IMPDH1 Antibody

中文名稱：

IMPDH1兔多克隆抗體
貨號：

CSB-PA22459A0Rb
規格：

￥440
圖片：
IHC image of CSB-PA22459A0Rb diluted at 1:600 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA22459A0Rb diluted at 1:600 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of Hela cells with CSB-PA22459A0Rb at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) IMPDH1 Polyclonal antibody
Uniprot No.：

P20839
基因名：

IMPDH1
別名：

IMDH1_HUMAN antibody; IMP (inosine monophosphate) dehydrogenase 1 antibody; IMP dehydrogenase 1 antibody; IMPD 1 antibody; IMPD antibody; IMPD1 antibody; IMPDH 1 antibody; IMPDH I antibody; IMPDH-I antibody; Impdh1 antibody; Inosine 5' monophosphate dehydrogenase 1 antibody; Inosine monophosphate dehydrogenase 1 antibody; Inosine-5''-monophosphate dehydrogenase 1 antibody; LCA11 antibody; RP10 antibody; sWSS2608 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Inosine-5\'-monophosphate dehydrogenase 1 protein (191-281AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，IMPDH1 Antibody (CSB-PA22459A0Rb)，的標記方式是Non-conjugated。對于IMPDH1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA22459B0Rb	IMPDH1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA22459C0Rb	IMPDH1 Antibody, FITC conjugated
Biotin	CSB-PA22459D0Rb	IMPDH1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000
IF	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
基因功能參考文獻：
1. We have found that the rs2278294 G allele exerts statistically significant inhibition on post-kidney transplant body mass index gain PMID: 30056902
2. In our cohort of >300 familial cases of autosomal-recessive retinitis pigmentosa, PKRP004 is the only family harboring a mutation in IMPDH1. PMID: 25439607
3. Expression of IMPDH mRNA after mycophenolate administration in male volunteers. PMID: 25105143
4. A novel mutation, p.L270R in IMPDH1, was found to be retinitis pigmentosa-causing in one family. PMID: 23534816
5. p53 has a novel function in regulating purine biosynthesis, aided by miR-34a-dependent IMPDH repression. PMID: 22301190
6. IMPDH has a function in the retina, apparently independent of its enzymatic activity, mediated by retina-specific variants. PMID: 22183375
7. IMPDH1 mutation is associated with retinitis pigmentosa. PMID: 21791244
8. The mutation frequency of IMPDH1 gene of the Han population in Ganzhou city was similar as approximately 2-5% of the autosomal dominant retinitis pigmentosa cases among Americans of European origin and Europeans. PMID: 20238028
9. resequenced IMPDH1 and IMPDH2 using DNA from 288 individuals from three ethnic groups and performed functional genomic studies of the sequence variants observed; identified 73 single nucleotide polymorphisms in IMPDH1, 59 novel PMID: 20718729
10. Potential associations between the most frequent single nucleotide polymorphisms in both IMPDH genes and clinical outcome in renal transplant recipients. PMID: 20679962
11. Inosine 5'-monophosphate dehydrogenase 1 haplotypes have a role in mycophenolate mofetil gastrointestinal intolerance in pediatric heart transplant patients PMID: 20649757
12. The risk of subclinical acute rejection for recipients who cannot adapt in therapeutic drug monitoring of mycophenolic acid seems to be influenced by IMPDH1 rs2278293 polymorphism. PMID: 20136638
13. In this small sample of pediatric heart transplant patients receiving MMF, ABCC2, IMPDH1 and IMPDH2 SNPs were associated with MMF GI intolerance and bone marrow toxicity. PMID: 20061166
14. This mutant isoenzyme maps to human chromosome region 7q and has an amino acid substitution (arginine for proline). It is involved in the etiology of autosomal dominant retinitis pigmentosa in humans. PMID: 11875049
15. A missense mutation in this isozyme causes human autosomal retinitis pigmentosa. PMID: 11875050
16. A novel IMPDH1 gene mutation (Arg231Pro) was associated with a severe form of autosomal dominant retinitis pigmentosa. PMID: 15465556
17. The most commonly reported Asp226Asn mutation was not found in the Japanese population, instead two novel mutations were found. These findings suggest that mutations of the IMPDH1 gene cause ADRP (autosomal dominant retinitis pigmentosa). PMID: 16038673
18. Asp226Asn mutation is associated with a severe, early-onset form of retinal degeneration in members of this family. PMID: 16214101
19. In this family with a mutation in IMPDH1, we found a specific phenotype with rod function affected more than cone function, foveal edema, and central retinal function preserved for a long period of time. PMID: 16272056
20. Mutations in IMPDH1 account for approximately 2% of families with adRP, and de novo IMPDH1 mutations are also rare causes of isolated LCA (Leber congenital amaurosis). PMID: 16384941
21. Identification of unique retinal isoforms supports the existence of a novel IMPDH1 function in the retina, one that is probably altered by disease-causing mutations. PMID: 16936083
22. If IMPDH genetic variability contributes to azathioprine resistance in inflammatory bowel disease it does so infrequently. PMID: 17001353
23. Mycophenolate mofetil up-regulates IMPDH-I and IMPDH-II mRNA in peripheral blood mononuclear cells. May predict acute rejection. PMID: 17713475
24. C-terminal extension unique to the retinal isoforms blocks the nucleic acid binding site of IMPDH1, and thus uniquely regulates protein function within photoreceptors. PMID: 18295591
25. RHO, PRPF31, RP1, and IMPDH1 were screened and causative mutations were identifiedin 4% of isolated and 2% of autosomal dominant forms of retinitis pigmentosa patients from India. PMID: 18552984
26. IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA PMID: 18974094
顯示更多

收起更多
相關疾病：

Retinitis pigmentosa 10 (RP10); Leber congenital amaurosis 11 (LCA11)
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

IMPDH/GMPR family
組織特異性：

IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
數據庫鏈接：

HGNC: 6052

OMIM: 146690

KEGG: hsa:3614

STRING: 9606.ENSP00000345096

UniGene: Hs.654401

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human