HSD17B4 Antibody
-
中文名稱：HSD17B4兔多克隆抗體
-
貨號(hào)：CSB-PA287281
-
規(guī)格：￥1100
-
圖片：
-
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA287281(HSD17B4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA287281(HSD17B4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200) -
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Huvec cells, K562 cells, Primary antibody: CSB-PA287281(HSD17B4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
-
-
其他：
產(chǎn)品詳情
-
Uniprot No.：
-
基因名：HSD17B4
-
別名：12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase antibody; 17 beta HSD 4 antibody; 17 beta HSD IV antibody; 17 beta hydroxysteroid dehydrogenase 4 antibody; 17-beta-HSD 4 antibody; 17-beta-hydroxysteroid dehydrogenase 4 antibody; 17beta estradiol dehydrogenase type IV antibody; 3 alpha 7 alpha12 alpha trihydroxy 5 beta cholest 24 enoyl CoA hydratase antibody; 3-alpha antibody; 7-alpha antibody; Beta hydroxyacyl dehydrogenase antibody; Beta keto reductase antibody; D 3 hydroxyacyl CoA dehydratase antibody; D bifunctional protein antibody; D bifunctional protein peroxisomal antibody; D-3-hydroxyacyl CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein antibody; D-bifunctional protein antibody; D-bifunctional protein, peroxisomal antibody; DBP antibody; DBP, peroxisomal antibody; DHB4_HUMAN antibody; EDH17B4 antibody; Enoyl-CoA hydratase 2 antibody; Hsd17b4 antibody; Hydroxysteroid (17-beta) Dehydrogenase 4 antibody; MFE 2 antibody; MFE-2 antibody; MPF-2 antibody; Multifunctional protein 2 antibody; Peroxisomal multifunctional enzyme type 2 antibody; Peroxisomal multifunctional protein 2 antibody; PRLTS1 antibody; SDR8C1 antibody; Short chain dehydrogenase/reductase family 8C member 1 antibody
-
宿主：Rabbit
-
反應(yīng)種屬：Human,Mouse,Rat
-
免疫原：Fusion protein of Human HSD17B4
-
免疫原種屬：Homo sapiens (Human)
-
標(biāo)記方式：Non-conjugated
-
抗體亞型：IgG
-
純化方式：Antigen affinity purification
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
-
產(chǎn)品提供形式：Liquid
-
應(yīng)用范圍：ELISA,WB,IHC
-
推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 IHC 1:50-1:200 -
Protocols：
-
儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
功能：Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from straight-chain, 2-methyl-branched-chain fatty acids bile acid intermediates. With EHHADH, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity.
-
基因功能參考文獻(xiàn)：
- This study reveals a crosstalk between acetylation and chaperone-mediated autophagy degradation in HSD17B4 regulation. PMID: 28296597
- we identified that methylation of the promoter CpG island of HSD17B4 was associated with the pathological complete response of HER2-positive breast cancer to trastuzumab and chemotherapy with a specificity of 79% PMID: 28186977
- Our findings supported that HSD17B4 was one of the genes contributing to Perrault syndrome in this consanguineous Chinese Han family. PMID: 28830375
- ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4, LARS2, CLPP and C10orf2 PMID: 26970254
- Results show that HSD17B4 is highly expressed in hepatocellular carcinoma (HCC) cells and activated NF-kappaB co-localized with the NF-kappaB-responsive element of HSD17B4 suggesting that HSD17B4 plays an important role in aggravated HCC progression. PMID: 25448063
- Structural MFE-2 instability is the molecular basis of D-bifunctional protein deficiency type III. PMID: 23308274
- Specific combination of compound heterozygous mutations in 17beta-hydroxysteroid dehydrogenase type 4 (HSD17B4) defines a new subtype of D-bifunctional protein deficiency. PMID: 23181892
- Molecular models of domain structure of MFE-2 from human, C. elegans, and Drosophila melanogaster lend support to possible structural role of MFE-2 domains including SCP-2L (sterol carrier protein 2-like) domain in human and C. elegans proteins. PMID: 23313254
- Epistasis between the HSD17B4 and thyroglobulin polymorphisms is associated with premature ovarian failure. A haplotype in the HSD17B4 gene was identified that was significantly associated with resistance to POF PMID: 22265031
- The diagnosis of a type III DBPD with a missense mutation (T15A) in the HSD17B4 gene, coding for D-bifunctional protein (DBP), could be established. PMID: 20949532
- MFE2 anchors its substrate around the region from Trp(249) to Arg(251) and positions the substrate along the hydrophobic cavity in the proper direction toward the catalytic center PMID: 20566640
- Perrault syndrome and DBP deficiency overlap clinically and Perrault syndrome is genetically heterogeneous. PMID: 20673864
- rs11205 in HSD17B4 was associated with testicular germ cell tumor. Risk doubled per copy of the minor A allele. Homozygosity of this allele quadrupled the risk vs. homozygous major G allele. The risk was increased both for seminoma & nonseminoma. PMID: 19776291
- crystal structure of 2-enoyl-CoA hydratase 2 PMID: 15644212
- Deficiency of this enzyme in man causes a severe developmental syndrome with abnormalities in several organs but in particular in the brain, leading to death within the first year of life. PMID: 16766224
- HSD17B4 is not only associated with the presence of prostate cancer, but is also a significant independent predictor of poor patient outcome. PMID: 19100308
- HSD17B4 mRNA is expressed in human skin, at similar levels in men and women. HSD17B4 levels are not altered by topical 17-beta-estradiol treatment. PMID: 18794456
顯示更多
收起更多
-
相關(guān)疾病：D-bifunctional protein deficiency (DBPD); Perrault syndrome 1 (PRLTS1)
-
亞細(xì)胞定位：Peroxisome.
-
蛋白家族：Short-chain dehydrogenases/reductases (SDR) family
-
組織特異性：Present in many tissues with highest concentrations in liver, heart, prostate and testis.
-
數(shù)據(jù)庫(kù)鏈接：
Most popular with customers
-
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
-
