IRF2BP2 Antibody
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中文名稱：IRF2BP2兔多克隆抗體
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貨號(hào)：CSB-PA011817GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：IRF2BP2
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別名：I2BP2_HUMAN antibody; Interferon regulatory factor 2 binding protein 2 antibody; Interferon regulatory factor 2-binding protein 2 antibody; IRF-2-binding protein 2 antibody; IRF-2BP2 antibody; IRF2 binding protein 2 antibody; IRF2BP2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Human IRF2BP2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles. Plays a role in immature B-cell differentiation.
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基因功能參考文獻(xiàn)：
- In the Title. PMID: 27872498
- A novel IRFBP2 mutation was identified in a family with autosomal dominant CVID. Transduction experiments suggest that the mutant protein has an effect on B-cell differentiation and is likely a monogenic cause of the family's CVID phenotype. PMID: 27016798
- ETO2 and IRF2BP2 interacting with the NCOR1/SMRT co-repressor complex, suppresses the expression of erythroid genes until erythroid differentiation. PMID: 26593974
- A deletion variant that lowers IRF2BP2 expression predisposes to coronary artery disease in humans. PMID: 26195219
- analysis of an IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma PMID: 23185413
- Nuclear localization of IRF2BP2 depends on phosphorylation near a conserved NLS. Changes in phosphorylation status likely control nucleocytoplasmic localization of IRF2BP2 during muscle differentiation. PMID: 21887377
- results indicate that DIF-1 plays a key role in breast cancer cell survival PMID: 19190336
- Data demonstrate that IRF-2BP2 is a negative regulator of the NFAT1 transcription factor and suggest that NFAT1 repression occurs at the transcriptional level. PMID: 21576369
- IRF2BP2 is a novel ischemia-induced coactivator of VEGFA expression that may contribute to revascularization of ischemic cardiac and skeletal muscles. PMID: 20702774
- IRF2BP2 works with TEAD transcription factors to upregulate the expression of VEGFA in skeletal and cardiac muscle. IRF2BP2 protein levels are increased in response to tissue ischemia. PMID: 20702774
- Identification of IRF-2 binding protein 1 and IRF-2 binding protein 2 as co-repressor molecules for interferon regulatory factor-2. PMID: 12799427
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亞細(xì)胞定位：Cytoplasm. Nucleus.
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蛋白家族：IRF2BP family
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數(shù)據(jù)庫(kù)鏈接：
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