GTF2H5 Antibody

中文名稱：

GTF2H5兔多克隆抗體
貨號：

CSB-PA010014EA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA010014EA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA010014EA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA010014EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) GTF2H5 Polyclonal antibody
Uniprot No.：

Q6ZYL4
基因名：

GTF2H5
別名：

GTF2H5 antibody; C6orf175 antibody; TTDA antibody; General transcription factor IIH subunit 5 antibody; General transcription factor IIH polypeptide 5 antibody; TFB5 ortholog antibody; TFIIH basal transcription factor complex TTD-A subunit antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human General transcription factor IIH subunit 5 protein (1-71AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，GTF2H5 Antibody (CSB-PA010014EA01HU)，的標記方式是Non-conjugated。對于GTF2H5 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應用
HRP	CSB-PA010014EB01HU	GTF2H5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA010014EC01HU	GTF2H5 Antibody, FITC conjugated
Biotin	CSB-PA010014ED01HU	GTF2H5 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.
基因功能參考文獻：
1. Low levels of GTF2H5 are associated with enhanced prognosis in high-grade serous ovarian cancer patients and may contribute to cisplatin sensitization. PMID: 26463438
2. Transcriptional differences found between various TFIIH subunit variants participate in the phenotypic variability observed among xeroderma pigmentosum, XP associated with Cockayne syndrome, and trichothiodystrophy individuals. PMID: 25620205
3. Findings give new insights into the behavior of TTDA within the context of a living cell and thereby shed light on the complex phenotype of TTD-A patients. PMID: 23729738
4. Observational study of gene-disease association. (HuGE Navigator) PMID: 20522537
5. p8/TTD-A, the tenth subunit of TFIIH, has a critical role in DNA repair where it triggers DNA opening by stimulating XPB ATPase activity together with the damage recognition factor XPC-hHR23B. PMID: 16427011
6. TTDA is the first Transcription Factor IIH subunit with a primarily nucleotide excision repair-dedicated role in vivo. PMID: 16669699
7. The solution structure of the p8/TTD-A protein, a small alpha/beta protein built around an antiparallel beta-sheet that forms a homodimer with an extended interface, is reported. PMID: 17350038
8. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 18270339
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相關疾病：

Trichothiodystrophy 3, photosensitive (TTD3)
亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

TFB5 family
數(shù)據(jù)庫鏈接：

HGNC: 21157

OMIM: 608780

KEGG: hsa:404672

STRING: 9606.ENSP00000415032

UniGene: Hs.356224

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