HMOX2 Antibody

說明書

中文名稱：

HMOX2兔多克隆抗體
貨號：

CSB-PA204326
規格：

￥1100
圖片：
Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: HepG2 cells, Primary antibody: CSB-PA204326(HMOX2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P30519
基因名：

HMOX2
別名：

Heme oxygenase (decycling) 2 antibody; Heme oxygenase (decyclizing) 2 antibody; Heme oxygenase 2 antibody; HMOX 2 antibody; Hmox2 antibody; HMOX2 protein antibody; HMOX2_HUMAN antibody; HO 2 antibody; HO-2 antibody; HO2 antibody; OTTHUMP00000159847 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Fusion protein of Human HMOX2
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:5000
WB	1:500-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
基因功能參考文獻：
1. The frequencies of genotype and allelic variants of ALAD rs1800435 did not differ significantly between patients with essential tremor (ET) and controls, and were not influenced by gender. Subjects carrying the ALAD rs1800435CC genotype (wild-type) and the HMOX2 rs1051308GG genotype or the HMOX2 rs1051308G allele had significantly decreased risk for ET. PMID: 28276576
2. HO-2 is a cellular myristate-binding protein that negatively regulates both virus replication and host inflammatory responses. PMID: 28132836
3. Our results suggest that rs1051308 is associated with risk of developing Parkinson disease in Han Chinese, and further studies involving various ethnicities are needed to validate the association. PMID: 28179208
4. High HMOX2 expression is associated with bladder cancer. PMID: 28320388
5. HMOX2 contributes to high-altitude adaptation in Tibetans by functioning as a modifier in the regulation of hemoglobin metabolism. PMID: 26781569
6. a weak association between HMOX2 rs1051308 polymorphisms and the risk to develop essential tremor in the Spanish population. PMID: 26091465
7. Taken together with EPR measurements, which show the appearance of a new low-spin heme signal in reduced HO2, it appears that a cysteine residue(s) in the HRMs directly interacts with a second bound heme PMID: 25849895
8. HO-2 protein is expressed in the cytosols of skin cancer cells. PMID: 25864768
9. Interactions of HO-2 with CPR and BVR, were evaluated. PMID: 25196843
10. increased expression of nucleated RBC, HSP90alpha and corresponding decreased expression of HO-2 in such hypoxic condition may play a protective role; to prevent cord blood RBC against stress induced damage during preeclampsia. PMID: 22935040
11. PFKFB4 and HO-2 are expressed in a coordinated manner to maintain glucose homeostasis. PMID: 22892400
12. Role of cysteine residues in heme binding to human heme oxygenase-2 elucidated by two-dimensional NMR spectroscopy. PMID: 22923613
13. Although the carboxy-terminal deletion mutant of HO-2 is found in the nucleus, translocation of HO-2 to the nucleus does not occur under conditions of hypoxia. PMID: 22545110
14. for the first time, copy number variations in the HMOX2 gene and an association of the SNP rs2270363 with Parkinson's disease risk. PMID: 21709601
15. Results suggest that the c.544G>A polymorphism of the heme oxygenase-2 gene is not associated with age-related macular degeneration in this population. PMID: 21804464
16. HO-2, which is highly expressed in the corneal epithelium, appears to be critical for the wound healing process in the cornea. PMID: 21506105
17. These findings are consistent with the presence of a hydrogen-bonding network at the heme's distal side within the active site of HO-2 with potentially significant differences from that observed in HO-1. PMID: 20502928
18. There was positive correlation between seminal plasma HO enzyme activity and sperm concentration, per cent of motile spermatozoa, number of motile spermatozoas ml(-1) and significant negative correlation with per cent of sperm abnormal forms. PMID: 20629646
19. high expression in keratinocytes prevents basal and radiation-induced gene expression of heme oxygenase 1 PMID: 19874887
20. HO-2 is important in maintaining endothelial viability and may preserve local regulation of vascular tone, thrombosis, and inflammatory responses during reductions in systemic oxygen delivery PMID: 20118244
21. HO-2 protein content was decreased by 17% and 5% in human trophoblast cells after 24-h exposure to 1% and 5% O(2), respectively, versus 20% O(2) but unchanged in chorionic villi PMID: 12578814
22. Low expression of HO-2 may lead to enhanced levels of free heme at the feto-maternal interface, with subsequent upregulation of adhesion molecules, allowing enhanced inflammatory cells migration to the feto-maternal interface. PMID: 14506930
23. HO-2 is part of the BK channel complex and enhances channel activity in normoxia PMID: 15528406
24. Catalytically inactive mutant, HO-2H45A, overexpressed in HEK293 cell lines was more sensitive to hemin as compared to control. HO-2H45A was also able to protect cells against oxidative stress injury. PMID: 16043027
25. Review summarizes function of hemoxygenase-2 as an oxygen sensor of native and recombinant large conductance, voltage- and calcium-dependent potassium BK(Ca) channels expressed in carotid body glomus cells. PMID: 16137652
26. These results suggest that HO-2 may down-regulate the expression of HO-1, thereby directing the co-ordinated expression of HO-1 and HO-2. PMID: 17064313
27. Suggest membrane potential gradient in small intestine is dependent on carbon monoxide generated by HO-2 in interstital cells of Cajal. PMID: 17510199
28. the heme regulatory motifs in HO-2 constitute a thiol/disulfide redox switch that regulates the myriad physiological functions of HO-2, including its involvement in the hypoxic response in the carotid body PMID: 17540772
29. analysis of apo- and heme-bound crystal structures of a truncated human heme oxygenase-2 PMID: 17965015
30. HO-2 may be important in controlling trophoblast invasion. PMID: 19345412
31. The thiol/disulfide switch in HO-2 responds to cellular oxidative stress and reductive conditions, representing a paradigm for how heme regulatory motifs can integrate heme homeostasis with carbon monoxide signaling and redox regulation. PMID: 19473966
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亞細胞定位：

Microsome. Endoplasmic reticulum.
蛋白家族：

Heme oxygenase family
數據庫鏈接：

HGNC: 5014

OMIM: 141251

KEGG: hsa:3163

STRING: 9606.ENSP00000219700

UniGene: Hs.284279

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