ITGAD Antibody
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中文名稱：ITGAD兔多克隆抗體
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貨號：CSB-PA011873GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：ITGAD antibody; Integrin alpha-D antibody; ADB2 antibody; CD11 antigen-like family member D antibody; Leukointegrin alpha D antibody; CD antigen CD11d antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Human CD11d
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.
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基因功能參考文獻：
- findings suggest that CD11d/CD18 upregulation on proinflammatory macrophages may represent a common mechanism for macrophage retention at inflammatory sites, thereby promoting chronic inflammation and disease development. PMID: 28500072
- These results expand the potential for CD11d to regulate lymphocyte migration and tissue retention, and illuminate the possibility of a previously unconsidered role for CD11d in leukocyte biology and disease. PMID: 27881604
- alpha(D)beta(2) is a major member of the integrin repertoire of both circulating and tissue myeloid leukocytes in humans PMID: 25415295
- The effects of anti-CD11d treatment improves functional recovery in a rat model of repeated concussion. PMID: 23414334
- the cross-talk between neutrophils and NK cells is mediated by ICAM-3 and CD11d/CD18, respectively. PMID: 21712539
- CD11d expression increased in the subcutaneous white adipose tissue of obese adult women; this appears to be a common feature of obesity. PMID: 21508205
- a longer isoform of gut-enriched Kruppel-like factor 4 (GKLF) we term GKLFa interacts with the CD11d promoter PMID: 15561714
- multiple CD11d domains play a role in controlling intracellular location and association with CD18. PMID: 19571252
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亞細胞定位：Membrane; Single-pass type I membrane protein.
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蛋白家族：Integrin alpha chain family
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組織特異性：Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.
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數據庫鏈接：
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