Idh1 Antibody
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中文名稱：Idh1兔多克隆抗體
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貨號：CSB-PA010989LA01MO
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規(guī)格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA010989LA01MO at dilution of 1:50 -
Immunofluorescent analysis of MCF-7 cells using CSB-PA010989LA01MO at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Mus musculus (Mouse) Idh1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Idh1 antibody; Isocitrate dehydrogenase [NADP] cytoplasmic antibody; IDH antibody; EC 1.1.1.42 antibody; Cytosolic NADP-isocitrate dehydrogenase antibody; IDP antibody; NADP(+)-specific ICDH antibody; Oxalosuccinate decarboxylase antibody
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宿主：Rabbit
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反應(yīng)種屬：Mouse
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免疫原：Recombinant Mouse Isocitrate dehydrogenase [NADP] cytoplasmic protein (1-240AA)
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免疫原種屬：Mus musculus (Mouse)
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標(biāo)記方式：Non-conjugated
本頁面中的產(chǎn)品，Idh1 Antibody (CSB-PA010989LA01MO)，的標(biāo)記方式是Non-conjugated。對于Idh1 Antibody，我們還提供其他標(biāo)記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IHC, IF
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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基因功能參考文獻(xiàn)：
- Vitamin C treatment induced an IDH1(R132H)-dependent reduction in cell proliferation. PMID: 28663574
- IDH1 expression regulates TCA cycle in glioma and affects glioma cell growth.GDH2 promotes growth of IDH1-expressing gliomas. PMID: 29097607
- Through the use of a conditional mutant mouse model that confers a less aggressive tumor phenotype, findings provide new insight into the effects of mutant Idh1 on a candidate cell of origin for glioma, mutant Idh1's role in disrupting the microenvironment from which gliomas arise, and mutant Idh1's effect on the course of glioma progression. PMID: 28148827
- IDH1 mutations caused down-regulation of leukocyte chemotaxis, resulting in repression of the tumor-associated immune system. PMID: 28465358
- Idh1(R132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling gliomagenesis PMID: 27693047
- Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1, enzymes involved in the TCA cycle, were elevated. PMID: 27380194
- data suggest that mutant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of malignant T cells PMID: 26787889
- The results suggest that Idh1 has a physiological function in protecting cells from oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. PMID: 25882048
- These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations R132H. PMID: 25849072
- MiR-181a regulates lipid metabolism via IDH1 PMID: 25739786
- revealed a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity. PMID: 25218477
- these data show that mutant IDH or d-2HG causes persistence of chondrocytes, giving rise to rests of growth-plate cells that persist in the bone as enchondromas. PMID: 25730874
- WA might exert its chemopreventive activity via inhibiting not only oncogenic activation, but also IDH1 inactivation. PMID: 23107437
- Brain-specific Idh1-KI mice show brain hemorrhage accompanied by high D2HG levels but decreased ROS PMID: 22925884
- Suggest that decreased IDPc expression renders melanocytes more vulnerable to oxidative stress, and IDPc plays an important antioxidant function in melanocytes. PMID: 22264756
- Absence of IDH1 mutations in low-grade gliomas (LGGs) identifies a novel entity of LGGs with distinctive location, infiltrative behavior, specific molecular alterations, and dismal outcome. PMID: 21080178
- a possible association between IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia. PMID: 20861910
- IDPc would be a major NADPH producer required for fat and cholesterol synthesis. PMID: 15254034
- The results suggest that IDPc plays an important protective role in apoptosis of HL-60 cells induced by singlet oxygen. PMID: 17646934
- IDPc is expressed differentially along tubules in patterns that may contribute to differences in susceptibility to injury, major enzyme in cytosolic NADPH generation in kidney, downregulated with ischemia-reperfusion PMID: 19106211
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亞細(xì)胞定位：Cytoplasm, cytosol.
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蛋白家族：Isocitrate and isopropylmalate dehydrogenases family
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數(shù)據(jù)庫鏈接：
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