ICSA Antibody

^{Rare Species}

說明書

產品詳情

Uniprot No.：

Q7BCK4
基因名：

ICSA
別名：

Outer membrane protein IcsA autotransporter [Cleaved into: Outer membrane protein IcsA; Outer membrane protein IcsA translocator] icsA virG CP0182
反應種屬：

Shigella flexneri
免疫原：

Recombinant Shigella flexneri ICSA protein (311-547aa)
免疫原種屬：

Shigella flexneri
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Protein G
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Essential for bacterial spreading by eliciting polar deposition of filamentous actin (actin-based motility). Inside the host cell mediates nucleation and polymerization of actin molecules on the bacterial surface, which provides the propulsive force for intracellular movement and intercellular dissemination of the bacterium. During invasion of mammalian cells, triggers autophagy by binding to APG5L. Interaction with IcsB leads to escape from the autophagic host defense system. Also binds ATP and displays weak ATPase activity.
基因功能參考文獻：
1. Identification of the H-NS and VirF-binding sites on the icsA promoter regions. PMID: 21724612
2. Data identified a putative autochaperone region required for IcsA biogenesis, and our data suggest an additional region, not previously identified, is required for N-WASP recruitment. PMID: 18456802
亞細胞定位：

[Outer membrane protein IcsA autotransporter]: Periplasm.; [Outer membrane protein IcsA]: Secreted. Cell surface. Note=The alpha domain is localized as a cap over the old pole of the bacterial surface.; [Outer membrane protein IcsA translocator]: Cell outer membrane; Multi-pass membrane protein. Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.
數據庫鏈接：

KEGG: sfl:CP0182

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