IL11RA Antibody
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中文名稱：IL11RA兔多克隆抗體
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貨號：CSB-PA049750
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規(guī)格：￥1100
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圖片：
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Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: CSB-PA049750(IL11RA Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：CRSDA antibody; hCG_2011440 antibody; I11RA_HUMAN antibody; IL-11 receptor subunit alpha antibody; IL-11R subunit alpha antibody; IL-11R-alpha antibody; IL-11RA antibody; IL11RA antibody; Interleukin 11 receptor alpha antibody; Interleukin 11 receptor alpha chain antibody; Interleukin-11 receptor subunit alpha antibody; MGC2146 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Fusion protein of Human IL11RA
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:5000 WB 1:500-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.; Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.; Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.
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基因功能參考文獻：
- The results presented here reveal an additional function in classic IL-11 signaling, highlighting the importance of the IL-11R stalk in IL-11 signaling PMID: 29523682
- The D2 domain of the IL-11R contains two N-linked glycans, which are dispensable for its biological activity, but differentially control maturation and intracellular trafficking of the receptor. PMID: 29533934
- High IL11RA expression is associated with endometrioid tumours. PMID: 28186993
- Report IL11RA and MELK amplification in gastric cancer cell lines and primary gastric adenocarcinomas. PMID: 27920471
- These results indicate that IL-11Ralpha is a potential target for the development of molecular targeted therapy and noninvasive tumor imaging in human osteosarcoma. PMID: 25524575
- IL11RA promoter polymorphism--rs1061758--may be associated with the risk of papillary thyroid cancer in the Korean population. PMID: 21982075
- data suggest that IL-11Ralpha-CAR T cells may represent a new therapy for patients with osteosarcoma pulmonary metastases PMID: 22075555
- IL11 as well as IL11RA are likely to play a role in the progression of endometrial carcinoma. PMID: 20553623
- IL-11Ralpha was expressed in both epithelial and stromal cells, with epithelial staining being more intense PMID: 12200462
- the interleukin-11 receptor alpha-chain has evidence of antiapoptotic effects in human colonic epithelial cells PMID: 14701802
- IL-11Ralpha is a candidate target for translational clinical trials against advanced and metastatic prostate cancer. PMID: 14744752
- interleukin-11 receptor is expressed in CD38-positive cells from patients with multiple myeloma PMID: 15512823
- High expression of interleukin-11 receptor alpha is associated with Hodgkin's lymphoma PMID: 16291580
- High interleukin 11 receptor is associated with breast cancer PMID: 16614887
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相關(guān)疾病：Craniosynostosis and dental anomalies (CRSDA)
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亞細胞定位：[Interleukin-11 receptor subunit alpha]: Membrane; Single-pass type I membrane protein.; [Soluble interleukin-11 receptor subunit alpha]: Secreted.; [Isoform HCR2]: Secreted.
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蛋白家族：Type I cytokine receptor family, Type 3 subfamily
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組織特異性：Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2. Also expressed in normal and malig
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