IYD Antibody, Biotin conjugated
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中文名稱：IYD兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA754272LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) IYD Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：IYD antibody; C6orf71 antibody; DEHAL1 antibody; Iodotyrosine deiodinase 1 antibody; IYD-1 antibody; EC 1.21.1.1 antibody; Iodotyrosine dehalogenase 1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Iodotyrosine deiodinase 1 protein (24-147AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.
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基因功能參考文獻：
- The rate-limiting processes that contribute to the ability of flavin to promote reductive dehalogenation in human IYD. PMID: 26151430
- A switch between one- and two-electron chemistry of iodotyrosine deiodinase is controlled by substrate. PMID: 25395621
- Iodotyrosine deiodinase defect identified via genome-wide approach. PMID: 22535972
- high activity of human saliva peroxidase with iodide as a substrate may play a crucial role in the bioavailability and metabolism of biologically active iodide. PMID: 21870604
- Mutations in DEHAL1 leads to hypothyroidism, goiter and mental retardation (Review) PMID: 20298747
- molecular cloning and investigation of the localization and activity of DEHAL1 PMID: 15289438
- the cytoplasmic tail of DEHAL1 could play a role in the stability of the protein PMID: 16910871
- Diffuse cytoplasmatic localisation or downregulation of DEHAL1 expression in thyroid cancers suggests alteration or loss of DEHAL1 function during thyroid cell dedifferentiation. PMID: 17322488
- homozygous mutations in DEHAL1 appear to cause human iodotyrosine deiodinase deficiency, leading to hereditary hypothyroidism and goiter PMID: 18434651
- This study describes a functional mutation within IYD, demonstrating the molecular basis of the iodine wasting form of congenital hypothyroidism PMID: 18765512
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相關疾病：Thyroid dyshormonogenesis 4 (TDH4)
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亞細胞定位：Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane.
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蛋白家族：Nitroreductase family
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組織特異性：Expressed at a high level in thyroid gland (at protein level). Expressed at a high level in thyroid gland and at lower level in kidney and trachea.
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數據庫鏈接：
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