LAX1 Antibody

說明書

產品詳情

Uniprot No.：

Q8IWV1
基因名：

LAX1
別名：

LAX1 antibody; LAX antibody; Lymphocyte transmembrane adapter 1 antibody; Linker for activation of X cells antibody; Membrane-associated adapter protein LAX antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human LAX1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.
基因功能參考文獻：
1. TRIM required LAX for binding to Rab8 in a complex, a novel CTLA-4/TRIM/LAX/Rab8 effector complex in the transport of CTLA-4 to the surfaces of T cells PMID: 24515439
2. We identified the transmembrane domain of LAX as a first motif targeting transmembrane protein constructs to detergent-resistant heavy rafts, a novel type of membrane microdomains containing a number of physiologically important proteins. PMID: 22662118
3. functions to negatively regulate signaling in lymphocytes PMID: 12359715
4. inhibition of signaling events involved in T cell activation by LAX occurs through mechanisms both dependent on and independent of its tyrosine phosphorylation. PMID: 18981125
5. Overexpression of LAX in Jurkat cells specifically inhibits T cell receptor-mediated p38 MAPK activation and NFAT/AP-1 transcriptional activation. PMID: 12359715
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亞細胞定位：

Cell membrane; Single-pass type III membrane protein.
組織特異性：

Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines.
數據庫鏈接：

HGNC: 26005

KEGG: hsa:54900

STRING: 9606.ENSP00000406970

UniGene: Hs.272794

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