ITIH1 Antibody

中文名稱：

ITIH1兔多克隆抗體
貨號：

CSB-PA4779A0Rb
規格：

￥440
圖片：
IHC image of CSB-PA4779A0Rb diluted at 1:400 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ITIH1 Polyclonal antibody
Uniprot No.：

P19827
基因名：

ITIH1
別名：

H1P antibody; IATIH antibody; IGHEP1 antibody; Inter alpha (globulin) inhibitor H1 antibody; Inter alpha (globulin) inhibitor H1 polypeptide antibody; Inter alpha trypsin inhibitor heavy chain 1 antibody; Inter alpha trypsin inhibitor heavy chain H1 antibody; Inter-alpha-inhibitor heavy chain 1 antibody; Inter-alpha-trypsin inhibitor complex component III antibody; Inter-alpha-trypsin inhibitor heavy chain H1 antibody; ITI heavy chain H1 antibody; ITI-HC1 antibody; ITIH antibody; ITIH1 antibody; ITIH1_HUMAN antibody; Serum-derived hyaluronan-associated protein antibody; SHAP antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Inter-alpha-trypsin inhibitor heavy chain H1 protein (403-638AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ITIH1 Antibody (CSB-PA4779A0Rb)，的標記方式是Non-conjugated。對于ITIH1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA4779B0Rb	ITIH1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA4779C0Rb	ITIH1 Antibody, FITC conjugated
Biotin	CSB-PA4779D0Rb	ITIH1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.; Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.
基因功能參考文獻：
1. Furthermore, thrombin treatment of the inflammatory matrix leads to dissolution of HC-HA cable structures and abolishes leukocyte adhesion. These data establish a novel mechanism whereby thrombin cleavage of HC1 regulates the adhesive properties of an inflammatory HA matrix. PMID: 27679489
2. Data suggest that Mg2+ or Mn2+ (but not Ca2+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2) and a bikunin/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin binds adjacent to the two heavy chains. PMID: 26728454
3. The results of this study revealed that the shared genetic risk factors of both schizophrenia and major depressive disorder exist in ITIH family genes in the Han Chinese population. PMID: 24389398
4. Data indicate that TSG-6-mediated cross-linking of hyaluronan (HA) films is impaired in the presence of inter-alpha-inhibitor (IalphaI) and that this effect suppresses the TSG-6-mediated enhancement of HA binding to CD44-positive cells. PMID: 24005673
5. Human inter-alpha-inhibitor is a substrate for factor XIIIa and tissue transglutaminase. PMID: 21939789
6. Transfection into H460M Human large cell lung carcinoma line decreased tumor metastasis in nude mice PMID: 11807786
7. PTX3 directly interacts with inter-alpha-trypsin inhibitor and has a role in hyaluronan organization and cumulus oophorus expansion PMID: 17675295
8. The first systematic analysis on the differential expression of ITIH genes in human cancer, showing frequent downregulation that may be associated with initiation and/or progression of these malignancies. PMID: 18226209
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亞細胞定位：

Secreted.
蛋白家族：

ITIH family
數據庫鏈接：

HGNC: 6166

OMIM: 147270

KEGG: hsa:3697

STRING: 9606.ENSP00000273283

UniGene: Hs.420257

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