ICAM4 Antibody

說明書

中文名稱：

ICAM4兔多克隆抗體
貨號：

CSB-PA619892ESR1HU
規格：

￥440
圖片：
Western blot
All lanes: ICAM4 antibody at 4.98μg/ml + Mouse brain tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 30, 26 kDa
Observed band size: 30 kDa

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA619892ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA619892ESR1HU at dilution of 1:100
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ICAM4 Polyclonal antibody
Uniprot No.：

Q14773
基因名：

ICAM4
別名：

CD242 antibody; CD242 antigen antibody; ICAM-4 antibody; Icam4 antibody; ICAM4_HUMAN antibody; Intercellular adhesion molecule 4 antibody; Landsteiner Wiener blood group glycoprotein antibody; Landsteiner-Wiener blood group glycoprotein antibody; LW antibody; LW blood group protein antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Intercellular adhesion molecule 4 protein (20-140AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.
基因功能參考文獻：
1. the effect of modulation of the cAMP-PKA-dependent pathway on ICAM-4 receptor activation PMID: 28076805
2. Cytometry analysis evidenced a specific expression profile on reticulocytes of SCA infants, with notably an increased expression of the adhesion molecules Lu/BCAM, ICAM-4 and LFA-3, both in percentage of positive cells and in surface density. PMID: 26137540
3. Seven variant ICAM4 alleles were found, distinct from the wild-type ICAM4 allele (GenBank KF712272), known as LW*05 and encoding LW(a) . PMID: 24673173
4. Data from differentiating cultured erythroid precursor cells suggest that RhAG (Rh-associated glycoprotein) knockdown abolishes Rh blood group expression (ICAM4; RhoD [ras homolog family member D]; CD47 Rh-related antigen) in erythroid cells. PMID: 23417980
5. Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium. PMID: 22147898
6. In a transgenic mouse model of sickle cell disease ICAM-4 is implicated in abnormal adhesiveness of erythrocytes to endothelium. PMID: 20015873
7. LWa allele occurs with incidence of 100% of donors in this study, while LWb allele has not been found in Chinese population. PMID: 18549656
8. ICAM-4 as the first red blood cells protein ligand of platelets that may have relevant physiological significance PMID: 12477717
9. binds to the I domains of the CD11a/CD18 and CD11b/CD18 leukocyte integrins PMID: 12694184
10. 12 single amino-acid changes in ICAM4 affected the interaction of ICAM-4 with alpha(V) integrins PMID: 14551135
11. LW on sickle but not on normal erythrocytes undergoes increased PKA-dependent serine phosphorylation as a result of activation. The major counter receptor for LW was identified as the alphavbeta3 integrin on ECs PMID: 15308566
12. Different integrins bind to different but partly overlapping sites on ICAM4, and ICAM4 may accommodate multiple integrin receptors present on leukocytes, platelets and endothelial cells. PMID: 15355350
13. Review. LW antigen contributes to RBC adhesion, thrombosis, and (in sickle cell disease) vaso-occlusion. PMID: 16564726
14. We show that ICAM-4 functions as a ligand for the monocyte/macrophage-specific CD11c/CD18. Deletion of the individual immunoglobulin domains of ICAM-4 demonstrated that both its domains contain binding sites for CD11c/CD18. PMID: 16985175
15. LW play potentially pathophysiological roles in sickle cell disease PMID: 17609430
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亞細胞定位：

[Isoform Long]: Cell membrane; Single-pass type I membrane protein.; [Isoform Short]: Secreted.; Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Immunoglobulin superfamily, ICAM family
組織特異性：

Erythrocytes.
數據庫鏈接：

HGNC: 5347

OMIM: 111250

KEGG: hsa:3386

STRING: 9606.ENSP00000342114

UniGene: Hs.706750

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