KIF3A Antibody

說明書

中文名稱：

KIF3A兔多克隆抗體
貨號：

CSB-PA236618
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA236618(KIF3A Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA236618(KIF3A Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse brain tissue, human fetal brain tissue, human brain malignant glioma tissue, Primary antibody: CSB-PA236618(KIF3A Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9Y496
基因名：

KIF3A
別名：

KIF 3 antibody; KIF 3A antibody; KIF3 antibody; Kif3a antibody; KIF3A_HUMAN antibody; Kifl antibody; Kinesin family member 3A antibody; Kinesin family protein 3 antibody; Kinesin family protein 3A antibody; Kinesin like protein KIF 3A antibody; Kinesin like protein KIF3A antibody; Kinesin-like protein KIF3A antibody; Kns3 antibody; Microtubule plus end directed kinesin motor 3A antibody; Microtubule plus end-directed kinesin motor 3A antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Fusion protein of Human KIF3A
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:200-1:1000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.
基因功能參考文獻：
1. KIF3A plays an important role in epithelium apoptosis and bronchial inflammation in asthma PMID: 29156524
2. A correlation between KIF3A loss and a poorer NSCLC prognosis as well as beta-catenin and cyclin D1 upregulation further suggests that KIF3A suppresses Wnt/beta-catenin signalling and tumourigenesis in NSCLC PMID: 27596264
3. The rate of transport is set by an equilibrium between a faster state, where only kinesin family member 17 protein (KIF17) motors move the train, and a slower state, where at least one kinesin family member 3A/B protein (KIF3AB) motor on the train remains active in transport. PMID: 28761002
4. p0071 is required for directional vesicle movement and secretion of different KIF3-transported carriers, thereby regulating the transport of intracellular membrane vesicles along microtubules. PMID: 28808088
5. PLCD1 acts as a tumour suppressor, by KIF3A-mediated suppression of ERK1/2/beta-catenin/MMP7 signalling, at least in part, in breast cancer. PMID: 28423710
6. Inhibition of kif3a in the human dental follicle cells (hDFCs) and human dental pulp cells (hDPCs) is disrupted primary cilia formation and/or function, and it was shown that kif3a is important in the differentiation of hDFCs and hDPCs through the Wnt pathway. PMID: 27432616
7. High KIF3A expression is associated with glioblastoma. PMID: 26760767
8. These data suggest that GLI interactions with KIF3A-KIF3B-KAP3 complexes are essential for proper GLI transcriptional activity. PMID: 25588831
9. KIF3A and OVOL1 are involved in the development of Atopic dermatitis in the Chinese pediatric population. PMID: 26127003
10. both motor domains of KIF3A/B coordinate for processive motility and move at different speeds PMID: 15345558
11. Ablation of this phosphorylation abolished herpes simplex virus 1 US3-mediated downregulation of CD1d expression, suggesting that phosphorylation of KIF3A is the primary mechanism of viral suppression of CD1d expression. PMID: 25878107
12. Findings support the notion that upregulation of KIF3a is causal of aberrant activation of Wnt signaling in advanced prostate cancer through the KIF3a-DVL2-beta-catenin axis. PMID: 24413182
13. POPX2 affects trafficking by determining the phosphorylation status of KIF3A at serine 690. PMID: 24338362
14. Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients PMID: 23278845
15. in addition to its ciliogenic roles, Kif3a recruits p150(Glued) to the subdistal appendages of mother centrioles, critical for centrosomes to function as microtubule-organizing centres. PMID: 23386061
16. KIF3A is a novel candidate gene for childhood asthma PMID: 21912604
17. Our findings suggest that the KIF3A gene and/or its polymorphisms might have a susceptibility effect on aspirin-intolerant asthma (AIA). PMID: 20922562
18. Variants carried by the haplotypes of SLC22A4, SLC22A5 and KIF3A region potentially contribute to tuberculosis susceptibility among the Thai population. PMID: 20485362
19. KIF3, cilia, and nodal flow have roles in left-right determination [review] PMID: 20066075
20. Required for the normal steady-state localization of late endosomes/lysosomes but not early endosomes or recycling endosomes. PMID: 16262723
21. Interaction of KIF3A/3B with KAP3 may be important for the proper progression of mitosis. PMID: 16298999
22. We detected ALS-specific down-regulation of KIF1Bbeta and novel KIF3Abeta, two isoforms we show to be enriched in the brain, and also of SOD1, a key enzyme linked to familial ALS PMID: 17418584
23. Rip11/FIP5-kinesin-II complex plays a key role in the routing of internalized receptors through the perinuclear recycling endosomes. PMID: 18957512
24. Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion. PMID: 19043453
25. This study thus reports on transportation of KSHV viral complexes on microtubules by KIF3A PMID: 19282970
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亞細胞定位：

Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Kinesin II subfamily
數據庫鏈接：

HGNC: 6319

OMIM: 604683

KEGG: hsa:11127

STRING: 9606.ENSP00000368020

UniGene: Hs.43670

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