KANK2 Antibody
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中文名稱：KANK2兔多克隆抗體
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貨號：CSB-PA178754
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規格：￥2024
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圖片：
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Immunohistochemistry analysis of paraffin-embedded human heart tissue using KANK2 antibody. -
Immunofluorescence analysis of A549 cells, using KANK2 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) KANK2 Polyclonal antibody
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Uniprot No.：
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基因名：KANK2
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from internal of Human KANK2.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,IHC,IF
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推薦稀釋比：
Application Recommended Dilution IHC 1:50-1:100 IF 1:100-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway. May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney. Through the Rho signaling pathway may also regulate cell proliferation.
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基因功能參考文獻：
- Using whole-exome sequencing, authors identified a homozygous missense c.2009C>T mutation in KANK2 PMID: 24671081
- SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. PMID: 17476305
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相關疾病：Palmoplantar keratoderma and woolly hair (PPKWH)
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亞細胞定位：Cytoplasm. Mitochondrion.
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組織特異性：Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level).
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數據庫鏈接：
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