KIF15 Antibody, Biotin conjugated

說明書

中文名稱：

KIF15兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA868310LD01HU
規格：

￥880
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) KIF15 Polyclonal antibody
Uniprot No.：

Q9NS87
基因名：

KIF15
別名：

KIF15 antibody; KLP2 antibody; KNSL7Kinesin-like protein KIF15 antibody; Kinesin-like protein 2 antibody; hKLP2 antibody; Kinesin-like protein 7 antibody; Serologically defined breast cancer antigen NY-BR-62 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Kinesin-like protein KIF15 protein (1-129AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.
基因功能參考文獻：
1. KIF15 knockdown using short hairpin RNA in two human lung adenocarcinoma cell lines induced G1/S phase cell cycle arrest and inhibited cell growth. PMID: 30439711
2. The non-motor microtubule-binding tail domain interacts with the microtubule's E-hook tail with a rupture force higher than the stall force of the motor. This allows Kif15 dimers to productively and efficiently generate forces that could potentially slide microtubules apart. PMID: 28918951
3. Both Kif15 and KBP are required for the alignment of all the chromosomes to the metaphase plate and the assembly of stable kinetochore fibers of the correct length. PMID: 28445502
4. This study identified KIF15 as a critical regulator that promotes pancreatic cancer proliferation, broadening our understanding of KIF15 function in tumorigenesis. PMID: 28595260
5. To our knowledge, KIF15 is the first kinesin to be associated with congenital thrombocytopenia. PMID: 28150392
6. KIF15 is involved in alternative spindle assembly pathways. PMID: 27091450
7. When intersecting microtubules are parallel, Kif15 motors can drive (biased) parallel sliding because the motor simultaneously steps on both microtubules that it cross-links. PMID: 26969727
8. These data reveal that hKif15 is a plus-end-directed processive homotetramer that can step against loads of up to 3.5 pN. PMID: 24668168
9. Eg5, Kif15, and dynein work together to build a bipolar spindle and reveal an important role for antagonistic motors in chromosome segregation. PMID: 25127142
10. regulates alpha2 integrin internalization PMID: 24659801
11. Although Kif15 contains ADP in the catalytic site, its motor-domain structure was captured in the ;ATP-like' configuration, with the neck linker docked to the catalytic core. PMID: 24419385
12. By examining Kif15 activity in two cellular contexts, it was found that Kif15 bound to kinetochore fibers antagonizes centrosome separation while Kif15 bound to nonkinetochore MTs mediates centrosome separation. PMID: 23791727
13. Pole separation depends on Hklp2/Kif15, an otherwise dispensable plus end-directed spindle motor and results in spindles with two centrosomal poles. PMID: 22024925
14. Kif15 can replace all essential functions of Eg5 in bipolar spindle assembly. PMID: 19818618
15. Hklp2 participates in the assembly and stabilization of the bipolar spindle. PMID: 19818619
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亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton, spindle.
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, KLP2 subfamily
組織特異性：

Expressed in testis, colon, thymus and in breast cancer.
數據庫鏈接：

HGNC: 17273

OMIM: 617569

KEGG: hsa:56992

STRING: 9606.ENSP00000324020

UniGene: Hs.658939

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