HDC Antibody
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中文名稱：HDC兔多克隆抗體
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貨號：CSB-PA005169
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規格：￥1090
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圖片：
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Western Blot analysis of K562 cells using HDC Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：HDC
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別名：DCHS_HUMAN antibody; EC 4.1.1.22 antibody; HDC antibody; Histidine decarboxylase antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human HDC.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the biosynthesis of histamine from histidine.
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基因功能參考文獻：
- Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. This review summarizes the analogies and differences in their origin as well as their common pathophysiological scenarios. [review] PMID: 27769832
- a Possible Role for the Histidine Decarboxylase Gene in Tourette Syndrome in the Chinese Han Population PMID: 27529419
- Human enterochromaffin-like cells appear to partially co-express VMAT-2 and HDC. Co-expression of VMAT-2 and HDC might be required for increased histamine production in patients with gastric neuroendocrine tumors. PMID: 26715806
- The findings indicate that polymorphisms of HDC gene were significantly associated with breast cancer in Chinese Han population and may be novel diagnostic or therapeutic targets for breast cancer. PMID: 24835231
- HDC rs17740607 polymorphism is at least a partial loss-of-function variant and acts as a protective factor against chronic heart failure PMID: 25846768
- Investigated variation across the HDC (histidine decarboxylase) gene for association with Tourette Syndrome. PMID: 23825391
- HDC production in the stomach is associated with bile acid exposure and its related transcriptional regulation network of FXR, SHP, and CDX1. PMID: 24415870
- Data indicate that histidine decarboxylase (HDC) is expressed by neutrophils. PMID: 23572231
- Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase. PMID: 22767596
- crystal of histidine decarboxylase belonged to space group C2, with unit-cell parameters a = 215.16, b = 112.72, c = 171.39 A, beta = 110.3 degrees PMID: 22684068
- It was shown that for serum and urine, HDC levels achieved sensitivities and specificities compatible to or even greater than those of established biomarkers for the diagnosis of intestinal mucosal injury in patients with acute intestinal obstruction. PMID: 21915437
- The novel concept that an autocrine loop, consisting of enhanced histamine synthesis by histidine decarboxylase, sustains cholangiocarcinoma growth is proposed. PMID: 21873469
- Variants in the HDC gene may play little or no role in Tourette Syndrome susceptibility in Chinese Han population. PMID: 22095709
- Studies provide lead compounds for inhibitors of ornithine decarboxylase and human histidine decarboxylase. PMID: 21454364
- The histidine decarboxylase allele Glu644 in homozygosity increases the risk of developing rhinitis in the studied population PMID: 20608921
- identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis which points to its role in Tourette's syndrome and tics PMID: 20445167
- the elevation of HDC expression during human monocytic differentiation PMID: 11556524
- HDC expression is regulated by gastrin through a complex cis-acting element, which binds at least three distinct nuclear factors PMID: 12372397
- Histidine decarboxylase promoter activity can be repressed by kruppel-like factor 4 PMID: 14670968
- histidine decarboxylase mRNA is found in human vascular smooth muscle and endothelial cells PMID: 15167966
- HDC and histamine content were significantly higher in the tumor specimens PMID: 15928846
- Chronic urticaria expresses high levels of HDC as compared to normal foreskin, breast skin and cultured human keratinocytes. PMID: 16297195
- HDC expression and histamine production are increased in the superficial kidney cortex zone during pregnancy PMID: 16760908
- Defective levels found in normal placenta compared with pre-eclampsia labor. PMID: 16822545
- Synthesis of histamine was found to be restricted to the basophil compartment of the CML clone and to depend on signaling through the PI3-kinase pathway. CML cells also expressed histamine receptors PMID: 16849647
- HDC SNP's are significantly associated with age at natural menopause in Caucasian women. PMID: 16919600
- Histamine decarboxylase expressed in endothelial cells of microvessels might play a role in regulating angiogenesis in esophageal squamous cell carcinomas. PMID: 19133005
- HFR was regulated by HIF-1 activation. Depletion of HIF-1alpha prevents hypoxic induction of HDC in BMMCs. Hypoxia induces HDC expression by transcriptional mechanisms dependent upon HIF-1. PMID: 19266161
- the apparent occurrence of an unusual TG 3' splice site in intron 4 is discussed PMID: 17672918
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蛋白家族：Group II decarboxylase family
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