KYNU Antibody, HRP conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) KYNU Polyclonal antibody
Uniprot No.：

Q16719
基因名：

KYNU
別名：

kynU antibody; KYNU_HUMAN antibody; kynureninase (L-kynurenine hydrolase) antibody; Kynureninase antibody; L-kynurenine hydrolase antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Kynureninase protein (99-214AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
基因功能參考文獻：
1. Our results suggest that tryptophan metabolism might dichotomously modulate immune responses, with KYNU as a switch between immunosuppressive versus inflammatory outcomes. PMID: 26725996
2. A rare variant at the KYNU gene is associated with essential hypertension in the Han Chinese population. PMID: 22012986
3. The Lys412Glu polymorphism of the KYNU gene in a hypertensive candidate chromosomal region is associated with essential hypertension in Han Chinese. PMID: 16080802
相關疾病：

Hydroxykynureninuria (HYXKY); Vertebral, cardiac, renal, and limb defects syndrome 2 (VCRL2)
亞細胞定位：

Cytoplasm, cytosol.
蛋白家族：

Kynureninase family
組織特異性：

Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions.
數據庫鏈接：

HGNC: 6469

OMIM: 236800

KEGG: hsa:8942

STRING: 9606.ENSP00000264170

UniGene: Hs.470126

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