the immunosuppressive cytokine IL-10 both. PMID: 24165011
26. Data suggest that zhankuic acid A (ZAA), which competes with LPS for binding to MD-2 as a TLR4/MD-2 antagonist, may be a potential therapeutic agent for gram-negative bacterial infections. PMID: 24532584
27. these findings indicate that MD-2 is involved in IFN-gamma signalling and IFN-gamma-augmented MMP-1 up-regulation by LPS. PMID: 23800176
28. Extracellular complex formation of TLR4 with secreted MD-2 was detectable using monoclonal antibodies. PMID: 24021278
29. both oral and enteric C. concisus strains upregulated expression of TLR4 and MD-2 in HT-29 cells. PMID: 23437263
30. Consistently, soluble TLR4 expressed without MD2 inhibited metal- but not LPS-induced responses, opening new therapeutic perspe PMID: 23059983
31. Respiratory syncytial virus F protein requires MD-2 for the induction of the TLR4-mediated inflammatory response. PMID: 22872782
32. In LOS.MD-2 complexes, one of the six fatty acyl chains of LOS is more susceptible to paramagnetic attenuation, suggesting protrusion of that fatty acyl chain from the hydrophobic pocket of MD-2, independent of association with TLR4. PMID: 22433852
33. Lipopolysaccharide cytokine response was efficiently and equally abolished by MD-2 and CD14 neutralization; the response induced by whole E. coli bacteria was only modestly reduced by MD-2 neutralization, whereas CD14 neutralization was more efficient. PMID: 21948372
34. have identified specific structural and dynamic features of the MD-2-endotoxin complexes that may control dimerization of TLR4 molecules. PMID: 21924775
35. The association between occupational endotoxin exposure and wheeze in agricultural workers was significantly modified by genetic variants in CD14 and MD2 PMID: 21389010
36. Data demonstrate that during bacterial infection, newborns amplify the TLR2-MyD88 pathway in G+ bacterial infection and the TLR4/MD2/MyD88 pathway in G- bacterial infection, implicating the innate immune pathway in response to bacterial infection. PMID: 20805788
37. higher expression levels in tissue from patients with colorectal cancer PMID: 20699280
38. Computational study of the interactions of the unmodified dendrimer, glucosamine, and of the partially glycosylated dendrimer with TLR4 and MD-2 using molecular docking and molecular dynamics techniques. PMID: 21738462
39. tyrosine phosphorylation of MD-2 is important for signaling following exposure to lipopolysaccharide PMID: 21918188
40. Cytokines can enhance TLR4 and MD-2 expressions and promote the reaction with LPS in intestinal epithelial cells. PMID: 20848773
41. Interferon-gamma-induced MD-2 protein expression and lipopolysaccharide (LPS) responsiveness in corneal epithelial cells is mediated by Janus tyrosine kinase-2 activation and direct binding of STAT1 protein to the MD-2 promoter. PMID: 21572044
42. In this study, we produced variants of MD-1 and MD-2 in Pichia pastoris. PMID: 21130168
43. Innate immune recognition of meningococcal capsular polysaccharides by macrophages can occur via TLR2- and TLR4-MD-2 pathways. PMID: 21191086
44. Neisserial lipooligosaccharides from different meningococcal and gonococcal strains have different potencies to activate NF-kappaappaB through the Toll-like receptor 4-MD-2 pathway in monocytes. PMID: 21037101
45. Data conclude that these gene variants in the MD-2 gene promoter region are not associated with tuberculosis, and apparently do not play a role in susceptibility to tuberculosis in the Chinese population. PMID: 20730709
46. species-specific activation of lipid IV(A) PMID: 20592019
47. increased expression in intestinal epithelial cells in patients with inflammatory bowel disease PMID: 19710105
48. In this study, we have identified a novel alternatively spliced isoform of human MD-2, termed MD-2 short (MD-2s), which lacks the region encoded by exon 2 of the MD-2 gene. PMID: 20435923
49. Polymorphisms of the promoter region of MD-2 gene at position - 1625 C/G is correlated with MODS and sepsis after severe trauma in Chinese Han population. PMID: 19209789
50. sMD-2 and sCD14 inhibit the growth of both Gram-positive and Gram-negative bacteria. PMID: 20377740
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亞細胞定位：

Secreted, extracellular space. Secreted.
數據庫鏈接：

HGNC: 17156

OMIM: 605243

KEGG: hsa:23643

STRING: 9606.ENSP00000284818

UniGene: Hs.726603

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