GSS Antibody

中文名稱：

GSS兔多克隆抗體
貨號：

CSB-PA009969LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: K562 whole cell lysate, Rat kidney tissue, Mouse liver tissue, Mouse kidney tissue
All lanes: GSS antibody at 5.1µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 53, 41 kDa
Observed band size: 53 kDa

IHC image of CSB-PA009969LA01HU diluted at 1:500 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA009969LA01HU diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GSS Polyclonal antibody
Uniprot No.：

P48637
基因名：

GSS
別名：

epididymis secretory sperm binding protein Li 64p antibody; epididymis secretory sperm binding protein Li 88n antibody; Glutathione synthase antibody; Glutathione synthetase antibody; GSH S antibody; GSH synthetase antibody; GSH-S antibody; GSHB_HUMAN antibody; GSHS antibody; GSS antibody; HEL-S-64p antibody; HEL-S-88n antibody; MGC14098 antibody; OTTHUMP00000030711 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human Glutathione synthetase protein (290-418AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，GSS Antibody (CSB-PA009969LA01HU)，的標記方式是Non-conjugated。對于GSS Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA009969LB01HU	GSS Antibody, HRP conjugated	ELISA
FITC	CSB-PA009969LC01HU	GSS Antibody, FITC conjugated
Biotin	CSB-PA009969LD01HU	GSS Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes.
基因功能參考文獻：
1. Data suggest that the potential of clusterin and glutathione synthetase (GSH-S) as platelet biomarkers for early detection of colorectal cancer (CRC) could improve existing screening modalities in clinical application. PMID: 28849249
2. Mutation in Glutathione Synthase gene is associated with chronic metabolic acidosis in glutathione synthetase deficiency. PMID: 26669244
3. Four SNPs (rs7265992, rs6060124, rs7260770, and rs4911455) in GSS were significantly associated with bladder cancer recurrence after transurethral resection and BCG treatment. PMID: 25851338
4. In this study, clinical, biochemical, and genetic aspects of five Chinese 5-oxoprolinuria patients with OPLAH or GSS gene mutations were investigated. PMID: 25851806
5. Studied the role of protein-protein interactions in the structural stability, activity and allostery of enzymes using the obligate homodimer human glutathione synthetase as an ideal model. PMID: 25070563
6. The findings indicate that Asp458 is essential for hGS catalysis and that it impacts the allostery of hGS. PMID: 21771585
7. These results imply that residues V44 and V45 are integral to the stability of human glutathione synthetase. PMID: 21683691
8. We have shown that susceptibility to health effects of air pollution on lung function growth is associated with genetic variation in the GSS gene PMID: 20802163
9. Single-nucleotide polymorphism in glutathione synthetase is associated with small-cell lung cancer. PMID: 20439344
10. This research indicates that Gly369 and Gly370 have essential roles in hGS, while Gly371 has a lesser involvement. PMID: 20800579
11. the cause of cellular ATP depletion in nephrotic cystinosis may be the futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase PMID: 20413906
12. A novel alternative splicing variant (ASV) of the GSS gene was identified in 10 human normal tissues and five human cancer cell lines. PMID: 19672693
13. Glutathione synthetase deficiency: is gamma-glutamylcysteine accumulation a way to cope with oxidative stress in cells with insufficient levels of glutathione? PMID: 12638941
14. analysis of conserved residues of human glutathione synthetase PMID: 14990577
15. The cloning and characterization of a 2.2 kb 5'-flanking region of the human glutathione synthetase gene is reported. PMID: 15890065
16. glutathione synthetase autosomal mutations result in glutathione synthetase deficiency, which may cause progressive retinal dystrophy with hyperpigmentations and maculopathy [case report] PMID: 17206463
17. Glutathione synthase expression may indicate better survival in early stage adenocarcinoma of the lung, and manipulation of glutathione synthase may be a potential basis for treatment of some non-small cell lung cancers. PMID: 17234469
18. Severe glutathione synthetase deficiency is associated with progressive retinal dystrophy of the rod-cone type, affecting the central retina with advanced macular edema in adulthood. PMID: 19111905
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相關疾病：

Glutathione synthetase deficiency (GSS deficiency); Glutathione synthetase deficiency of erythrocytes (GLUSYNDE)
蛋白家族：

Eukaryotic GSH synthase family
數據庫鏈接：

HGNC: 4624

OMIM: 231900

KEGG: hsa:2937

STRING: 9606.ENSP00000216951

UniGene: Hs.82327

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