ITPR2 Antibody
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中文名稱：ITPR2兔多克隆抗體
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貨號：CSB-PA247118
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA247118(ITPR2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：4 antibody; 5-trisphosphate receptor antibody; Inositol 1 4 5 trisphosphate receptor type 2 antibody; Inositol 1,4,5-trisphosphate receptor type 2 antibody; Inositol 145 trisphosphate receptor type 2 antibody; InsP3 R2 antibody; InsP3R2 antibody; IP3 R2 antibody; IP3 receptor antibody; IP3 receptor isoform 2 antibody; IP3R 2 antibody; IP3R2 antibody; ITPR 2 antibody; Itpr2 antibody; ITPR2_HUMAN antibody; Type 2 inositol 1 4 5 trisphosphate receptor antibody; Type 2 inositol 1 antibody; Type 2 inositol 145 trisphosphate receptor antibody; Type 2 InsP3 receptor antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthetic peptide of Human ITPR2
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:10000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
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基因功能參考文獻：
- we systematically evaluating RCC risk-associated SNPs indentified from previous GWAS in a Chinese population, finding that one SNP located in PDZD2 and two SNPs located in ITPR2 were ccRCC-risk associated in Chinese population. PMID: 26918600
- Data suggest miR-1290 as the new oncomiR involved in laryngeal squamous cell carcinoma pathogenesis probably through downregulation of its target genes MAF and ITPR2. PMID: 26694163
- results show a functional role of calcium release by the ITPR2 channel and its subsequent accumulation in the mitochondria PMID: 24797322
- High expression of inositol 1,4,5-trisphosphate receptor, type 2 is associated with acute myeloid leukemia. PMID: 25779662
- Disrupting IP3R/Bcl-2 interaction therefore leads in those cells to increased Ca(2) release and apoptosis. Intriguingly, IP3R2 is not only implicated in apoptosis but also in the induction of senescence, another tumour-suppressive mechanism. PMID: 25499268
- A genome-wide association study identifies ITPR2 as a susceptibility gene for Kashin-Beck disease in Han Chinese. PMID: 25303641
- Loss of InsP3R2-mediated calcium release causes isolated anhidrosis in humans. PMID: 25329695
- ITPR2 and hypertrophy specific gene expression is regulated, in part, by a positive feedback regulation between InsP3R2 and calcineurin-NFATc signaling pathways. PMID: 24415751
- These data suggest that ER Ca(2+) released by IP(3) receptors may be detrimental in amyotrophic lateral sclerosis and that motor neurons are vulnerable to impaired Ca(2+) metabolism. PMID: 23131553
- Functional IP3R2s are expressed in the mouse sinoatrial node and could serve as an additional divalent calcium ion-dependent mechanism in modulating cardiac pacemaker. PMID: 21852551
- ITPR2 is a functional target gene of the BACH1 transcription factor according to ChIP-seq and knockdown analysis in HEK 293 cells. PMID: 21555518
- The result of this study suggested that ITPR2 that do not modulate the risk for SALS in the German population. PMID: 19464757
- The knock down of IP3R-2 significantly reduced the intracellular Ca2+ response and this reduced Ca2+ response did not affect the activation of CREB but significantly decreased the activation of NFAT. PMID: 21063100
- Dystrophic (RCDMD) human muscle cells show 5-fold overexpression of IP(3)R2 and down-regulation of IP(3)R3 compared with normal human muscle cells. PMID: 20395455
- Antibodies are detected most frequently in rheumatoid arthritis. PMID: 17437169
- Genetic variation is susceptibility factor for amyotrophic lateral sclerosis(ALS). Involved in glutamate-mediated neurotransmission, is one of main regulators of intracellular calcium concentrations, and has important role in apoptosis. PMID: 17827064
- Provide evidence for a functional role of the de novo coupling between hTRPC1 and IP3RII in the activation of store operated calcium entry in platelets. PMID: 18249094
- Parathyroid hormone communicates with IP(3)R via "cAMP junctions" that allow local delivery of a supramaximal concentration of cAMP to IP(3)R, directly increasing their sensitivity to IP(3). PMID: 18936250
- Elevated InsP(3)R2 expression was also detected in hearts from human patients with heart failure after ischemic dilated cardiomyopathy, as well as in aortic-banded hypertrophic mouse hearts. PMID: 19549843
- Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18519826
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相關疾病：Anhidrosis, isolated, with normal sweat glands (ANHD)
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亞細胞定位：Endoplasmic reticulum membrane; Multi-pass membrane protein.
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蛋白家族：InsP3 receptor family
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組織特異性：Isoform Short is found in skeletal muscle and heart.
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數據庫鏈接：
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