IL13RA2 Antibody

說明書

中文名稱：

IL13RA2兔多克隆抗體
貨號：

CSB-PA009597
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q14627
基因名：

IL13RA2
別名：

Cancer/testis antigen 19 antibody; CD213a2 antibody; CT19 antibody; I13R2_HUMAN antibody; IL-13 receptor subunit alpha-2 antibody; IL-13R subunit alpha-2 antibody; IL-13R-alpha-2 antibody; IL-13RA2 antibody; IL13 receptor antibody; IL13BP antibody; IL13R antibody; Il13ra2 antibody; Interleukin 13 binding protein antibody; Interleukin 13 receptor alpha 2 chain antibody; Interleukin-13 receptor subunit alpha-2 antibody; Interleukin-13-binding protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the C-terminal region of Human IL-13Rα2.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).
基因功能參考文獻：
1. this study shows that tricellulin is regulated via interleukin-13-receptor alpha2, affects macromolecule uptake, and is decreased in ulcerative colitis PMID: 28612843
2. IL-13Ralpha2 alone induces invasiveness of human glioblastoma multiforme (GBM) cells without affecting their proliferation. In contrast, in the presence of the mutant EGFR (EGFRvIII), IL-13Ralpha2 promotes GBM cell proliferation in vitro and in vivo. PMID: 29203859
3. The results showed that IL13Ralpha2 may be used as a marker of poorer prognosis in high-grade astrocytomas, even among tumors of the same grade. PMID: 28079349
4. TMEM219 plays a critical role in Chi3l1-induced IL-13Ralpha2 mediated signalling and tissue responses. PMID: 27629921
5. This study shows interleukin-13 receptor alpha 2 expression could be a useful prognostic marker for selecting patients with luminal breast cancer likely to follow a clinically aggressive course despite receiving systemic therapy. PMID: 29911489
6. Transgenic expression of IL15 is an appealing strategy to enhance CAR T-cell effector function. We tested this approach in our IL13Ralpha2-positive glioma model in which limited IL13Ralpha2-CAR T-cell persistence results in recurrence of antigen-positive gliomas. T cells were genetically modified with retroviral vectors encoding IL13Ralpha2-CARs or IL15 (IL13Ralpha2-CAR.IL15 T cells). PMID: 28550091
7. IL-13Ralpha2 may have a role in decreased overall survival in gastric cancer after gastrectomy PMID: 27351230
8. cigarette smoke extracts activate the PKA, CREB, and IL-13Ralpha2 axis in lung endothelial cells. PMID: 27986643
9. High expression of IL-13Ra2 is significantly associated with the growth and metastasis of glioma cells via the Scr/PI3K/Akt/mTOR pathway. PMID: 27623944
10. Data indicate single-chain antibody (scFv47) as a highly selective interleukin 13 receptor subunit alpha 2 (IL13Ralpha2) targeting agent. PMID: 26656559
11. IL13Ralpha2 knockdown and IL-13 treatment cooperatively upregulated the metastasis suppressor tumor protein 63 (TP63) in a STAT6-dependent manner. PMID: 26208975
12. Expression of CXCR3 in fibroblasts is associated with the expression of IL-13Ralpha2. PMID: 25514189
13. In this review, we will discuss the recent advances in the IL13Ralpha2-targeted immunotherapy and evaluate the most promising strategy for targeted GBM immunotherapy. [review] PMID: 25247196
14. Study presents evidence that PNR could promote ERalpha-negative breast cancer metastasis through activation of IL-13Ralpha2-mediated signaling pathway. PMID: 24747967
15. In cytotoxicity assays, CAR T cells killed CAR T cells killed IL13Ra1- and/or IL13Ra2-positive cells in contrast to IL13Ra1- and IL13Ra2-negative controls PMID: 24841514
16. IL13Ralpha2 over-expression is associated with glioma. PMID: 24204956
17. Expression of IL-13Ralpha2 in tumors was significantly decreased with IL-13-PE treatment as compared to the controls and the number of myeloid-derived suppressor cells (MDSC) was also significantly reduced in the spleens of the IL-13-PE treated mice PMID: 23421960
18. high expression of IL-13Ralpha2 was associated with later stages of disease progression and poor outcome in patients with colorectal cancer PMID: 22505647
19. IL-13RALPHA2 is involved in cancer metastasis through activation of ERK/AP-1 PMID: 21858811
20. expression of IL-13Ralpha2 prevents apoptosis and contributes to tumor growth. PMID: 21596889
21. A novel function of histone modification in the regulation of IL-13Ralpha2 in pancreatic cancer cell lines in vitro and in vivo, was identified. PMID: 21477288
22. Cells with high IL-13Ralpha2 expression rapidly and efficiently deplete extracellular IL-13 and could have important implications for the design and characterization of IL-13 antagonists. PMID: 21622864
23. IL-13Ralpha2 may be an important endogenous regulator of IL-13-induced cutaneous inflammation in humans. PMID: 20971924
24. The expression level of IL-13Ralpha2 was significantly reduced in first-recurrent glioblastomas (frGBMs) compared to primary GBMs, and significantly reduced in all untreated malignant astrocytomas compared with treated frGBMs. PMID: 20805641
25. In eosinophil lineage-deficient IL-13 transgenic mice with eosinophilic esophagitis, IL-13-induced remodeling is significantly enhanced by IL-13Ralpha2 deletion, indicating an inhibitory effect of IL-13Ralpha2. PMID: 20543112
26. IL-13Ralpha2-positive tumors were targeted by IL-13PE cytotoxin in vitro and in vivo in an orthotopic murine model of human pancreatic cancer. PMID: 20068108
27. Soluble IL-13R2alpha and membrane IL-13R2alpha isoforms are both derived from the membrane form of the human receptor. An alternatively spliced sIL-13R2alpha transcript is absent in humans, compared with mice. PMID: 20007572
28. IL-13Ralpha(345-354) (WLPFGFILI) induced a CD8(+) T-cell line that specifically produced IFN-gamma in response to HLA-A2+ T2 cells pulsed with the relevant peptide and lysed these cells. PMID: 12231526
29. interleukin-13 receptor possibly plays an important part in the early inflammatory process of psoriasis; however, its function is lost in the psoriatic keratinocytes. PMID: 12445201
30. IL-4/IL-13-induced IL-13Ralpha2 expression is potentiated by TNF-alpha PMID: 12485861
31. The 5' flanking region of IL-13Ra2 has been isolated and cloned and the gene control region functionally characterized. PMID: 12816724
32. The inhibitory effects of the IL-13 receptor alpha 2 subunit on IL-13 signaling are dependent on both the level of expression of the receptor and the concentration of IL-13. PMID: 16751396
33. Immunohistochemical analyses revealed that 83% of ovarian cancer specimens express IL-13Ralpha2, whereas normal ovary samples expressed none or very low levels. PMID: 16902988
34. data suggest that IL13RA2 gene polymorphisms may be involved in susceptibility to systemic sclerosis PMID: 16981293
35. Highly variable expression of IL13Ralpha2 protein both within and across specimens of glioblastoma multiforme. PMID: 17804706
36. IL-13Ralpha2 and Olig2 have been identified and confirmed to be interesting candidate genes whose differential expression likely plays a role in malignant progression of astrocytomas PMID: 17917751
37. RasGRP4 translocates to varied intracellular compartments via its DAG/PMA-binding domain to regulate signaling pathways that control gene and protein expression in MCs, including the cell's ability to respond to IL-13. PMID: 18024961
38. soluble form of IL-13Ralpha(2) may therefore modulate mucus overproduction by IL-13 through the pathway including IL-13Ralpha(1) in normal human bronchial epithelial cells PMID: 18028464
39. IL-13R alpha 2, EphA2, and Fra-1 are attractive therapeutic targets representing molecular denominators of high-grade astrocytomas. One hundred percent of GBM tumors overexpress at least one of these proteins. PMID: 18172271
40. 13Ralpha2 protein and mRNA are expressed to significantly higher levels in brainstem glioma than in normal brain tissue PMID: 18430795
41. The feasibility of MRI to visualize different phases of immune response when IL-13Ralpha2-specific CTLs are administered directly to the glioma tumor bed. PMID: 18559603
42. IL-13Ralpha2 is expressed by both primary bronchial epithelial cells and fibroblasts as an intracellular protein with a diffuse cytoplasmic distribution; in vivo, IL-13Ralpha2 is expressed in the airway mucosa mainly by bronchial epithelial cells PMID: 18564628
43. analysis of cDNA clone and prokaryotic expression of human interleukin-13 receptor [alpha]2 chain PMID: 18677476
44. study concludes that matrix metalloproteinase-8 cleaves IL-13R alpha 2 in vitro and contributes to the solubilization of IL-13R alpha 2 in vivo PMID: 18694590
45. Hepatic stellate cells in sinusoidal lesions of liver from patients with nonalcoholic steatohepatitis express high levels of high-affinity IL-13R (IL-13 receptor alpha2), whereas fatty liver and normal liver specimens do not express IL-13Ralpha2. PMID: 18802068
46. Human adrenomedullin up-regulates interleukin-13 receptor alpha2 chain in prostate cancer in vitro and in vivo. PMID: 19010904
47. Cytokines IL-13Ralpha2, IL-4, IL-6, IL-8 and TNF-alpha may play roles in the pathogenesis of pediatric HSP/HSPN. PMID: 19149920
48. Human and murine neuroendocrine pheochromocytoma overexpress the IL-13Ralpha2 chain, and an IL-13PE-based receptor-directed anticancer approach may prove useful in treatment for metastatic pheochromocytoma patients. PMID: 19491224
49. IL-13Ralpha2 may serve as a prognostic biomarker of invasion and metastasis in pancreatic cancer. PMID: 19887609
50. Humans only express the membrane bound form of the IL-13 receptor alpha 2 PMID: 18307523
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Type I cytokine receptor family, Type 5 subfamily
數據庫鏈接：

HGNC: 5975

OMIM: 300130

KEGG: hsa:3598

STRING: 9606.ENSP00000243213

UniGene: Hs.336046

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