KIR2DS3 Antibody

中文名稱：

KIR2DS3兔多克隆抗體
貨號：

CSB-PA613530LA01HU
規格：

￥440
圖片：
Immunofluorescent analysis of PC-3 cells using CSB-PA613530LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) KIR2DS3 Polyclonal antibody
Uniprot No.：

Q14952
基因名：

KIR2DS3
別名：

KIR2DS3 antibody; NKAT7Killer cell immunoglobulin-like receptor 2DS3 antibody; MHC class I NK cell receptor antibody; Natural killer-associated transcript 7 antibody; NKAT-7 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Killer cell immunoglobulin-like receptor 2DS3 protein (102-241AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，KIR2DS3 Antibody (CSB-PA613530LA01HU)，的標記方式是Non-conjugated。對于KIR2DS3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA613530LB01HU	KIR2DS3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA613530LC01HU	KIR2DS3 Antibody, FITC conjugated
Biotin	CSB-PA613530LD01HU	KIR2DS3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
基因功能參考文獻：
1. activating KIR2DS3 was associated with rapid leukocyte engraftment after hematopoietic stem cell transplantation from matched sibling PMID: 28993188
2. Genotypes missing these two inhibitory KIR-HLA combinations in addition to missing activating KIRs 2DS2 and 2DS3 were more common in Vogt-Koyanagi-Harada disease (OR = 1.90, P = 0.002). PMID: 27490240
3. Loss of KIR2DS3 gene is associated with breast cancer. PMID: 27631728
4. genetic polymorphism is associated with childhood acute lymphoblastic leukemia among north Indians PMID: 26472014
5. The genes KIR2DL5, KIR2DS3 and KIR2DS5 were present in a significantly higher proportion of individuals in the asymptomatic control group than in the malaria cases. PMID: 24929143
6. the presence of host genetic risk factors, IL28B-T and KIR2DS3 alleles, resulted in increased odds of treatment failure in these rapid virological response negative patients. PMID: 23826153
7. KIR2DS3 and HLA-class I alleles (-Cw*14 and -Cw*17) may play a role in the pathogenesis of the Vogt-Koyanagi-Harada disease. PMID: 22219647
8. The Natural Killer cell gene KIR2DS3 was significantly increased in patients with chronic hepatitis C virus infection. PMID: 21402922
9. KIR2DS3 is associated with protection against acute myeloid leukemia. PMID: 20371915
10. Positive linkage disequilibrium was seen between KRI2DS2 and KIR2DS3. Positive linkage disequilibrium was seen between KIR3DS1 and KIR2DS3. PMID: 12559621
11. KIR2DS3 is a protective factor for chronic graft-versus-host disease. PMID: 17462498
12. This focuses on the inheritance of KIR2DS3*001 and *002 to clarify their genetic relationship, and will investigate the diversity of haplotypes containing a KIR2DS3 gene. PMID: 18480828
13. Genomic and mRNA sequences support the KIR2DS3*002 gene being a hybrid of KIR2DS3*00103 and KIR2DS5. PMID: 18764809
14. Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule. PMID: 19005473
15. KIR2DS3 incompatibilities increased risk of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation PMID: 19500138
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Immunoglobulin superfamily
數據庫鏈接：

HGNC: 6335

OMIM: 604954

KEGG: hsa:3808

UniGene: Hs.744266

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