HINFP Antibody, Biotin conjugated

說明書

中文名稱：

HINFP兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA010361LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) HINFP Polyclonal antibody
Uniprot No.：

Q9BQA5
基因名：

HINFP
別名：

DKFZp434F162 antibody; HiNF-P antibody; HINFP antibody; HINFP_HUMAN antibody; Histone H4 gene specific protein HiNF P antibody; Histone H4 transcription factor antibody; Histone nuclear factor P antibody; MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein antibody; MBD2 interacting zinc finger 1 antibody; MBD2 interacting zinc finger protein antibody; MBD2-interacting zinc finger protein antibody; Methyl CpG binding protein 2 interacting zinc finger protein antibody; Methyl-CpG-binding protein 2-interacting zinc finger protein antibody; MIZF antibody; ZNF743 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Histone H4 transcription factor protein (370-515AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.
基因功能參考文獻：
1. purified and functionally characterized the critical transcription factor HiNF-P, which is required for E2F-independent activation of the histone H4 multigene family PMID: 14585971
2. These results suggest that transcriptional repression of Rb by MIZF could be one of the critical determinants in myogenic differentiation. PMID: 15541338
3. HiNF-P interacts directly with p220(NPAT) to coactivate histone genes during S phase. PMID: 15988025
4. the transcriptional silencing of the 14-3-3sigma gene is caused by promoter CpG island methylation associated with MBD2, which may play an important role in prostate cancer progression during the invasive and metastatic stages of the disease PMID: 16786000
5. These results suggest that RFP is a mediator connecting several MBD proteins and allowing the formation of a more potent transcriptional repressor complex. PMID: 17049487
6. HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription. PMID: 17163457
7. HiNF-P-dependent stabilization of p220NPAT reinforces signaling through the cyclin E/CDK2/p220NPAT pathway and contributes to coordinate control of histone gene expression. PMID: 17176114
8. HiNF-P/P220NPAT regulates expression of nonhistone targets that influence competency for cell cycle progression. PMID: 17974976
9. a novel HiNF-P-specific conserved region represents a DNA-binding determinant that plays a role in mediating histone gene expression during the cell cycle and defines HiNF-P as a cell cycle regulatory member of the zinc finger transcription factor family PMID: 18850719
10. Results suggest that cyclin-dependent kinase inhibitors selectively control stimulation of the histone H4 gene promoter by the p220(NPAT)/HiNF-P complex. PMID: 19170105
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亞細胞定位：

Nucleus. Note=Associated with discrete nuclear foci.
組織特異性：

Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver.
數據庫鏈接：

HGNC: 17850

OMIM: 607099

KEGG: hsa:25988

STRING: 9606.ENSP00000318085

UniGene: Hs.504091

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