HOXA5 Antibody
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中文名稱：HOXA5兔多克隆抗體
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貨號：CSB-PA184271
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規格：￥2024
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圖片：
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Western blot analysis of extracts from Jurkat cells, using HXA5 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) HOXA5 Polyclonal antibody
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Uniprot No.：
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基因名：HOXA5
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from N-terminal of Human HXA5.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.
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基因功能參考文獻：
- HOXA5 functions as a tumor suppressor in regulating tumor growth of gastric cancer (GC) under regulation of miR-196a, supporting its potential utility as a therapeutic target for GC. PMID: 30267809
- LncRNA GAS5 depressed OA development by targeting miR-196a-5p and thereby down-regulating HOXA5 expression, providing substance for developing lncRNA-based strategies to treat OA. PMID: 30201235
- Low HOXA5 expression is associated with Gastric cancer. PMID: 30015922
- Research demonstrated that depletion of HOXA5 inhibited osteogenic differentiation and repressed cell proliferation by arresting cell cycle progression at the S phase via p16(INK4A) , p18(INK4C) , and Cyclin A in SCAPs, indicating that HOXA5 has a significant role in maintaining the proliferation and differentiation potential of dental-tissue-derived MSCs. PMID: 28833816
- The study demonstrated that MPP8 was associated with non-small cell lung cancer cell proliferation through regulation of HOXA5. PMID: 29412790
- The present study demonstrates that HOXA5 can be silenced in the psoriatic stratum corneum due to DNA methylation of the CGI located in the 5' region of HOXA5. PMID: 28482119
- study implicates HOXA5 as a chromosome 7-associated gene-level locus that promotes selection for gain of whole chromosome 7 and an aggressive phenotype in glioblastoma. PMID: 29632085
- HOXA5 could bind in the promoter of linc00312 and up-regulated the expression of it. PMID: 28338293
- HOXA5 was identified as a tumor suppressor gene, which inhibited non-small-cell lung cancer metastasis by regulating cytoskeletal remodeling. Its expression is repressed by linc00673 through binding with EZH2. PMID: 28423732
- lung cancer stem-like cells have plasticity under a condition of oxidative stress, and HOAX5 has a critical role in dedifferentiation PMID: 27418136
- loss of HOXA5 in mammary cells leads to loss of epithelial traits, an increase in stemness and cell plasticity, and the acquisition of more aggressive phenotypes. PMID: 27157614
- ATRA may inhibit the proliferation of K562 cells and promote apoptosis by upregulating the HOXA5 mRNA and protein expression. PMID: 27052693
- Knockdown of HOXA5 suppressed the proliferation and metastasis of esophageal squamous cell cancer cells. PMID: 27960137
- high expression levels of HOXA5 mRNA and protein in children with ALL indicate that HOXA5 is closely associated with childhood ALL. PMID: 26846409
- Downregulation of HOXA5 by shRNA may trigger apoptosis and overcome drug resistance in leukemia cells. PMID: 26397212
- HOXA5-induced apoptosis was p53-independent. PMID: 26219418
- Among the mechanosensitive genes, the two transcription factors, HoxA5 and Klf3, contain cAMP-response-elements methylation of which could serve as a mechanosensitive master switch in gene expression in atherosclerosis. (Review) PMID: 25979369
- In colon cancer, HOXA5 is downregulated, and its re-expression induces loss of the cancer stem cell phenotype, preventing tumor progression and metastasis. PMID: 26678341
- Ectopic expression of HOXA5 in highly invasive cancer cells suppressed cell migration, invasion, and filopodia formation in vitro and inhibited metastatic potential in vivo. PMID: 25875824
- Increased expression of HOXA5 is associated with acute myeloid leukemia. PMID: 25987065
- Our findings present that decreased HOXA5 could be identified as a poor prognostic biomarker in nonsmall cell lung cancer and regulate cell proliferation and invasion PMID: 25549794
- miR-1271 regulates non-small-cell lung cancer cell proliferation and invasion, via the down-regulation of HOXA5. PMID: 25686496
- Our analysis showed that miR-196a suppressed the expression of HOXA5 both at the mRNA and protein levels; knockdown of HOXA5 expression in A549 cells using RNAi was shown to promote NSCLC cell proliferation, migration and invasion. PMID: 22876840
- HOXA5 can suppress keratinocytes growth and epidermal formation. PMID: 22464764
- since lower levels of HOXA5 predict poor prognosis, this gene may be a novel candidate for development of therapeutic strategies in OSCC. PMID: 22227861
- Androgen receptor mutations are associated with altered epigenomic programming as evidenced by HOXA5 methylation. PMID: 21311178
- The methylation percentage of HOXA5 in AML patients was higher than that of HOXA5 in control patients. PMID: 20890077
- HOXA5 is hypermethylated in clear cell renal cell carcinoma. PMID: 20846263
- engineered a p53-mutant breast cancer cell line, Hs578T, to inducibly express HOXA5. Expression of HOXA5 can induce apoptosis through an apoptotic mechanism mediated by caspases 2 and 8. PMID: 14701762
- loss of HOXA5 expression could lead to the functional activation of Twist resulting in aberrant cell cycle regulation and promoting breast carcinogenesis PMID: 15545268
- analysis of transcriptional targets of HOXA5 by microarray hybridization PMID: 15757903
- Hox A5 expression is inconsistent with an angiogenic phenotype; expression of Hox A5 may help to maintain existing vessels in a quiescent, differentiated state. PMID: 16379594
- HOXA5 is a transcriptional regulator of hMLH1 in breast cancer cells PMID: 16756717
- HOXA5 expression was maintained at stable levels at different reproductive stages of a woman's life, except during lactation. HOXA5 protein expression levels in breast carcinomas inversely co-relates with Epidermal Growth Factor Receptor expression. PMID: 17167183
- Study identified hypermethylation and gene inactivation of HOXA4 and HOXA5 was frequently observed (26-79%) in all types of leukemias studied. PMID: 17785556
- HOXA5 acts directly downstream of RARbeta and may contribute to retinoid-induced anticancer and chemopreventive effects. PMID: 17804711
- miR-130a is a regulator of the angiogenic phenotype of vascular endothelial cells largely through its ability to modulate the expression of GAX and HOXA5 PMID: 17957028
- The promoter methylation status of a panel of critical growth regulatory genes, RASSF1A, RARbeta2, BRCA1 and HOXA5, in 54 breast cancers and 5 distant normal breast tissues of Indian patients, was analyzed. PMID: 18538349
- Epigenetic inactivation of Homeobox A5 gene is associated with nonsmall cell lung cancer. PMID: 19554572
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亞細胞定位：Nucleus.
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蛋白家族：Antp homeobox family
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