HLA-F Antibody, HRP conjugated
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中文名稱：HLA-F兔多克隆抗體, HRP偶聯(lián)
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貨號：CSB-PA335552LB01HU
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規(guī)格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) HLA-F Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：CDA12 antibody; HLA 5.4 antibody; HLA class I histocompatibility antigen; alpha chain F antibody; HLA class I molecule antibody; HLA F antigen antibody; HLA-CDA12 antibody; HLA-F antibody; HLAF antibody; HLAF_HUMAN antibody; Leukocyte antigen F antibody; MHC class I antigen F antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human HLA class I histocompatibility antigen, alpha chain F protein (194-303AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation. Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC). In complex with B2M, presents non-canonical self-peptides carrying post-translational modifications, particularly phosphorylated self-peptides. Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance. Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors. Upon interaction with activating KIR3DS1 receptor on NK cells, triggers NK cell degranulation and anti-viral cytokine production. Through interaction with KIR3DL2 receptor, inhibits NK and T cell effector functions. May interact with other MHC class I OCs to cross-present exogenous viral, tumor or minor histompatibility antigens to cytotoxic CD8+ T cells, triggering effector and memory responses. May play a role in inflammatory responses in the peripheral nervous system. Through interaction with KIR3DL2, may protect motor neurons from astrocyte-induced toxicity.
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基因功能參考文獻：
- interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. PMID: 30031767
- the results of this study provide a blueprint of the molecular details of HLA-F, which will inform future exploration of its roles in human health and allow for the development of additional, targeted therapeutics PMID: 28636952
- this study established HLA-F as a ligand of KIR3DS1 and have demonstrated cell-context-dependent expression of HLA-F that might explain the widespread influence of KIR3DS1 in human disease, including delayed progression of disease caused by human immunodeficiency virus type 1 PMID: 27455421
- Two eSNPs were associated with fecundability at a FDR of 5%; both were in the HLA region and were eQTLs for the TAP2 gene (P = 1.3x10-4) and the HLA-F gene (P = 4.0x10-4), respectively. PMID: 27447835
- provides substantial evidence that the rs7903146 variant is significantly associated with the risk of diabetic retinopathy in Caucasian populations PMID: 26332651
- Overexpression of a single MHCI molecule, HLA-F, protects human MNs from ALS astrocyte-mediated toxicity, whereas knockdown of its receptor, the killer cell immunoglobulin-like receptor KIR3DL2, on human astrocytes results in enhanced motor neurons death PMID: 26928464
- This is the first study regarding HLA-F polymorphisms in a Euro-Brazilian population contributing to the Southern Brazilian genetic characterization. PMID: 25413105
- The effect of Japanese encephalitis virus and TNF-alpha exposure on NFkappaB-mediated induction of HLA-F is reported. PMID: 25461528
- A previously unrecognized model of Ag cross-presentation mediated by HLA-F & MHC-I open conformers on activated lymphocytes & monocytes may significantly contribute to the regulation of immune system functions & the immune defense. PMID: 23851683
- expression in gastric cancer lesion was unrelated to patient prognosis PMID: 23542057
- HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors. PMID: 24018270
- Upregulated HLA-F expression (p = 0.026) and downregulated HLA I expression (p = 0.013) could be an independent unfavorable prognostic factor. PMID: 22544725
- surface marker on activated lymphocytes PMID: 20865824
- These data suggest that HLA-F is expressed independently of peptide and that a physical interaction specific to MHC-I HC plays a role in the function of MHC-I HC expression in activated lymphocytes. PMID: 20483783
- This is the first example of placental HLA-F expression--primarily in trophoblasts that have invaded the maternal decidua--in the same cells that simultaneously express the other two nonclassical class I antigens HLA-E and HLA-G. PMID: 12874228
- HLA-F surface expression on B cell and monocyte cell lines correlates with the presence of a limited amount of endoglycosidase H (Endo H)-resistant HLA-F; however, clearly not all surface-expressed HLA-F is fully glycosylated. PMID: 14607927
- HLA-F is entirely dependent on its cytoplasmic tail for export from the endoplasmic reticulum. PMID: 16709803
- the role of NKG2D and 2B4 is not focussed on trophoblast recognition in normal pregnancy, but is more likely involved in cross-talk among maternal cells of the placental bed PMID: 18658158
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亞細胞定位：Cell membrane; Single-pass type I membrane protein. Early endosome membrane. Lysosome membrane.
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蛋白家族：MHC class I family
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組織特異性：Expressed in resting B cells (at protein level). Expressed in secondary lymphoid organs rich in B and T cells such as the tonsils, spleen, and thymus (at protein level). Expressed in the endothelial cells of the tonsils. Expressed on activated lymphoid ce
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