ISCA1 Antibody
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中文名稱：ISCA1兔多克隆抗體
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貨號：CSB-PA887126LA01HU
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規(guī)格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA887126LA01HU at dilution of 1:100
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) ISCA1 Polyclonal antibody
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Uniprot No.：
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基因名：ISCA1
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別名：GK004 antibody; HESB-like domain-containing protein 2 antibody; hIscA antibody; Iron sulfur assembly protein IscA antibody; Iron-sulfur assembly protein IscA antibody; Iron-sulfur cluster assembly 1 homolog antibody; Iron-sulfur cluster assembly 1 homolog, mitochondrial antibody; ISCA1 antibody; ISCA1_HUMAN antibody; mitochondrial antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Iron-sulfur cluster assembly 1 homolog, mitochondrial protein (67-122AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產(chǎn)品，ISCA1 Antibody (CSB-PA887126LA01HU)，的標記方式是Non-conjugated。對于ISCA1 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
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基因功能參考文獻：
- the phenotype observed in all affected subjects with the ISCA1 pathogenic variant is similar to that previously described in all four types of multiple mitochondrial dysfunctions syndromes. PMID: 28356563
- The structural plasticity of the dimeric state of the [2Fe-2S] bound form of human GRX5 is the crucial factor that allows an efficient cluster transfer to the partner proteins human ISCA1 and ISCA2 by a specific protein-protein recognition mechanism. PMID: 24733926
- The data presented here show that the Isu1 suppressor mimics the frataxin effects on Nfs1, explaining the bypassing activity. PMID: 24217246
- ISCA1, ISCA2, and IBA57 were depleted by RNA interference. Depleted cells contained massively swollen and enlarged mitochondria that were virtually devoid of cristae membranes, demonstrating the importance of these proteins for mitochondrial biogenesis. PMID: 22323289
- Iron-binding activity of human iron-sulfur cluster assembly protein hIscA1 PMID: 20302570
- screening a human brain cDNA expression library with serum from a patient suffering from the autoimmune Sjogren's syndrome yielded a gene product called hIscA implicated in iron-sulfur cluster biogenesis PMID: 15262227
- Required for functional heme biosynthesis in erythroid cells. PMID: 19656490
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相關(guān)疾病：Multiple mitochondrial dysfunctions syndrome 5 (MMDS5)
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亞細胞定位：Mitochondrion.
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蛋白家族：HesB/IscA family
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組織特異性：Detected in cerebellum, kidney and heart.
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數(shù)據(jù)庫鏈接：
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