IL17B Antibody

說明書

中文名稱：

IL17B兔多克隆抗體
貨號：

CSB-PA648539
規(guī)格：

￥1090
圖片：
Immunohistochemical analysis of paraffin-embedded human-small-intestine, antibody was diluted at 1:200
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q9UHF5
基因名：

IL17B
別名：

Cytokine like protein Zcyto7 antibody; Cytokine Zcyto7 antibody; IL 17B antibody; IL 20 antibody; IL-17B antibody; IL-20 antibody; IL17B antibody; IL17B_HUMAN antibody; IL20 antibody; Interleukin 17 beta antibody; Interleukin 17B antibody; Interleukin 20 antibody; Interleukin-17B antibody; Interleukin-20 antibody; MGC138900 antibody; MGC138901 antibody; Neuronal interleukin 17 related factor antibody; Neuronal interleukin-17-related factor antibody; NIRF antibody; ZCYTO7 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Rat
免疫原：

Synthetic peptide from Human protein at AA range: 1-50
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
純化方式：

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

IHC,ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	IHC-p:1:50-300
ELISA	1:10000-20000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
基因功能參考文獻：
1. The results indicate that the IL-17B/IL-17RB signaling can promote the growth and migration of tumor cells. PMID: 27146881
2. Our data revealed a new mechanism that IL-17B enhanced the progression of gastric cancer by activating mesenchymal stem cells. PMID: 28145881
3. Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B in the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus completely segregated with the phenotype in the studied Keratoconus family PMID: 27703147
4. This comprehensive review details the recognition of activity, signaling, and the roles of IL17B-IL17RB in breast cancer have caused to determination of new therapeutic mechanisms--{REVIEW} PMID: 28160754
5. Studies indicate that interleukin 17 (IL-17B)/interleukin 17 receptor B (IL-17RB) signaling is essential for pancreatic cancer malignancy. PMID: 26285835
6. IL-17B-IL-17RB signaling promotes pancreatic cancer malignancy. PMID: 25732306
7. Results show that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promot tumorigenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells. PMID: 23851503
8. IL-17B can enhance the effects of TNF-alpha on the production of cytokines and chemokines that control immune cell trafficking and neutrophil homeostasis in the inflamed tissues. PMID: 24056520
9. IL-17A, IL-17B, IL-17F and IL-23 in systemic lupus erythematosus patients were examined and the correlation between levels of the investigated cytokines and VEGF, PIGF, as well as number of endothelial cells, was investigated. PMID: 23661335
10. expression and functional study of IL-17B PMID: 22394632
11. IL-17 may play an important role in the occurrence of nasal polyps by overexpression. PMID: 16805377
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亞細胞定位：

Secreted.
蛋白家族：

IL-17 family
組織特異性：

Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.
數(shù)據(jù)庫鏈接：

HGNC: 5982

OMIM: 604627

KEGG: hsa:27190

STRING: 9606.ENSP00000261796

UniGene: Hs.156979

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