LAMA4 Antibody, HRP conjugated
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中文名稱：LAMA4兔多克隆抗體, HRP偶聯
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貨號：CSB-PA621948LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) LAMA4 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：CMD1JJ antibody; DKFZp686D23145 antibody; LAMA3 antibody; LAMA3, formerly antibody; LAMA4 1 antibody; LAMA4 antibody; LAMA4*-1 antibody; LAMA4_HUMAN antibody; Laminin alpha 4 antibody; Laminin alpha 4 chain antibody; Laminin subunit alpha 4 precursor antibody; Laminin subunit alpha-4 antibody; Laminin-14 subunit alpha antibody; Laminin-8 subunit alpha antibody; Laminin-9 subunit alpha antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Laminin subunit alpha-4 protein (1593-1823AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
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基因功能參考文獻：
- High LAMA4 expression is associated with gastric cancer. PMID: 30015861
- Disruption of LAMA4, LAMA5, and LAMB2 or the laminin-receptor interaction occurs in neuromuscular diseases including Pierson syndrome and Lambert-Eaton myasthenic syndrome (LEMS). (Review) PMID: 27614294
- highlight MCAM and LAMA4 as prime candidates for RCC prognosis and therapeutic targeting PMID: 26921326
- LAMA4-integrin signalling affects chondrocyte morphology and gene expression, contributing to cluster formation in osteoarthritic chondrocytes. PMID: 26295200
- LAMA4 expression is lowered in preeclamptic placentas and promotes trophoblast cell invasion, migration, and angiogenesis. hypoxia-reoxygenation decreases LAMA4 expression and decouple the relationship between LAMA4 expression and p38 and ERK activation. PMID: 26059342
- Oxidative stress plays a vital role in controlling expression of LAMA4 through MAPK signaling pathways, which suggests a possible pathological mechanism of pre-eclampsia. PMID: 25676580
- Laminins 411 and 421 differentially promote tumor cell migration via alpha6beta1 integrin and MCAM (CD146). PMID: 24951930
- Data from experiment with peptide fragments suggest laminin alpha4 (and laminin alpha5) may be part of host defense response and may protect tissues from invading pathogens. PMID: 20433883
- Laminins with alpha1, alpha4, and alpha5 chains are compared to determine laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. PMID: 12393739
- Data report the identification of a splice variant of the human laminin alpha4 subunit transcript containing 21 extra nucleotides. PMID: 12445830
- The G domain of laminin alpha4 chain is a specific, high affinity ligand for alphavbeta3 & alpha3beta1 integrin heterodimers. These integrins, with alpha6beta1, cooperatively mediate endothelial cell-alpha4 laminin interaction & blood vessel development. PMID: 12454288
- The alpha4 laminin subunit regulates vascular endothelium cell survival. PMID: 14980521
- laminin alpha4 LG4 module may play an important role in cell adhesion and/or vessel wall formation in the skin by interacting with syndecan-2 and/or -4. PMID: 15086543
- Downregulation of laminin alpha4 chain expression inhibits glioma invasion PMID: 15915502
- laminin isoform changes are associated with brain tumor invasion and angiogenesis [review] PMID: 16146715
- This suggests that G(1121-1139) peptide-containing proteins may perform their biological functions by interacting with alphavbeta3 integrin. PMID: 16824487
- alpha4 chain Lms have a de-adhesive function and could thus play a role in detachment, migration and invasion of renal carcinoma cells in vivo. PMID: 17533363
- 2 novel mutations (2828C>T [Pro943Leu] & 3217C>T [Arg1073X]) in the integrin-interacting domain of the LAMA4 gene reduce its integrin binding, & cause endothelial cell loss and heart failure. PMID: 17646580
- LAMA4 is specifically up-regulated on both mRNA and protein levels in hepatocelluar carcinoma; potential role in hepatocarcinogenesis and tumor progression. PMID: 18084776
- Concomitant changes take place in laminin- and collagen-binding receptors. Laminin-411 reduces adhesion to laminin-511 and fibronectin, suggesting that tumor cells could utilize laminin-411 in their invasive behavior PMID: 18496706
- LM alpha4 and beta2 have roles in in vitro migration and in vivo tumorigenicity of prostate cancer cells PMID: 19048114
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相關疾病：Cardiomyopathy, dilated 1JJ (CMD1JJ)
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亞細胞定位：Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
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組織特異性：In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn t
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