LRSAM1 Antibody
-
中文名稱：LRSAM1兔多克隆抗體
-
貨號：CSB-PA751010ESR2HU
-
規(guī)格：￥440
-
圖片：
-
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA751010ESR2HU at dilution of 1:100
-
-
其他：
產(chǎn)品詳情
-
產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) LRSAM1 Polyclonal antibody
-
Uniprot No.：
-
基因名：LRSAM1
-
別名：CMT2P antibody; E3 ubiquitin protein ligase LRSAM1 antibody; E3 ubiquitin-protein ligase LRSAM1 antibody; EC 6.3.2.- antibody; FLJ31641 antibody; hTAL antibody; Leucine rich repeat and sterile alpha motif containing 1 antibody; Leucine rich repeat and sterile alpha motif containing protein 1 antibody; Leucine-rich repeat and sterile alpha motif-containing protein 1 antibody; LRSAM1 antibody; LRSM1_HUMAN antibody; OTTHUMP00000022174 antibody; OTTHUMP00000022175 antibody; RIFLE antibody; TAL antibody; Tsg101 associated ligase antibody; Tsg101-associated ligase antibody
-
宿主：Rabbit
-
反應(yīng)種屬：Human
-
免疫原：Recombinant Human E3 ubiquitin-protein ligase LRSAM1 protein (1-290AA)
-
免疫原種屬：Homo sapiens (Human)
-
標(biāo)記方式：Non-conjugated
-
克隆類型：Polyclonal
-
抗體亞型：IgG
-
純化方式：Antigen Affinity Purified
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
-
產(chǎn)品提供形式：Liquid
-
應(yīng)用范圍：ELISA, IHC
-
推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
功能：E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy).
-
基因功能參考文獻(xiàn)：
- We identified a novel LRSAM1 missense mutation (c.2120C > T, p.Pro707Leu) mapping to the RING domain. The identified missense mutation, as well as of another recently reported pathogenic missense mutation (c.2081G > A, p.Cys694Tyr), revealed that in vitro ubiquitylation activity was largely abrogated. PMID: 28335037
- findings suggest that the mutant LRSAM1 may aberrantly affect the formation of transcription machinery. PMID: 27615052
- findings demonstrate that the isolated genetic entity Charcot-Marie-Tooth type 2G is caused by a missense mutation in LRSAM1. PMID: 27686364
- LRSAM1 exhibited self-association in vitro and in vivo. The study found the self-association of LRSAM1 promotes intermolecular ubiquitination and proved a potential N-terminal ubiquitination. PMID: 28189685
- disruption of the C-terminal RING domain confers dominant negative properties to LRSAM1 PMID: 24894446
- Our data further confirms that LRSAM1 mutations are associated with CMT2 of AD inheritance. PMID: 22781092
- Authors identify LRSAM1 as the E3 ligase responsible for anti-Salmonella autophagy-associated ubiquitination. PMID: 23245322
- homozygous mutation in LRSAM1 was proposed as a strong candidate for the disease in a family with recessive axonal polyneuropathy PMID: 22012984
- LRSAM1 as a component of the antibacterial autophagic response. PMID: 20616063
- LRSAM1 is a strong candidate for the causal gene for the Charcot-Marie-Tooth disease. PMID: 20865121
- Results suggest that RIFLE represents a novel signaling protein that mediates components of the Wnt/wingless signaling pathway and cell adhesion in PC12 cells [RIFLE protein]. PMID: 14635195
- Tal regulates a Tsg101-associated complex responsible for the sorting of cargo into cytoplasm-containing vesicles that bud at the multivesicular body and at the plasma membrane PMID: 15256501
- Tal polyubiquitinates lysine residues in the C-terminus of uncomplexed Tsg101, resulting in proteasomal degradation. PMID: 18077552
顯示更多
收起更多
-
相關(guān)疾病：Charcot-Marie-Tooth disease 2P (CMT2P)
-
亞細(xì)胞定位：Cytoplasm.
-
組織特異性：Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue.
-
數(shù)據(jù)庫鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
