ITGA4 Antibody, FITC conjugated
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中文名稱：ITGA4兔多克隆抗體, FITC偶聯
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貨號：CSB-PA011867LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ITGA4 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：269C wild type antibody; Antigen CD49D, alpha 4 subunit of VLA 4 receptor antibody; CD49 antigen like family member D antibody; CD49 antigen-like family member D antibody; CD49d antibody; IA4 antibody; Integrin alpha 4 antibody; Integrin alpha 4 subunit antibody; Integrin alpha IV antibody; Integrin alpha-4 antibody; Integrin alpha-IV antibody; Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA 4 receptor) antibody; ITA4_HUMAN antibody; ITGA4 antibody; MGC90518 antibody; OTTHUMP00000205320 antibody; Very late activation protein 4 receptor, alpha 4 subunit antibody; VLA 4 subunit alpha antibody; VLA-4 subunit alpha antibody; VLA4 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Integrin alpha-4 protein (376-558AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1.
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基因功能參考文獻：
- defines molecularly distinct subsets of articular cartilage that are enriched for osteochondral proteins PMID: 30194383
- study suggests a novel association of ITGA4 +3061A/G polymorphism with AD and its possible contribution to the disease pathology. PMID: 29769839
- The results of this study demonstrated that aggregation of hWJSCs into spherules alters their expression of ITGA4 and ITGA5. PMID: 29411210
- human ADAM11, ADAM23, and ADAM29 selectively support integrin alpha4-dependent cell adhesion. PMID: 28913673
- Recombinant human IL33 inhibited trophoblast invasion and adhesion, and decreased adhesion and invasionassociated molecules such as integrin alpha4beta1 and CD62L. PMID: 28765940
- study analyzes for the first time the expressions of epithelial-mesenchymal transition marker proteins - periostin, integrin alpha4, fibronectin - in metastatic castration-resistant prostate cancer PMID: 28836852
- ITGalpha4beta1 and TLR4 have roles in inducing fibrotic gene expression in response to fibronectin's EDA domain PMID: 28842322
- ITGA4 and PLCG1 are regulated by miR-30b in coronary artery endothelial cells from coronary atherosclerosis clinical samples. PMID: 27464494
- Low CD49D expression is associated with chronic lymphocytic leukaemia in comparison to small lymphocytic lymphoma. PMID: 29153094
- alpha-Integrin expression and function modulates presentation of cell surface calreticulin. PMID: 27310876
- AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD. PMID: 27543429
- sPLA2-IIA activates Integrin alphaVbeta3 and Integrin alpha4beta1 in an allosteric manner. (Review) PMID: 27864802
- Our results suggest that the analysis of alpha4beta7 integrin expression on circulating lymphocytes cannot be considered a reliable test for gastrointestinal involvement in CVID patients PMID: 28323147
- Glycosylation of V1V2 domain of HIV envelope protein determined its binding to alpha4ss7 integrin. PMID: 28577856
- confirmed CD49d as an independent negative OS prognosticator in CLL also in comprehensive models comprising the novel recurrent mutations. PMID: 27109509
- In colon cancer samples, there was a positive correlation between the expression of integrin alpha4 and VEGF-C. Integrin alpha4 and VEGF-C were significantly associated with the clinicopathological parameters (LMVD, Duke's stage, and lymph node metastasis). patients with high integrin alpha4 or VEGF-C expression had significantly shorter overall survival and tumor-free survival time. PMID: 26917449
- Macrophage tissue factor prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking. PMID: 28495929
- gut-homing alpha4beta7 CD4(+) T cells and their functional subsets were profoundly depleted during acute HIV-1 infection. PMID: 26277899
- CD49d determination may be a useful tool to closely monitor Multiple Sclerosis activity in patients who interrupt Natalizumab PMID: 27496090
- Data show tht Rho kinase (ROCK) activity was increased by inhibiting integrin alpha4 with human umbilical vein endothelial cells (HUVECs) and hypoxia. PMID: 26448639
- These data showed that Mycobacterium tuberculosis ESAT-6 and ESAT-6/CFP-10 fusion proteins could induce adhesion of macrophages to fibronectin through alpha4beta1 integrin. PMID: 25081983
- This review gives an up to date insight into the multiple functional role of VLA-4 in cancer and introduces this integrin as a promising target worthwhile to attract attention in biomedical cancer research. PMID: 25564456
- Enhanced susceptibility of activated endocervical CD4+ T cells to HIV may be related to increased CCR5 expression by these cell subsets, but did not appear to be due to direct interaction of integrins a4b7 or a4b1 with HIV envelope. PMID: 25872482
- knockdown of PTTG1 increased expression of integrin alpha 4 (ITGA4), ITGA5, and integrin beta 1 (ITGB1); otherwise, RhoA expression was significantly decreased PMID: 26900962
- ITGA4 expression enhances metastasis in MYCN low neuroblastoma. PMID: 25973900
- Data show that a small molecule inhibitor of the MYC transcription factor can be an effective anticancer agent when delivered using a integrin alphavbeta3 and VLA-4-targeted nanotherapy approach. PMID: 25824336
- Collectively, these data suggest a role for alpha4beta7 integrin in HIV infection that is influenced by both viral and host factors including the sequence of the HIV gp120 alpha4beta7 binding motif, the cytokine milieu and bacterial vaginosis in the genital tract. PMID: 26105197
- Glioma cells induced the migration of BMSCs by promoting the expression of integrin a4. PMID: 26034878
- CD49d and CD26 have independent prognostic value and we suggest its use as a part of routine panel for prognostic stratification of CLL. PMID: 26142332
- Hypermethylation of ITGA4 promoter is increased in inflamed colon tissue. PMID: 25902909
- Regulatory CD4 T cells (Treg) cells in co-infected patients present phenotypic alterations and might have dysfunction marked by low expression of Foxp3 and increased expression of molecules not frequently seen on Treg cells, such as CD49d. PMID: 26329520
- High VLA-4 expression was independently associated with a high probability of complete remission in acute myeloid leukemia patients. PMID: 26155911
- Results show that integrin activation is absolutely required for OPN binding to the alpha4 integrin suggesting that OPN has very low affinity for the alpha4 integrin on human leukocytes under physiological conditions. PMID: 25446551
- alpha4beta7 serves as an attachment factor for some HIV-1 strains. PMID: 25527342
- Selective inhibition of VLA-4 expression on B cells impedes central nervous system accumulation of B cells and reduces susceptibility to experimental autoimmune encephalomyelitis. PMID: 25712734
- The carbon monoxide signaling pathway can rapidly down-modulate binding of the VLA-4 -specific ligand. PMID: 25367365
- CXCR4 and CD49d are important modulators of prognosis in chronic lymphocytic leukemia patients. PMID: 25349153
- Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrin alphaVbeta3, integrin alphavbeta1, and integrin alpha4beta1. PMID: 25398877
- LFA-1 and CR4 alpha chain phosphorylation is needed for chemokine-induced cross-talk to VLA-4 PMID: 25278023
- HIV-1 virions and many gp120s lack detectable alpha4beta7 binding activity. PMID: 25008916
- lymphocyte trafficking into the CNS under VLA-4 blockade can occur by using the alternative adhesion molecules, PSGL-1 and MCAM, the latter representing an exclusive pathway for TH17 cells to migrate over the blood-brain barrier PMID: 25135296
- DNA methylation of integrin alpha4 may be a poor prognostic factor which affects undifferentiated histologic change of breast cancer. PMID: 24756760
- Disruption of the hydrophobic contacts induces the active conformation of integrin alpha 4 beta 7. PMID: 24802248
- Pharmacological inhibition of the VLA-4/vascular adhesion molecule-1 axis in experimental stroke was ineffective PMID: 24743435
- Data indicate that CD47 in cis interactions regulate LFA-1 (integrin alphaLbeta2) and VLA-4 (integrin alpha4beta1) integrin affinity, and this process plays a substantial role in the adhesion of T-cells. PMID: 24006483
- VCAM-1/VLA-4-dependent activation of NF-kappaB has a role in mediating chemoresistance in leukemia cells PMID: 24599548
- Two conserved disulfide bonds located at integrin alpha4C589-C594 and beta7C494-C526 activated alpha4beta7. PMID: 23986478
- Only rotavirus specific CD4 T cells expressed intestinal homing receptors alpha4beta7 and CCR9. PMID: 24606696
- Data suggest CD38 (CD38 antigen (p45) protein) and CD49d (alpha4 Integrin; very late antigen-4 alpha) are more than just markers of an aggressive chronic lymphocytic leukemia (CLL) cell type and play functional roles in pathobiology of CLL. [REVIEW] PMID: 24288111
- Expression of the VLA-4-stimulating factor sequence may help to predict melanoma prometastatic risk. PMID: 23938462
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亞細胞定位：Membrane; Single-pass type I membrane protein.
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蛋白家族：Integrin alpha chain family
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數據庫鏈接：
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