KCNQ3 Antibody, HRP conjugated

說明書

中文名稱：

KCNQ3兔多克隆抗體, HRP偶聯
貨號：

CSB-PA012091LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) KCNQ3 Polyclonal antibody
Uniprot No.：

O43525
基因名：

KCNQ3
別名：

BFNC 2 antibody; BFNC antibody; BFNC2 antibody; EBN 2 antibody; EBN2 antibody; KCNQ 3 antibody; KCNQ3 antibody; KCNQ3_HUMAN antibody; KQT like 3 antibody; KQT-like 3 antibody; KV7.3 antibody; Potassium channel subunit alpha KvLQT3 antibody; Potassium channel voltage gated subfamily Q member 3 antibody; Potassium voltage gated channel KQT like protein 3 antibody; Potassium voltage gated channel KQT like subfamily member 3 antibody; Potassium voltage gated channel subfamily KQT member 3 antibody; Potassium voltage-gated channel subfamily KQT member 3 antibody; Voltage gated potassium channel subunit Kv7.3 antibody; Voltage-gated potassium channel subunit Kv7.3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Potassium voltage-gated channel subfamily KQT member 3 protein (763-872AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability.
基因功能參考文獻：
1. Phylogenetic analysis, electrostatic potential mapping, in silico docking, electrophysiology, and radioligand binding assays reveal that the anticonvulsant binding pocket evolved to accommodate endogenous neurotransmitters including gamma-aminobutyric acid, which directly activates KCNQ5 and KCNQ3 via W265. PMID: 29748663
2. Tannic acid activates Kv7.4 and Kv7.3/7.5 K(+) channels resulting in vasodilation. PMID: 26969140
3. Carboxyl terminus helix C-D linker residues play a role in KCNQ3 current amplitudes by controlling the exit of the KCNQ3 channel from the endoplasmic reticulum. PMID: 26692086
4. In bipolar disorder patients' prefrontal cortex, Kcnq3 expression was decreased, DNA methylation was decreased, and Kcnq3 mRNA was decreased compared to controls. PMID: 25041603
5. the clinical and EEG features of this patient further on expand the phenotypic variability of KCNQ3 gene mutations PMID: 25278462
6. mutations in KCNQ3, similarly to KCNQ2, can be found in patients with more severe phenotypes including intellectual disability PMID: 25524373
7. We monitored KCNQ2/3 channel currents and translocation of PHPLCdelta1 domains as real-time indicators of PM PI(4,5)P2, and translocation of PHOSH2x2, and PHOSH1 domains as indicators of plasma membrane and Golgi PI(4)P, respectively. PMID: 24843134
8. This study demonistrated that benign neonatal sleep myoclonus can show autosomal dominant inheritance but not allelic to KCNQ3. PMID: 22447848
9. KCNQ3 mutations might be involved in families with infantile seizures. PMID: 23360469
10. Data show that KCNQ3 and KCNE5 mRNA expressions were significantly upregulated in preeclampsia. PMID: 21730298
11. Different structural determinants, identified at the N and C termini of KCNQ3, prevent the effects of syntaxin 1A and calmodulin, respectively. PMID: 21976501
12. This study reported that the presence of this uncommon residue at position 315 has a strong impact on the stability of the homotetramers and on channel trafficking. PMID: 20610766
13. There may be a genetic contribution of this gene in juvenile myoclonic epilepsy in a South Indian population. PMID: 12928862
14. Several BFNC mutations of KCNQ2 and KCNQ3 disrupt surface expression or polarized surface distribution of KCNQ channels, thereby revealing impaired targeting of KCNQ channels to axonal surfaces as a benign familial neonatal convulsions (BFNC) etiology. PMID: 16735477
15. ICA-27243 is a novel and selective KCNQ3 potassium channel activator. PMID: 18089837
16. The expression of KCNQ3 increased in late fetal life to infancy in brain. PMID: 18166285
17. This study identified a novel missense mutation of KCNQ3, c.988C>T located within exon 6. c.988C>T led to the substitution Cys for Arg in amino acid position 330 (p.R330C) in KCNQ3 potassium channel. PMID: 18249525
18. A three-dimensional homology model in the W309R mutant indicated that the R side chain of pore helices is too far from the Y side chain of the selectivity filter to interact via hydrogen bonds with each other and stabilize the pore structure. PMID: 18425618
19. Sequence variations of the KCNQ2 (and KCNQ3)genes may contribute to the etiology of common idiopathic epilepsy syndromes. PMID: 18625963
20. among the allowed assembly conformations are KCNQ3/4 and KCNQ4/5 heteromers. PMID: 18786918
21. most wild-type channels are functionally silent, with rearrangements of the pore-loop architecture induced by the presence of a hydroxyl-containing residue at the 315 position "unlocking" the channels into a conductive conformation PMID: 18790849
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相關疾病：

Seizures, benign familial neonatal 2 (BFNS2)
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Potassium channel family, KQT (TC 1.A.1.15) subfamily, Kv7.3/KCNQ3 sub-subfamily
組織特異性：

Predominantly expressed in brain.
數據庫鏈接：

HGNC: 6297

OMIM: 121201

KEGG: hsa:3786

STRING: 9606.ENSP00000373648

UniGene: Hs.374023

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