ITGA6 Antibody
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中文名稱：ITGA6兔多克隆抗體
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貨號：CSB-PA006199
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規格：￥1090
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圖片：
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Western Blot analysis of 3T3 cells using Integrin α6 Polyclonal Antibody -
Western Blot analysis of NIH-3T3 cells using Integrin α6 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Alpha6p antibody; CD49 antigen-like family member F antibody; CD49f antibody; Integrin alpha6B antibody; Integrin, alpha 6 antibody; ITA6_HUMAN antibody; ITGA6 antibody; ITGA6B antibody; Processed integrin alpha-6 antibody; VLA 6 antibody; VLA-6 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human Integrin α6.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
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基因功能參考文獻：
- RUNX1 regulates ITGA6 through a consensus RUNX1 binding motif in its promoter PMID: 28926098
- This study found a significant association between Hepatitis B virus (HBV)and integrin A6, which may be responsible for early migration and invasion of hepatocellular carcinoma (HCC). Thus, integrin A6 is a predictive marker for tumor recurrence and invasiveness of HBV-driven HCC PMID: 30010110
- alpha6-integrin is a matrix stiffness-regulated mechanosensitive molecule which confers an invasive fibroblast phenotype and mediates experimental lung fibrosis. PMID: 27535718
- N-glycosylation controlled the EGFR complex formation with integrin alpha5beta1 or alpha6beta4 PMID: 27641064
- ITGA6 might be involved in a mechanism that underlies radiation resistance and that ITGA6 could be a potential target for therapies aimed at overcoming radiation resistance in breast cancer. PMID: 27624978
- ITGA6 mRNA can be detected in stools of patients with colorectal cancers using droplet digital PCR. PMID: 28522907
- In particular, methylation levels of ITGA4, RERG, and ZNF671 could distinguish Nasopharyngeal carcinoma (NPC) patients from non-cancer nasopharyngeal epithelium (NNE) subjects. We identified the DNA methylation rates of previously unidentified NPC candidate genes. PMID: 28716111
- miR-92b/integrin alpha6/Akt axis controls the motility of esophageal squamous carcinoma cells. PMID: 28036265
- High ITGA6 expression is associated with colorectal cancer. PMID: 26895101
- During the past decades, many studies have provided evidence for a role of laminin-binding integrins in tumorigenesis, and both tumor-promoting and suppressive activities have been identified. (Review) PMID: 27562932
- alpha6 beta4 integrin promotes resistance of cancer cells to ferroptosis. PMID: 28972104
- Human pluripotent stem cells promote the expression of integrin alpha6beta1, and nuclear localization and inactivation of FAK to supports stem cell self-renewal. PMID: 26930028
- Results provide evidence that alpha3 and alpha6 integrins have significantly different internalization kinetics and that coordination exists between them for internalization in prostate cancer cells. PMID: 27509031
- IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R. PMID: 28873464
- By directly binding to the 3'UTRs of ITGA6 and ITGB1, we found miR-30e-5p to suppress mainly the adhesion of ITGA6 in CRC cells to laminin.Taken together, miR-30e-5p is a novel effector of P53-induced suppression of migration, invasion and metastasis PMID: 28656629
- The SALL4 - integrin alpha6 - integrin beta1 network promotes cell migration for metastasis via activation of focal adhesion dynamics in basal-like breast cancer cells. PMID: 27773610
- FACS analysis of primary human Benign Prostatic Hyperplasia tissues confirms expansion of CD49f basal epithelia in patients with Basal cell hyperplasia. PMID: 28795417
- Increased integrin alpha6beta4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancers. PMID: 27107458
- alpha6beta4 integrin is a positive regulator of collective cell migration of A549 cells through influence on signal pathways in leader cells. PMID: 27922761
- The translational blocking of alpha5 and alpha6 integrin subunits affects migration and invasion, and increases sensitivity to carboplatin of SKOV-3 ovarian cancer cell line. PMID: 28131812
- alpha6(high)/CD71(low) cells give rise to a thicker pluristratified epithelium with lower seeding density and display a low Ki67 positive cells number, showing that they have reached the balance between proliferation and differentiation. PMID: 28134816
- The A380T Single Nucleotide Polymorphism of the ITGA6 gene was not associated with breast cancer development in the analyzed population of Misiones, Argentina. PMID: 27763564
- Positive Thy1 and CD49f expression is significantly associated with the progression and poor prognosis of chondrosarcoma. PMID: 27155928
- Ahr ligand aminoflavone targets breast cancer cells with stem cell-like properties, at least in part by abolishing alpha6-integrin expression. PMID: 26996297
- Platelet-enhanced endothelial colony forming cell angiogenesis requires platelet tetraspanin CD151 and alpha6beta1 integrin signaling. PMID: 26749288
- these findings identify CD151 and its interactions with integrins a3 and a6 as potential therapeutic targets for inhibiting stemness-driving mechanisms and stem cell populations in Glioblastoma. PMID: 26992919
- Schwann cells in the tumor-nerve environment affect tumor cell migration and invasion through regulation of the laminin receptor A6B1 and its variant A6pB1. PMID: 26239765
- HIF-dependent regulation of ITGA6 is one mechanism by which sorting for CD49f (+) cells enhances cancer stem cells. PMID: 27001172
- CD49f is a marker of bone marrow mesenchymal stem cells and is correlated with changes in these stem cells under inflammatory conditions. PMID: 26013602
- Genetic and Immunohistochemical Expression of Integrins ITGAV, ITGA6, and ITGA3 As Prognostic Factor for Colorectal Cancer PMID: 26674523
- We here identify CD49f and CD34 as markers to permit selection of the stem/progenitor cell-like population from human myometrium PMID: 26108791
- integrin alpha6beta4 stimulates invasion by promoting autocrine EGFR signaling through transcriptional up-regulation of key EGFR family members and by facilitating HGF-stimulated EGFR ligand secretion PMID: 26381405
- Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway. PMID: 25825984
- syndecans remain anchored to the alpha6beta4 integrin via its cytoplasmic domain, but the activation of cell motility is disrupted PMID: 26350464
- Unique sites of interaction between alphavbeta6 and uPAR are most likely located in uPAR domains II and III. PMID: 25318615
- our observations suggest that miR-25 is a key regulator of invasiveness in human prostate cancer through its direct interactions with av- and a6-integrin expression PMID: 25858144
- ITGA3, ITGA6, ITGB3,ITGB4 and ITGB5 are associated with GC susceptibility (rs2675), ITGA3, ITGA6, ITGB3, ITGB4 and ITGB5 are associated with gastric cancer susceptibility tumor stage and lymphatic metastasis in Chinese Han population. PMID: 25472585
- These results indicate that mAbs to the laminin a4 globular domain are able to inhibit tumor cell adhesion and migration on laminins 411 and 421, and that alpha6beta1 integrin and MCAM bind a4-laminins at very close sites on the globular domain PMID: 24681327
- Primary osteosarcoma patient tumor cell populations expressing high levels of CD49f and low levels of CD90 produce an aggressive xenograft tumor in mice. PMID: 24802970
- PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton that link to triple-negative breast cancer migration. PMID: 24982892
- These data suggest that systemic targeting of the ITGA6-dependent function of established tumors in bone may offer a noncytotoxic approach to arrest the osteolytic progression of metastatic prostate cancer. PMID: 24739392
- Data indicate that integrin alpha6 repression by Kruppel-like factor-9 (KLF9) inhibits glioblastoma cell stemness and tumorigenicity. PMID: 25288800
- Inhibition of actin, FAK, and ILK expression resulted in significantly increased uPAR expression and the variant ITGA6p production in aggressive prostate and breast cancer cell lines. PMID: 25450398
- Integrin alpha6B-beta1 preferentially binds laminin 511 and this ligand-integrin ligation induces the TAZ nuclear localization and transcriptional activity. PMID: 25561492
- alpha6-integrin is required for hemangioma stem cellsadherence to laminin, vessel formation in vivo, and for homing to the liver. PMID: 24022922
- Role of N-terminal residues in Abeta interactions with integrin receptor and cell surface PMID: 24955499
- Necl-4 interacts in cis with integrin alpha6 beta4 through their extracellular regions and Necl-4 inhibited the phorbol ester-induced disassembly of hemidesmosomes PMID: 23611113
- NLGN1 and alpha6 integrin preferentially colocalize in the mature retinal vessels, whereas NLGN1 deletion causes an aberrant VE-cadherin, laminin and alpha6 integrin distribution in vessels PMID: 24860089
- Taken together, it was concluded that CD151 promotes the proliferation and migration of PC3 cells through the formation of CD151-integrin complex and the activation of phosphorylated ERK. PMID: 22684562
- The data presented herein clearly show that down regulation of ITGA6 gene in the human thymic epithelium triggers a complex cascade of effects upon the expression levels of several other cell migration-related genes. PMID: 24564203
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相關疾病：Epidermolysis bullosa letalis, with pyloric atresia (EB-PA)
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亞細胞定位：Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor.
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蛋白家族：Integrin alpha chain family
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組織特異性：Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limite
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