ING1 Antibody
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中文名稱：ING1兔多克隆抗體
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貨號：CSB-PA011712GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：ING1
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別名：2610028J21Rik antibody; AA407184 antibody; AI875420 antibody; Growth inhibitor ING 1 antibody; Growth inhibitor ING1 antibody; Growth inhibitory protein ING 1 antibody; Growth inhibitory protein ING1 antibody; Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds antibody; ING 1 antibody; Ing1 antibody; ING1_HUMAN antibody; Inhibitor of growth 1 antibody; Inhibitor of growth family member 1 antibody; Inhibitor of growth protein 1 antibody; mING1h antibody; OTTHUMP00000018703 antibody; OTTHUMP00000018704 antibody; OTTHUMP00000018705 antibody; OTTHUMP00000018706 antibody; p24ING1c antibody; p33 antibody; p33 ING1 antibody; p33ING1 antibody; p33ING1b antibody; p33ING1c antibody; p37Ing1b antibody; p47 antibody; p47ING1a antibody; Tumor suppressor ING 1 antibody; Tumor suppressor ING1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Human ING1-specific
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
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基因功能參考文獻：
- The p37 controls cortical NuMA levels via the phosphatase PP1 and its regulatory subunit Repo-Man, but it acts independently of Galphai, the kinase Aurora A, and the phosphatase PP2A. PMID: 29222185
- Nuclear entrapment of p33ING1b by inhibition of exportin-1 triggers apoptosis in head and neck squamous cell cancer cells. PMID: 29729696
- Results from a study on gene expression variability markers in early-stage human embryos shows that ING1 is a putative marker for the 3-day, 8-cell embryo stage. PMID: 26288249
- Our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration. PMID: 27305909
- ING1 regulates the nucleolar epigenome and rDNA transcription suggesting that regulation of protein synthesis might serve as the basis for ING1 function as a type II tumor suppressor. PMID: 27903908
- a novel corepressor function of ING1b on various AR functions, thereby inhibiting prostate cancer cell growth. PMID: 26993046
- ING1a acts as a novel link in the activation of the Rb pathway that can impose senescence in the absence of activating p53-mediated DNA damage signaling, and should prove useful in defining the molecular events contributing to Rb-induced senescence. PMID: 26439691
- These data indicate that stromal ING1 expression can predict the survival of patients with luminal breast cancer PMID: 26306560
- Overexpression of let-7b in gastric cancer can inhibit invasion and migration of gastric cancer cells through directly targeting the tumor metastasis-associated gene ING1. PMID: 25613480
- Results show that ING1 expression is under-regulated in pancreatic duct adenocarcinoma (PDAC) and is a direct target of miR-371-5p involved in miR-371-5p inducing promotion of PDAC cells proliferation. PMID: 25411783
- ING1b sumoylation regulates the binding of ING1b to the ISG15 and DGCR8 promoters, consequently regulating ISG15 and DGCR8 transcription. PMID: 24903338
- Our results identify a novel functional relationship between cytoplasmic p33ING1b and oral squamous cell carcinoma patient survival PMID: 24912621
- Ing1b lacking cells showed decreased ability to repair the oxidized DNA. PMID: 24242916
- ING1 translocates to the mitochondria of primary fibroblasts and established epithelial cell lines in response to apoptosis inducing stimuli, independent of the cellular p53 status. PMID: 24008732
- ING1 acts at early stages of the DNA damage response activating a variety of repair mechanisms. PMID: 23459830
- Src may play a major role in regulating ING1 levels during tumorigenesis in those cancers in which high levels of Src expression or activity are present. PMID: 23585863
- Data identify a pathway by which ING1a induces senescence and indicate that altered endocytosis activates the Rb pathway, subsequently effecting a senescent phenotype. PMID: 23472054
- ING1b epigenetically regulates several miRNAs including miR-203. PMID: 23462723
- the reduced expression of p33(ING1b) in gastric adenocarcinoma tissues and gastric adenocarcinoma cell lines PMID: 22237655
- inhibitor of growth protein 1 (Ing1) is required for targeting active DNA demethylation PMID: 23388825
- ING1 gene mutations are rare in laryngeal squamous cell carcinoma. PMID: 22260079
- Data suggest that the combined detection of p33ING1, p53, and Beclin1 genes and proteins will be helpful for early diagnosis and prognosis judgment for NSCLC, and can provide experimental evidence for biotherapy of NSCLC. PMID: 21779982
- Data show that overexpression of p33(ING1b) induces cellular senescence and upregulates p16(INK4a) expression in fibroblasts. PMID: 21896275
- ING1 stabilizes p53 by inhibiting polyubiquitination of multimonoubiquitinated forms via interaction with and colocalization of the HAUSP-deubiquitinase with p53. PMID: 21731648
- AZT upregulates the expression of p33ING1b, a possible mechanism in regulating senescence and apoptosis of TJ905 cells. PMID: 21176536
- Data show that ectopic expression of miR-622 promoted invasion, tumorigenesis and metastasis of gastric cancer cells, and that ING1 is a direct target of miR-622. PMID: 21528065
- p33ING1 triggers a senescent phenotype in cultured primary fibroblasts in a p53-dependent fashion. PMID: 21078114
- relocation of p33ING1b from the nucleus to the cytoplasm, where the protein is tethered by 14-3-3eta, participates in tumorigenesis and progression in HNSCC PMID: 21432775
- Loss of ING1 is associated with non-small cell lung cancer. PMID: 21286670
- ING1 proteins regulate the expression of proteins that are critical for angiogenesis in glioblastoma multiforme (GBM) such as the angiopoietins. PMID: 20066899
- ING1 in normal and neoplastic tissues. PMID: 11991811
- PBLs from pts with haematological malignancies and controls expressed mainly the p33/ING1 transcript, with low levels of p24/ING1 and p33/ING1 mRNA were found. Genetic changes in p33/ING1 play no role in these malignancies. PMID: 12008079
- role in differential regulation of histone acetylation PMID: 12015309
- Data suggest that p33(ING1) cooperates with p53 in UVB-induced apoptosis via the mitochondrial cell death pathway in melanoma cells. PMID: 12243754
- overexpression and mutation of the ING1 gene are infrequent in human basal cell carcinoma PMID: 12632089
- ING1 expression is frequently associated with adenocarcinoma of the esophagogastric junction tumorigenesis, further supporting its role as a tumor suppressor gene, and ING1 expression is independent of p53 status PMID: 12637159
- ING1b gene expression plays an important role in carcinogenesis of non-small cell lung cancer PMID: 14581367
- Deregulated expression and mislocalization of ING1 proteins are common events in gliomas and glioblastomas PMID: 14676120
- ING1 mutations abrogate its enhancement in nucleotide excision repair in melanoma. PMID: 15201991
- Decreased expression of the candidate tumor suppressor gene ING1 is associated with advanced neuroblastomas PMID: 15375504
- ING tumor suppressors are involved in signalling pathways [review] PMID: 15526165
- Mutation and loss of expression are not the main reasons for the disfunction of p33(ING1b) in pancreatic carcinoma PMID: 15534913
- p33ING1 expression induces features of cellular senescence through two silencing domains and interaction with Ras PMID: 15601862
- p33ING1b enhances taxol-induced apoptosis through p53-dependent pathway in human osteosarcoma cells; p33ING1b may be an important marker and/or therapeutic target in the prevention and treatment of osteosarcoma PMID: 15662138
- Down regulation of p33ING1b is associated with the pathogenesis of ovarian cancers PMID: 15677627
- Loss or inactivation of p33(ING1b) normal function may be an important mechanism for the development of hepatocellular carcinoma retaining wild-type p53. PMID: 15800978
- p33(ING1b) and p47(ING1a) mRNA expressions are closely related with the carcinogenesis and progression of human sporadic colorectal cancer PMID: 16273637
- p33ING1b prominently enhances etoposide-induced apoptosis through p53-dependent pathways in human osteosarcoma cells. PMID: 16325212
- ING1 expression was up-regulated in all 7 lung cancer cell lines that had a p53 mutation. PMID: 16465410
- Subcellular targeting of ING1 by phosphorylation-dependent 14-3-3 binding regulates P21 expression. PMID: 16581770
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相關疾病：Squamous cell carcinoma of the head and neck (HNSCC)
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亞細胞定位：Nucleus.
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蛋白家族：ING family
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組織特異性：Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and c
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