Idh1 Antibody

中文名稱：

Idh1兔多克隆抗體
貨號：

CSB-PA010989LA01MO
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA010989LA01MO at dilution of 1:50

Immunofluorescent analysis of MCF-7 cells using CSB-PA010989LA01MO at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Mus musculus (Mouse) Idh1 Polyclonal antibody
Uniprot No.：

O88844
基因名：

Idh1
別名：

Idh1 antibody; Isocitrate dehydrogenase [NADP] cytoplasmic antibody; IDH antibody; EC 1.1.1.42 antibody; Cytosolic NADP-isocitrate dehydrogenase antibody; IDP antibody; NADP(+)-specific ICDH antibody; Oxalosuccinate decarboxylase antibody
宿主：

Rabbit
反應(yīng)種屬：

Mouse
免疫原：

Recombinant Mouse Isocitrate dehydrogenase [NADP] cytoplasmic protein (1-240AA)
免疫原種屬：

Mus musculus (Mouse)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，Idh1 Antibody (CSB-PA010989LA01MO)，的標(biāo)記方式是Non-conjugated。對于Idh1 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA010989LB01MO	Idh1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA010989LC01MO	Idh1 Antibody, FITC conjugated
Biotin	CSB-PA010989LD01MO	Idh1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

基因功能參考文獻(xiàn)：
1. Vitamin C treatment induced an IDH1(R132H)-dependent reduction in cell proliferation. PMID: 28663574
2. IDH1 expression regulates TCA cycle in glioma and affects glioma cell growth.GDH2 promotes growth of IDH1-expressing gliomas. PMID: 29097607
3. Through the use of a conditional mutant mouse model that confers a less aggressive tumor phenotype, findings provide new insight into the effects of mutant Idh1 on a candidate cell of origin for glioma, mutant Idh1's role in disrupting the microenvironment from which gliomas arise, and mutant Idh1's effect on the course of glioma progression. PMID: 28148827
4. IDH1 mutations caused down-regulation of leukocyte chemotaxis, resulting in repression of the tumor-associated immune system. PMID: 28465358
5. Idh1(R132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling gliomagenesis PMID: 27693047
6. Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1, enzymes involved in the TCA cycle, were elevated. PMID: 27380194
7. data suggest that mutant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of malignant T cells PMID: 26787889
8. The results suggest that Idh1 has a physiological function in protecting cells from oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. PMID: 25882048
9. These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations R132H. PMID: 25849072
10. MiR-181a regulates lipid metabolism via IDH1 PMID: 25739786
11. revealed a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity. PMID: 25218477
12. these data show that mutant IDH or d-2HG causes persistence of chondrocytes, giving rise to rests of growth-plate cells that persist in the bone as enchondromas. PMID: 25730874
13. WA might exert its chemopreventive activity via inhibiting not only oncogenic activation, but also IDH1 inactivation. PMID: 23107437
14. Brain-specific Idh1-KI mice show brain hemorrhage accompanied by high D2HG levels but decreased ROS PMID: 22925884
15. Suggest that decreased IDPc expression renders melanocytes more vulnerable to oxidative stress, and IDPc plays an important antioxidant function in melanocytes. PMID: 22264756
16. Absence of IDH1 mutations in low-grade gliomas (LGGs) identifies a novel entity of LGGs with distinctive location, infiltrative behavior, specific molecular alterations, and dismal outcome. PMID: 21080178
17. a possible association between IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia. PMID: 20861910
18. IDPc would be a major NADPH producer required for fat and cholesterol synthesis. PMID: 15254034
19. The results suggest that IDPc plays an important protective role in apoptosis of HL-60 cells induced by singlet oxygen. PMID: 17646934
20. IDPc is expressed differentially along tubules in patterns that may contribute to differences in susceptibility to injury, major enzyme in cytosolic NADPH generation in kidney, downregulated with ischemia-reperfusion PMID: 19106211
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亞細(xì)胞定位：

Cytoplasm, cytosol.
蛋白家族：

Isocitrate and isopropylmalate dehydrogenases family
數(shù)據(jù)庫鏈接：

KEGG: mmu:15926

STRING: 10090.ENSMUSP00000095316

UniGene: Mm.9925

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