IRAK3 Antibody

說明書

中文名稱：

IRAK3兔多克隆抗體
貨號：

CSB-PA978564
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA978564(IRAK3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA978564(IRAK3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q9Y616
基因名：

IRAK3
別名：

ASRT5 antibody; IL 1 receptor associated kinase M antibody; IL-1 receptor-associated kinase M antibody; IL1 receptor associated kinase M antibody; Interleukin 1 receptor associated kinase 3 antibody; Interleukin 1 receptor associated kinase M antibody; Interleukin-1 receptor-associated kinase 3 antibody; IRAK M antibody; IRAK-3 antibody; IRAK-M antibody; Irak3 antibody; IRAK3_HUMAN antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Fusion protein of Human IRAK3
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells.
基因功能參考文獻：
1. Clinical trial with house dust mite allergen challenge of asthmatic patients reveal that IRAK-M is a PIN1 target critical for IL-33 signaling in allergic asthma. NMR analysis and docking simulations suggest that PIN1 might regulate IRAK-M conformation and function in IL-33 signaling. PMID: 29686383
2. Rs11541076 in IRAK3, a negative regulator of TLR signalling, as a predictor of anti-TNF treatment response. PMID: 27698401
3. MERS-CoV S protein binds to DPP4 to suppress macrophage activation via induction of IRAK-M, PPARgamma and the immunosuppressive cytokine IL-10. PMID: 28118607
4. Data indicate a strong positive correlation between interleukin-1 receptor-associated kinase 3 (IRAK-M) and pSTAT3 protein in colorectal cancer (CRC). PMID: 27150039
5. IRAK-M functions to modulate inflammatory signaling pathways and is critical in maintaining immune system homeostasis in the gut. However, increased IRAK-M is associated with increased disease pathogenesis and increased cancer severity in human patients. PMID: 27939424
6. Alpha-Melanocyte-Stimulating Hormone Suppresses TLR2-Mediated Functional Responses through IRAK-M in Normal Human Keratinocytes PMID: 26309029
7. IRAK3 methylation was associated with tumor stage and poor prognosis of hepatocellular carcinoma patients. PMID: 25852282
8. The structure function of the death domain of human IRAK-M PMID: 25481771
9. HIF1alpha is a regulator of monocyte functional re-programming in sepsis via regulating IRAKM expression. PMID: 25746953
10. IRAK-M expression is upregulated in peripheral blood cells from idiopathic pulmonary fibrosis patients PMID: 25595781
11. our study demonstrates that patients carrying IRAK-M+22148 G haplotype are more susceptible to sepsis than patients carrying IRAK-M+22148 A haplotype, suggesting that IRAK-M+22148 G haplotype might be a risk factor for sepsis. PMID: 23588345
12. These data indicate the enhancing effect of IRAK-M on epithelial human rhinovirus-16 infection, which is partly through the autophagic pathway. PMID: 24074582
13. IRAK-M mediates TLR7-induced MEKK3-dependent second wave NFjB activation to produce inhibitory molecules PMID: 23376919
14. the tested variations of IRAK-M and SIGIRR genes do not confer a relevant role in the susceptibility to systemic lupus erythematosus in European-descent populations PMID: 22634523
15. these data identify an important signaling regulator in human macrophages that is used by surfactant to control the long-term alveolar inflammatory response, i.e., enhanced IRAK-M activity. PMID: 22886503
16. these data indicate that epithelial IRAK-M overexpression in T(H)2 cytokine-exposed airways inhibits TLR2 signaling, providing a novel mechanism for the increased susceptibility of infections in asthmatic patients. PMID: 22154382
17. Data suggest further evaluation of IRAK3 as a diagnostic and prognostic marker, and as a target for intervention. PMID: 22272346
18. The results confirm the importance of the IRAK3 in asthma pathogenesis in the European populations PMID: 22070913
19. The upregulation of IRAK-M in macrophages is involved in the local immunosuppression around implants, and may contribute to septic and aseptic implant loosening. PMID: 21987497
20. Common SNPs in the IRAK3 gene may be determinants of sepsis-induced acute lung injury. PMID: 21297081
21. Data demonstrates that TGF-beta-dependent induction of IRAK-M expression is an important, clinically relevant mechanism by which tumors may circumvent anti-tumor responses of macrophages. PMID: 21278795
22. Intact IRAK-M is strongly expressed in resting human alveolar macrophages but is cleaved in patients with pneumonia via neutrophil-mediated induction of caspase-6 (CASP-6) activity. PMID: 21098228
23. Identification and characterization of murine IRAK-M PMID: 12054681
24. Thus, our data indicate that IRAK-M could play a pivotal role in the process of endotoxin tolerance in human monocytes and provide evidence that PI3K is involved in regulating its expression. PMID: 14592437
25. IRAK-M is rapidly upregulated in human monocytes pre-exposed to tumor cells and could be involved in deactivation of tumor-infiltrating monocytes mediated by tumor cells. PMID: 15728517
26. These findings indicate that IRAK-M selectively attenuates p38 activation and inhibits innate immunity through stabilizing MKP-1. PMID: 17379480
27. IRAK-M is involved in the pathogenesis of early-onset persistent asthma. PMID: 17503328
28. no evidence to suggest association between inflammatory bowel disease, Crohn's disease (CD), ulcerative colitis (UC) or subsets of CD & UC and IRAK-M; an interaction was found between IRAK-M and CARD15 in UC patients PMID: 17558906
29. LPS tolerance in human endotoxemia models is associated with IRAK-M up-regulation. PMID: 17982103
30. Porphyromonas gingivalis lipopolysaccharide upregulates IRAK-M in macrophages. PMID: 18156187
31. observed striking up-regulation of IRAK-M in monocytes, but without concomitant proinflammatory cytokine production PMID: 18354163
32. Analysis of single single nucleotide polymorphisms and haplotypes did not reveal a significant association between polymorphisms in the IRAK-M gene and atopic dermatitis in this cohort. PMID: 19013233
33. Immunosuppression in sepsis caused by B. pseudomallei is associated with an upregulation of IRAK-M and an indicator of poor outcome. PMID: 19114913
34. IRAK-M is a major mediator of globular adiponectin-induced endotoxin tolerance in primary macrophages PMID: 19414798
35. Nine SNPs distributed across eight genetic regions (ALOX5, IRAK3, ITGB2, NCF2, NFKB1, SELP, SOD1, and STAT1) were associated with risk of glioma with P value of <0.01. PMID: 19423540
36. inhibition of LPS-induced NFKB and ERK activation by acute alcohol leads to hyporesponsiveness of monocytes to LPS due to increased IRAK-M; chronic alcohol sensitizes monocytes to LPS through decreased IRAK-M expression and activation of NFKB and ERK PMID: 19561104
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相關(guān)疾病：

Asthma-related traits 5 (ASRT5)
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

Protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily
組織特異性：

Expressed in eosinophils, dendritic cells and/or monocytes (at protein level). Expressed predominantly in peripheral blood lymphocytes.
數(shù)據(jù)庫鏈接：

HGNC: 17020

OMIM: 604459

KEGG: hsa:11213

STRING: 9606.ENSP00000261233

UniGene: Hs.369265

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