KHDRBS3 Antibody
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中文名稱：KHDRBS3兔多克隆抗體
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貨號(hào)：CSB-PA012156ESR2HU
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規(guī)格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA012156ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA012156ESR2HU at dilution of 1:100
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) KHDRBS3 Polyclonal antibody
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Uniprot No.：
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基因名：KHDRBS3
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別名：Etle antibody; etoile antibody; KH domain containing RNA binding signal transduction associated 3 antibody; KH domain containing RNA binding signal transduction associated protein 3 antibody; KH domain-containing antibody; KHDR3_HUMAN antibody; Khdrbs3 antibody; RNA binding protein T Star antibody; RNA-binding antibody; RNA-binding protein T-Star antibody; SALP antibody; Sam68 like mammalian protein 2 antibody; Sam68 like phosphotyrosine protein antibody; Sam68 like phosphotyrosine protein T STAR antibody; Sam68-like mammalian protein 2 antibody; Sam68-like phosphotyrosine protein antibody; signal transduction-associated protein 3 antibody; SLM 2 antibody; SLM-2 antibody; SLM2 antibody; T STAR antibody; TSTAR antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human KH domain-containing, RNA-binding, signal transduction-associated protein 3 protein (177-346AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in splice site selection of vascular endothelial growth factor. In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members. Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity. May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing. Can bind FABP9 mRNA. May play a role as a negative regulator of cell growth. Inhibits cell proliferation.; (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression.
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基因功能參考文獻(xiàn)：
- Down-regulating the KHDRBS3 gene can cause G0/G1 phase arrest and inhibit cell proliferation in CAOV-3 cells. PMID: 28871947
- Sam68 and T-STAR could regulate alternative splicing of some pre-mRNAs by bringing two distant UAA motifs into proximity and looping out regions of the pre-mRNA. PMID: 26758068
- Nuclear T-STAR protein expression correlates with HER2 status, hormone receptor negativity and prolonged recurrence free survival in primary breast cancer and decreased cancer cell growth in vitro. PMID: 23923007
- SerpinB5 interacts with KHDRBS3 and FBXO32, and KHDRBS3 can interact with FBXO32 mRNA. PMID: 21725612
- SLM-2-dependent VEGF splicing indicates the importance of mRNA splice site selection for glomerular filtration barrier function. PMID: 15901763
- The T-STAR gene may participate in regulation of telomerase activity in human colon cancer HCT-116 cells in a parallel fashion. PMID: 16810759
- data implicate hsa-miR-30b, hsa-miR-30d and KHDRBS3 as putative oncogenic target(s) of a novel recurrent medulloblastoma amplicon at 8q24.22-q24.23 PMID: 19584924
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亞細(xì)胞定位：Nucleus. Note=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.
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蛋白家族：KHDRBS family
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組織特異性：Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis.
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數(shù)據(jù)庫(kù)鏈接：
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