HTR3A Antibody

說明書

中文名稱：

HTR3A兔多克隆抗體
貨號：

CSB-PA981968
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA981968(HTR3A Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P46098
基因名：

HTR3A
別名：

HTR3A; 5HT3R; HTR3; 5-hydroxytryptamine receptor 3A; 5-HT3-A; 5-HT3A; 5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R; Serotonin receptor 3A; Serotonin-gated ion channel receptor
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Fusion protein of Human HTR3A
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
基因功能參考文獻：
1. This study demonstrated that the C and E subunits when assembled as simple or complex heteromeric 5-HT3 receptors may alter efficacies of serotonin and clinically used antagonists. PMID: 29793334
2. Methylation status of the HTR3A gene in mothers is linked to maternal violence-related psychopathology, trauma-induced brain activation patterns, and child attachment disturbance during a sensitive period in the development of self-regulation. PMID: 27720744
3. This study did not found HTR3A play a major role in predicting Antipsychotic-Induced Weight Gain. PMID: 28531893
4. Methylation pattern changes in the 5-HTR3A gene were associated with suicidal behavior in borderline personality disorder, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD). PMID: 28470485
5. findings suggest that HTR3A mRNA expression levels were positively correlated with craving in Han Chinese alcohol-dependent patients. PMID: 27144979
6. Study provides structural data showing the orientation of palonosetron in a 5-HT3 receptor binding site mimic, combined with functional data in the 5-HT3 receptor, provide an explanation for the high affinity and long-lived actions of this compound. These are likely due to specific interactions formed with binding site residues, and its location as a tight and effective wedge in the binding pocket. PMID: 27656911
7. Studies have demonstrated that 5-HT3 receptors modulate the activity of vascular and non-vascular smooth muscles. PMID: 27720614
8. The HTR3A rs1062613 polymorphisms do not seem to directly influence experimental muscle pain in healthy individuals. However, women reported higher pain intensity and larger pain area than men, which might partly be attributed to genotype. PMID: 28002447
9. Studies with 16 arylguanidines found that their functional activity spanned a broad spectrum from superagonist to full agonist, partial agonist, and antagonist at 5-HT3 receptors; results confirm the utility of phenylguanidine as an extremely versatile scaffold in the design of 5-HT3 ligands with a "tunable" level of agonist or antagonist activity PMID: 27533595
10. Analysis of our small Chinese sample revealed a significant association of HTR3A with bipolar disorder, but yielded no evidence of an association between HTR3B and bipolar disorder. Furthermore, evidence for an association was found for a haplotype of HTR3A. PMID: 27706728
11. Serotonin 3A receptor (5-HT3AR) is associated at the genetic and epigenetic levels with a variety of psychiatric disorders. PMID: 26350166
12. A gene-environment interaction is revealed between childhood trauma and 5-htr3a polymorphisms. PMID: 26701104
13. 5-HT3A receptor distal targeting in axons and dendrites depends on P2X2R expression. PMID: 26843630
14. Agonist- and antagonist-induced up-regulation of surface 5-HT3 A receptors PMID: 25989383
15. Data indicate that no two n-alkanols act alike, their spectra of effects on serotonin receptor 3A (5-HT3A) receptors differ. PMID: 25863270
16. Our findings support the notion that different haplotypes of HTR3A have reciprocal effects in the etiology of Postoperative nausea. PMID: 25339231
17. HTR3A gene variants may contribute to variability in severity of and response to antiemetic therapy for nausea and vomiting of pregnancy. PMID: 23786674
18. These data support a role for intracellular salt bridges in maintaining the quaternary structure of the 5-HT3 receptor and suggest a role for the intracellular domain in allosteric modulation of cooperativity and agonist efficacy. PMID: 24283776
19. To conclude, considering 5-hydroxytryptamine 3A subtype receptor role in accomplishment of asthma symptoms, this increase in its expression may exacerbate the seriousness of asthma disease. PMID: 24338226
20. Data suggest that HTR3A/HTR3B subunits readily form functionally distinct heteromeric receptors; molecular models have been developed regarding affinities of competitive ligands, non-competitive antagonists, and allosteric modulators. [REVIEW] PMID: 23489111
21. A significant increase in the relative expression level of 5-HT(3A) receptor in PBMCs. PMID: 24304330
22. variants in HTR3A, HTR3B, and SLC6A4 interactively contribute to etiology of alcohol, cocaine, and nicotine dependence PMID: 24590108
23. the stoichiometry of 5-HT3AB receptors on the plasma membrane PMID: 23972841
24. HTR3A, HTR3B, and SLC6A4 have significant interactions among their genes and are highly involved in nicotine dependence. PMID: 23290502
25. Mutagenic analysis of the intracellular portals of the human 5-HT3A receptor. PMID: 24030822
26. Genetic variability within SLC6A4, HTR3A, and HTR3B contributes to the risk of alcohol dependence and related phenotypes. PMID: 23757001
27. Data indicate that Arg-436 is critical for the inward rectification of 5-HT3A receptor-mediated macroscopic currents. PMID: 23740249
28. Polymorphisms in the HTR3A gene are predictors of reduced alcohol drinking in response to ondansetron. PMID: 23897038
29. The findings of the present study do not support the involvement of the 5-HTR3A gene C178T polymorphism in tardive dyskinesia in Korean schizophrenia subjects. PMID: 23126479
30. The association between HTR3A gene SNP and response to clozapine is influenced by various clinical predictors and by differing outcome definitions in patients with treatment-resistant schizophrenia. PMID: 22700043
31. HTR3A and HTR3B were detected in all investigated brain tissues with the exception of the cerebellum, and large differences in the A:B subunit ratio were observed. PMID: 22832903
32. Thus, rather than involving the 5-HT3-dependent pathway, the negative effect of ondansetron on platelet aggregation is instead manifested through the attenuation of agonist-induced IP3 production and MAPK (p38 and ERK2). PMID: 22818390
33. This study does not support the hypothesis that the 5-HT(3A) receptor plays a major role in the pathogenesis of schizophrenia. PMID: 22328445
34. CC genotype of TPH2 rs2171363, GG genotype of TPH2 rs7305115, CC genotype of HTR2A rs2770304, and CC genotype of HTR2A rs6313 were associated with reduced internalizing scores for children born in the quartile above the birth weightmidpoint. PMID: 21969281
35. The serotonin receptor 3A c.-42T allele is associated with severe dyspeptic symptoms. The stronger association among dyspeptic patients carrying the serotonin transporter L allele suggests an additive effect of the two polymorphisms. PMID: 22014438
36. Data show that 5-HTA/bungarotoxin binding sequence (BBS) receptors are constitutively internalized in the absence of an agonist and internalization as well as receptor function are inhibited by fluorescence. PMID: 21338684
37. Report significant correlations of the HTR3A polymorphisms with amygdala responsiveness, anxiety, and irritable bowel syndrome symptom severity. PMID: 21420406
38. Rings of charge within the extracellular vestibule influence ion permeation of the 5-HT3A receptor. PMID: 21454663
39. findings indicate that HTR3A and HTR3B polymorphisms may not play a major role in the susceptibility to suicidal behavior in schizophrenia subjects. PMID: 21184810
40. These findings suggest that the HTR3A CC genotype may be associated with alterations in brain structures central to emotion processing, particularly when exposed to stress. PMID: 20694966
41. Six functional and coding variants of the subunit genes HTR3A, HTR3B as well as the novel HTR3C, HTR3D, and HTR3E subunits in the response to haloperidol or risperidone, were assessed. PMID: 19794330
42. RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits. PMID: 20522555
43. Evaluate HTR3A expression in normal and neoplastic B cells. PMID: 20516728
44. variants in the HTR3A receptor gene can play a role in the treatment outcome of clozapine in schizophrenia patients that are refractory or intolerant of typical antipsychotic therapy PMID: 20168265
45. 5-HT(3)A residue 312 and equivalent polar residues in the M3 of other Cys-loop subunits are essential determinants of homopentameric gating. PMID: 19933756
46. the present investigation on transfected HEK293 cells revealed that Arg344His mutation of the h5-HT3A receptor, although not involved in genetic predisposition to schizophrenia, leads to a decreased density of the variant compared to wild type receptor PMID: 19904001
47. These data provide direct evidence for an extracellular N-terminal domain and an intracellular loop between the third and fourth transmembrane domains, thus supporting the conventional ligand-gated ion channel subunit topological model. PMID: 12059035
48. species-dependent gating mechanisms of 5-HT(3) receptors PMID: 12457738
49. Cell surface expression of 5-hydroxytryptamine type 3 receptors is controlled by an endoplasmic reticulum retention signal PMID: 12750374
50. 5HT3A receptor function and trafficking is regulated by protein kinase c through an F-actin-dependent mechanism PMID: 12791692
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亞細胞定位：

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
蛋白家族：

Ligand-gated ion channel (TC 1.A.9) family, 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily, HTR3A sub-subfamily
組織特異性：

Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta.
數據庫鏈接：

HGNC: 5297

OMIM: 182139

KEGG: hsa:3359

UniGene: Hs.413899

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