LAMA5 Antibody

文獻引用 (1) 說明書

中文名稱：

LAMA5兔多克隆抗體
貨號：

CSB-PA009767
規格：

￥1090
圖片：
Western Blot analysis of RAW HepG2 A549 cells using Laminin α-5 Polyclonal Antibody
其他：

產品詳情
產品評價
引用文獻
相關產品
靶點詳情

產品詳情

Uniprot No.：

O15230
基因名：

LAMA5
別名：

KIAA0533 antibody; KIAA1907 antibody; LAMA5 antibody; LAMA5_HUMAN antibody; Laminin alpha 5 chain antibody; Laminin subunit alpha 5 antibody; Laminin subunit alpha-5 antibody; Laminin; alpha 5 antibody; Laminin-10 subunit alpha antibody; Laminin-11 subunit alpha antibody; Laminin-15 subunit alpha antibody; RP11-157P1.6 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human Laminin α-5.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Withania somnifera root extract inhibits MGO-induced skin fibroblast cells dysfunction via ECM-integrin interaction X Liu, C Chen, Y Lin, Y Liu, S Cai, D Li, L Li, P Xiao, F Yi,Journal of Ethnopharmacology,2024

產品評價

靶點詳情

功能：

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
基因功能參考文獻：
1. The finding of rare LAMA5 variants together with FLT4 and FOXC2 mutations in Milroy disease and lymphedema-distichiasis syndrome suggests that these mutations may be co-responsible for these disorders and most likely interfere with the function of lymphatics. PMID: 29908552
2. This study shows that specific laminin alpha5 substrates provide a controlled in vitro culture environment for human pluripotent stem cells-derived neurons. PMID: 28926760
3. study describes the first LAMA5 mutation that causes a novel complex extracellular matrix syndrome PMID: 28735299
4. data show that the BCAM/LAMA5 system plays a functional role in the metastatic spreading of KRAS-mutant colorectal cancer PMID: 27143691
5. Taken together, these data suggest that alpha5-containing laminins repress intestinal differentiation in its early stages. PMID: 29198708
6. We report here a severe defect of neuromuscular transmission in a consanguineous patient with a homozygous variant in the laminin alpha-5 subunit gene (LAMA5). The variant c.8046C>T (p.Arg2659Trp) is rare and has a predicted deleterious effect. The affected individual, who also carries a rare homozygous sequence variant in LAMA1, had muscle weakness, myopia, and facial tics PMID: 28544784
7. The Laminin-511 consists of alpha5, beta1, and gamma1 chains, of which three laminin globular domains of the alpha5 chain (alpha5/LG1-3) and a Glu residue in the C-terminal tail of chain gamma1 (gamma1-Glu1607) are required for binding to integrins. PMID: 28412362
8. The association of LAMA5 rs4925386 alleles with both inter-individual differences in height and in longevity suggests that laminins may be among the factors linking stature and cancer susceptibility. PMID: 26968355
9. disruption of the LAMA5 gene dramatically reduced hPSC self-renewal and increased apoptosis without affecting the expression of pluripotency markers. PMID: 26235893
10. Gal-1 decreased the expression of collagen genes COL3A1 and COL5A1 but increased the expression of fibronectin and laminin 5. PMID: 24503541
11. Lutheran (Lu), also known as basal cell adhesion molecule (B-CAM), competes with integrins for binding to laminin alpha5, a subunit of LM-511, a major component of basement membranes. PMID: 24036115
12. The laminin-5 staining pattern was significantly more often continuous in severe dysplasia/carcinoma-in-situ PMID: 23715200
13. mechanistic role of laminin-511 in tissue homeostasis PMID: 22666383
14. Polymorphisms in LN5 were associated with a reduced level of hemoglobin and neutropenia in non-small cell lung cancer. PMID: 21461966
15. These results indicate specific laminin isoforms and integrins in maintenance of human embryonic stem cells pluripotency in feeder-dependent cultures. PMID: 22099024
16. PDGF-BB is not superior to laminin as a potential marker of advanced CP. PMID: 21921666
17. Data indicate that the function-blocking antibody against Lu/B-CAM should be useful for not only investigating cell adhesion to laminin alpha5 but also for developing drugs to inhibit sickle cell vaso-occlusion. PMID: 21858073
18. Cytoplasmic and basement membrane laminin is important in the pathogenesis and invasion of basal cell carcinoma. PMID: 19615022
19. investigated the relation between epithelial-mesenchymal transition criteria and laminin-332 expression in a cell culture model of transforming growth factor beta-1 (TGFbeta1)/epithelial growth factor (EGF) long time co-stimulation. PMID: 20819124
20. Abnormal distribution of laminin alpha1 and laminin alpha5 in glomerular basement membrane is correlated with GBM thickening and splitting in human Alport's syndrome. PMID: 20019771
21. LAMA5 rs659822 regulates anthropometric and metabolic traits in elderly people PMID: 20951195
22. Data from experiment with peptide fragments suggest laminin alpha5 (and laminin alpha4) may be part of host defense response and may protect tissues from invading pathogens. PMID: 20433883
23. Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways (Laminin 10; separate entry for Laminin 11). PMID: 11891225
24. LN5 has a role in the differentiation of the tracheal epithelium in human embryos PMID: 12242717
25. LN6 and LN5 have distinct biological activities, but they may cooperatively support cell adhesion PMID: 12379663
26. role for laminin-5 during human embryogenesis, for example, for epithelial cell development, beyond its involvement in hemidesmosome formation and cell adhesion. PMID: 12382139
27. Laminins with alpha1, alph4, and alpha5 chains are compared to determine laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. PMID: 12393739
28. Our results elucidate a mechanism whereby mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane. PMID: 12682087
29. Data suggest that laminin-10 (alpha5beta1gamma1) is required for hair follicle development and report the first use of exogenous protein to correct a cutaneous developmental defect. PMID: 12743034
30. Incubation of mouse macrophages with human laminin alpha5 chain peptide results in marked increase in matrix metalloproteinase-9 mRNA and gelatinolytic activity; this peptide is chemotactic for mouse neutrophils and macrophages in vitro and in vivo. PMID: 12817023
31. Autocrine LM-5 mediates anchorage-independent survival in breast tumors through ligation of a wild-type, but not a cytoplasmic tail-truncated alpha6beta4 integrin. PMID: 14691145
32. prostate cancer cells expressing high levels of MT1-MMP have increased invasive potential through their ability to degrade and invade Ln-10 barriers PMID: 15967115
33. Protein kinase A-dependent phosphorylation of Lutheran/basal cell adhesion molecule glycoprotein regulates cell adhesion to laminin alpha5 PMID: 15975931
34. An increase was noted in LAMA5 immunostaining in the dilated muscle of the ganglionic bowel upstream the distal aganglionic region in a group of Hirschprung disease patients. PMID: 16226104
35. Results describe the expression of laminin 5 by parental and c-Ha-ras-transformed HaCaT keratinocytes in organotypic cultures. PMID: 16460839
36. laminin 5 and p16INK4A have roles in wound healing and senescence PMID: 16723698
37. The results indicate that glioma cells secrete alpha2-, alpha4- and alpha5-laminins and that alpha3- and alpha5-laminins, selectively promote glioma cell migration and identify alpha3beta1 as the predominant integrin and laminin receptor in glioma cells. PMID: 17888902
38. alpha5-laminin was the most adhesion- and migration-promoting isoform for human blood lymphocytes, followed by alpha3- (Lm-332) and alpha4- (Lm-411) laminins. PMID: 18523231
39. These results suggest that laminins containing alpha 5 serve as functional substrates regulating progression of hepatocellular carcinoma. PMID: 18635166
40. results suggest an evolutionarily conserved role of a member of the laminin gene family in contributing to variation in weight and body composition PMID: 18694491
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亞細胞定位：

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
組織特異性：

Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver.
數據庫鏈接：

HGNC: 6485

OMIM: 601033

KEGG: hsa:3911

STRING: 9606.ENSP00000252999

UniGene: Hs.473256

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