INF2 Antibody
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中文名稱：INF2兔多克隆抗體
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貨號(hào)：CSB-PA637740LA01HU
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規(guī)格：￥440
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圖片：
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IHC image of CSB-PA637740LA01HU diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. -
IHC image of CSB-PA637740LA01HU diluted at 1:400 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) INF2 Polyclonal antibody
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Uniprot No.：
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基因名：INF2
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別名：C14orf151 antibody; C14orf173 antibody; CMTDIE antibody; DKFZp762A0214 antibody; FLJ22056 antibody; FSGS5 antibody; HBEAG binding protein 2 binding protein C antibody; HBEBP2 binding protein C antibody; HBEBP2-binding protein C antibody; INF 2 antibody; inf2 antibody; INF2_HUMAN antibody; Inverted formin 2 antibody; Inverted formin FH2 and WH2 domain containing antibody; Inverted formin-2 antibody; MGC13251 antibody; pp9484 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Inverted formin-2 protein (926-1047AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
本頁面中的產(chǎn)品，INF2 Antibody (CSB-PA637740LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于INF2 Antibody，我們還提供其他標(biāo)記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:200-1:500 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Severs actin filaments and accelerates their polymerization and depolymerization.
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基因功能參考文獻(xiàn)：
- INF2-mediated actin polymerization on the endoplasmic reticulum stimulates mitochondrial division by two independent mechanisms: (1) mitochondrial calcium uptake, leading to inner mitochondrial membrane constriction; and (2) Drp1 oligomerization, leading to outer mitochondrial membrane constriction. PMID: 29142021
- Studies indicate that INF2, a formin, that is mutated in hereditary renal and neurodegenerative disorders. PMID: 29947928
- Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2. PMID: 26764407
- hese findings reveal novel molecular events underlying the regulation of INF2 function and localization, and provided insights in understanding the relationship between SPOP mutations and dysregulation of mitochondrial dynamics in prostate cancer. PMID: 28448495
- All individuals with INF2 mutations presenting with a thrombotic microangiopathy also had atypical hemolytic uremic syndrome risk haplotypes, potentially accounting for the genetic pleiotropy PMID: 27974406
- Propose that examination of INF2 expression may help to differentiate minimal change disease from focal segmental glomerulosclerosis and evaluate the clinical severity of steroid resistance nephrotic syndrome in children. PMID: 26383224
- FHOD1 and INF2 are novel regulators of inter- and intra-structural contractility of podosomes. PMID: 26621033
- Report novel mutations in the inverted formin 2 gene of Chinese families contributing to focal segmental glomerulosclerosis. PMID: 26039629
- Assembly and turnover of short actin filaments by the formin INF2 and profilin. PMID: 26124273
- INF2 mutations are associated with focal segmental glomerulosclerosis. PMID: 25165188
- this study identifed three novel mutations of INF likely efect hereditary neuropathy with glomerulopathy. PMID: 24174593
- actin monomer binding to the DAD of INF2 competes with the DID/DAD interaction, thereby activating actin polymerization PMID: 23921379
- INF2 mutation was detected both father and his son PMID: 23847988
- This study showed that INF2 mutations in Charcot-Marie-Tooth disease complicated with focal segmental glomerulosclerosis. PMID: 23521651
- In podocytes, INF2 appears to be an important modulator of actin-dependent behaviors that are under the control of Rho/mDia signaling. PMID: 23620398
- INF2 mutations were found in 2 of 281 individuals with sporadicfocal and segmental glomerulosclerosis PMID: 23014460
- Our study confirms the link between INF2 mutations and Charcot-Marie-Tooth-associated glomerulopathy and widens the spectrum of pathogenic mutations. PMID: 22961558
- A novel mutation, outside of the candidate region for diagnosis, in the inverted formin 2 gene can cause focal segmental glomerulosclerosis. PMID: 22971997
- Formation of stabilized, detyrosinated microtubules required the formin INF2. PMID: 22986496
- study found actin polymerization through ER-localized INF2 was required for efficient mitochondrial fission; INF2-induced actin filaments may drive initial mitochondrial constriction, which allows Drp1-driven secondary constriction PMID: 23349293
- Mutations to the formin homology 2 domain of INF2 protein have unexpected effects on actin polymerization and severing. PMID: 22879592
- Splice variant-specific cellular function of the formin INF2 in maintenance of Golgi architecture. PMID: 21998196
- INF2 mutations were responsible for 16% of all cases of autosomal dominant focal and segmental glomerulosclerosis, with these mutations clustered in exon 4. PMID: 21866090
- Actin monomers inhibit microtubule binding/bundling by INF2 PMID: 21998204
- INF2 mutations appear to cause many cases of FSGS-associated Charcot-Marie-Tooth neuropathy, showing that INF2 is involved in a disease affecting both the kidney glomerulus and the peripheral nervous system. PMID: 22187985
- The effects of disease-causing INF2 mutations suggest an important role for this protein and its interaction with other formins in modulating glomerular podocyte phenotype and function. PMID: 21278336
- In conclusion, we described an additional familial case of the autosomal dominant form of focalsegmental glomerulosclerosis associated with INF2 mutations. PMID: 20803156
- Six of the seven distinct altered residues localized to an INF2 region that corresponded to a subdomain of the mDia1 diaphanous inhibitory domain reported to co-immunoprecipitate with IQ motif-containing GTPase-activating protein 1 PMID: 21258034
- Study identified nine independent nonconservative missense mutations in INF2, which encodes a member of the formin family of actin-regulating proteins. PMID: 20023659
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相關(guān)疾病：Focal segmental glomerulosclerosis 5 (FSGS5); Charcot-Marie-Tooth disease, dominant, intermediate type, E (CMTDIE)
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亞細(xì)胞定位：Cytoplasm, perinuclear region.
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蛋白家族：Formin homology family
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組織特異性：Widely expressed. In the kidney, expression is apparent in podocytes and some tubule cells.
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數(shù)據(jù)庫鏈接：
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