KEL Antibody
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中文名稱：KEL兔多克隆抗體
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貨號：CSB-PA012148LA01HU
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規格：￥440
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圖片：
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Western blot
All lanes: KEL antibody at 3µg/ml + HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 83 kDa
Observed band size: 83 kDa -
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA012148LA01HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) KEL Polyclonal antibody
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Uniprot No.：
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基因名：KEL
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別名：KEL; Kell blood group glycoprotein; CD antigen CD238
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Kell blood group glycoprotein protein (201-500AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，KEL Antibody (CSB-PA012148LA01HU)，的標記方式是Non-conjugated。對于KEL Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.
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基因功能參考文獻：
- Ten new silent KEL alleles were identified in Japanese individuals with the Ko phenotype. PMID: 29280152
- description of four new KEL*01M alleles PMID: 26996808
- The expression of Kell glycoprotein on RBCs is not critical to the erythrocyte function PMID: 26308465
- Through molecular genotyping we also identified polymorphisms in RhCE, Kell, Duffy, Colton, Lutheran and Scianna loci in donors and patients. PMID: 25582271
- A relatively increased KEL1 antigen expression in KEL:1,2null and KEL:1,2mod individuals suggest that the expression of Kell-XK complexes depends on the availability of the XK protein. PMID: 25156717
- High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry-based blood group genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles. PMID: 24845979
- After sequencing the whole KEL gene, we found three new missense mutations: c.455A>G (p.Tyr152Cys) at Exon 5, c.2111A>C (p.Pro704His) at Exon 19, and c.1726G>C (p.Gly576Arg) at Exon 16. PMID: 25041236
- A new allele, KEL(Thr193Met, Pro326Leu), has a drastic effect on the Kell glycoprotein probably due to defects in protein trafficking or reduced membrane integration. PMID: 24588083
- Sequence analysis of genomic DNA from 2 Caucasian Brazilian women revealed a new homozygous change in KEL Exon 2, a guanine to an adenine substitution at Position 71 (c.71G>A, NCBI_ss#: 831878329) leading to a premature stop codon. PMID: 24506314
- A compensatory mechanism of the KELmod allele deficient expression in heterozygote patients may exist. Retrospective analysis of 80,000 subjects showed a local KEL:1,-2 frequency 4 times lower than expected. PMID: 23727116
- A rare allele in this family has been numbered KEL*02M.04 and contains a Gly703Arg substitution that appears to cause weakened expression of Kell antigens and a Kmod phenotype when in trans with a null allele in the propositus. PMID: 24795954
- Systematic DNA analysis showed that the number of discordant phenotype/genotype results, related to silent KEL*02 alleles was higher than expected in France. PMID: 23581578
- These findings identify the translational start site and define the full cytoplasmic tail of the human Kell glycoprotein. PMID: 23721226
- Novel IVS6-13C>T mutation recognized as a cause of discrepancy between phenotyping and genotyping in KEL*3,4 polymorphism identification. PMID: 20609202
- x-ray analysis of Kell blood group protein PMID: 12842980
- Kell K2 antigen is a catalytically active metalloprotease, but the rare Kell K1 antigen is inactive PMID: 15769748
- KEL6 red blood cells have endothelin-3-converting enzyme activity PMID: 16423827
- Results demonstrate the lack of Kell expression in rodent neuronal cells and strongly suggest the same for human cerebral tissue, in which the Kellprotein was exclusively observed on RBCs in cerebral blood vessels. PMID: 17379193
- This is the first description of the KEL*1,3 allele encoding KEL1 and KEL3 on the same molecule. PMID: 19347978
- In screening 87665 unrelated healthy blood donors in China, two K(0) probands were detected; in exon 3, 185insT (Ser62Phe and a premature stop codon in exon 4 PMID: 19747286
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亞細胞定位：Cell membrane; Single-pass type II membrane protein. Note=Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.
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蛋白家族：Peptidase M13 family
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組織特異性：Expressed at high levels in erythrocytes and testis (in Sertoli cells), and, at lower levels, in skeletal muscle, tonsils (in follicular dendritic cells), lymph node, spleen and appendix (at protein level). Also expressed in many adult and fetal nonerythr
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