ITGB5 Antibody, HRP conjugated

說明書

中文名稱：

ITGB5兔多克隆抗體, HRP偶聯
貨號：

CSB-PA011889LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ITGB5 Polyclonal antibody
Uniprot No.：

P18084
基因名：

ITGB5
別名：

ITGB5; Integrin beta-5
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Integrin beta-5 protein (431-637AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.; (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.
基因功能參考文獻：
1. High ITGB5 expression is associated with cervical cancer. PMID: 26758421
2. FAK activity regulates beta5 integrin expression and anchorage-independent cell growth in ovarian carcinoma. PMID: 24899686
3. FRMD5 regulates tumor cell motility via a dual pathway involving FRMD5 binding to integrin beta5 tail and to ROCK1 PMID: 25448675
4. Immunohistochemical analysis for alphavbeta3, alphavbeta5 and alphavbeta6 integrin subunits was performed and correlated with Ki67 and hypoxia-inducible factor (HIF)-1alpha indexes PMID: 25150423
5. Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration PMID: 24997346
6. we demonstrated via antibody blocking experiments that aV b5 and a6 significantly promoted hESC attachment in 2%oxygen only, whereas blockage of CD44 inhibited cell attachment in 21% O2 alone PMID: 24455718
7. Brain metastases ITGB5 expression exhibits considerable heterogeneity according to tumor origin. PMID: 24294359
8. Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta. PMID: 24036928
9. molecular model of integrin b5 structure was prepared and stereo chemical model quality was checked. Integrin b5 active sites were identified based on insilico analysis tools. PMID: 23962022
10. BDNF enhances the migration of chondrosarcoma by increasing beta5 integrin expression through a signal transduction pathway that involves the TrkB receptor, PI3K, Akt, and NF-kappaB. PMID: 23874483
11. The top primary GWAS association of Airway hyperresponsiveness was in rs848788(P-value 7.2E-07) located within the ITGB5 genes. PMID: 23984888
12. Depletion of integrin beta5 in triple-negative breast carcinoma cells markedly reduced tumor take, growth and tumor angiogenesis, whereas reexpression of integrin beta5 rescued this phenotype; findings show a critical role for integrin beta5 in the tumorigenic potential of breast carcinoma cells PMID: 22824793
13. High beta5-integrin protein expression is associated with aggressive behavior in gastric cancer. PMID: 22561002
14. Letter: loss of integrin beta5 in polyomavirus positive Merkel cell carcinoma may influence cell adhesion/migration. PMID: 22503669
15. Cysteine-rich protein Cyr61 activates interleukin (IL)-6 production via the alphavbeta5/Akt/NF-kappaB signaling pathway in rheumatoid arthritis. PMID: 22547695
16. The beta5-integrin adhesions contribute to the TGFbeta-induced EMT and the tumorigenic potential of carcinoma cells. PMID: 20404485
17. p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration PMID: 20507994
18. Src kinase-mediated activation of STAT3 and subsequent angiogenic gene expression mediate the effects of integrin alpha v beta 5 and may be exploited to enhance the paracrine activities of circulating angiogenic cells. PMID: 20431064
19. Overexpression of the beta5 integrin in hematopoietic cells was associated with the inhibition of cell proliferation and apoptosis. PMID: 11877043
20. different beta5 integrins: repeated-FNK (FNKFNK764-769) and single-FNK (FNK764-766) amino acid sequences in the cytoplasmic domain. PMID: 15979906
21. Our studies suggest that the phagocytic function of beta5 integrin is regulated by an unconventional NPxY-talin-independent activation signal and argue for the existence of molecular switches in the beta5 cytoplasmic tail for adhesion and phagocytosis. PMID: 17963729
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Integrin beta chain family
數據庫鏈接：

HGNC: 6160

OMIM: 147561

KEGG: hsa:3693

STRING: 9606.ENSP00000296181

UniGene: Hs.13155

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