LMTK2 Antibody
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中文名稱：LMTK2兔多克隆抗體
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貨號：CSB-PA022099
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規格：￥2024
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圖片：
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Western blot analysis of extracts from LOVO cells, using LMTK2 antibody. -
Immunohistochemistry analysis of paraffin-embedded human brain tissue using LMTK2 antibody. -
Immunofluorescence analysis of HepG2 cells, using LMTK2 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) LMTK2 Polyclonal antibody
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Uniprot No.：
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基因名：LMTK2
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from internal of Human LMTK2.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 IF 1:100-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Phosphorylates PPP1C, phosphorylase b and CFTR.
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基因功能參考文獻：
- both BIM and BCL2 proteins are regulated by LMTK2 in a GSK3beta- and PP1A-dependent manner. PMID: 28040547
- Mutation of the di-acidic export motif led to endoplasmic reticulum retention of LMTK2, and an increase in protein half-life. PMID: 26559041
- Lemur Tyrosine Kinase-2 (LMTK2), negatively regulates androgen-dependent and androgen-independent prostate cancer cell proliferation. In addition, LMTK2 also negatively regulates the androgen receptor transcriptional activity. PMID: 26008968
- Data indicate that Lemur tyrosine kinase 2 (LMTK2) localizes at the plasma membrane and co-immunoprecipitates with cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells. PMID: 24727471
- The results indicate that lemur tyrosine kinase 2 is an integral membrane protein in which both the amino and carboxyl termini are exposed to the cytoplasm. Moreover, this topology places the kinase active site within the cytoplasm. PMID: 23114966
- We describe a new signalling pathway within the nervous system that links cdk5/p35 with phosphatase-1C and which has implications for a number of neuronal functions and neuronal dysfunction PMID: 22220831
- Low LMTK2 expression is associated with the development of prostate cancer. PMID: 20569440
- KPI-2 is a kinase with sites to associate with PP1C and Inh2 to form a regulatory complex that is localized to membranes PMID: 12393858
- Cprk is expressed in a number of tissues but is enriched in brain and muscle; Cprk displays catalytic activity in kinase assays and is itself phosphorylated by cdk5/p35; Cdk5/p35 inhibits cprk activity PMID: 12832520
- BREK, Brain Enriched Kinase, is a new member of the family of protein serine/threonine kinases; plays important roles in NGF-TrkA signalling in the brain [BREK] PMID: 15005709
- role of the segment KLHY in binding with protein phosphatase 1 PMID: 16428298
- Myosin VI and LMTK2 are required for the transport of cargo, such as the Transferrin Receptor, from early endosomes to the endocytic recycling compartment. PMID: 18029400
- Results show that BREK is critical for the transition of endocytosed membrane vesicles from early endosomes to recycling endosomes and also suggest an involvement of myosin VI in this pathway. PMID: 18429820
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亞細胞定位：Membrane; Multi-pass membrane protein.
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蛋白家族：Protein kinase superfamily, Tyr protein kinase family
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組織特異性：Mainly expressed in skeletal muscle, and weakly in brain and pancreas.
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數據庫鏈接：
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